Published in Science on June 13, 2003
The biodiversity of the Mediterranean Sea: estimates, patterns, and threats. PLoS One (2010) 6.77
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features. Proc Natl Acad Sci U S A (2006) 4.52
A molecular timescale of eukaryote evolution and the rise of complex multicellular life. BMC Evol Biol (2004) 4.17
Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri. Science (2010) 3.70
Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics (2004) 3.68
The timing of eukaryotic evolution: does a relaxed molecular clock reconcile proteins and fossils? Proc Natl Acad Sci U S A (2004) 3.33
Phylogenomic analyses support the monophyly of Excavata and resolve relationships among eukaryotic "supergroups". Proc Natl Acad Sci U S A (2009) 3.02
An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81
The secretory peptide gene EPF1 enforces the stomatal one-cell-spacing rule. Genes Dev (2007) 2.68
RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members. Proc Natl Acad Sci U S A (2008) 2.65
Identification of shared single copy nuclear genes in Arabidopsis, Populus, Vitis and Oryza and their phylogenetic utility across various taxonomic levels. BMC Evol Biol (2010) 2.50
Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe (2009) 2.46
Phylogenetic and ecological analysis of novel marine stramenopiles. Appl Environ Microbiol (2004) 2.35
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res (2008) 2.32
A higher level classification of all living organisms. PLoS One (2015) 2.27
The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases. Proc Natl Acad Sci U S A (2005) 2.14
The malarial host-targeting signal is conserved in the Irish potato famine pathogen. PLoS Pathog (2006) 2.10
Three distinct modes of intron dynamics in the evolution of eukaryotes. Genome Res (2007) 2.06
Origin and diversification of basic-helix-loop-helix proteins in plants. Mol Biol Evol (2009) 2.03
Genome evolution in filamentous plant pathogens: why bigger can be better. Nat Rev Microbiol (2012) 1.93
The origin and early evolution of eukaryotes in the light of phylogenomics. Genome Biol (2010) 1.92
How many novel eukaryotic 'kingdoms'? Pitfalls and limitations of environmental DNA surveys. BMC Biol (2004) 1.89
The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate? Biol Direct (2006) 1.88
Evolution of protein complexes by duplication of homomeric interactions. Genome Biol (2007) 1.88
The Phycodnaviridae: the story of how tiny giants rule the world. Curr Top Microbiol Immunol (2009) 1.82
Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res (2005) 1.77
Protistan microbial observatory in the Cariaco Basin, Caribbean. I. Pyrosequencing vs Sanger insights into species richness. ISME J (2011) 1.76
The Microbial Rosetta Stone Database: a compilation of global and emerging infectious microorganisms and bioterrorist threat agents. BMC Microbiol (2005) 1.73
Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol (2011) 1.69
Blocking primers to enhance PCR amplification of rare sequences in mixed samples - a case study on prey DNA in Antarctic krill stomachs. Front Zool (2008) 1.68
An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis. PLoS One (2007) 1.67
Rooting the tree of life by transition analyses. Biol Direct (2006) 1.66
Novel eukaryotes from the permanently anoxic Cariaco Basin (Caribbean Sea). Appl Environ Microbiol (2003) 1.63
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum. Genome Biol (2004) 1.61
The twilight of Heliozoa and rise of Rhizaria, an emerging supergroup of amoeboid eukaryotes. Proc Natl Acad Sci U S A (2004) 1.57
The extent of protist diversity: insights from molecular ecology of freshwater eukaryotes. Proc Biol Sci (2005) 1.55
Evaluating support for the current classification of eukaryotic diversity. PLoS Genet (2006) 1.55
Diversity and distribution of marine microbial eukaryotes in the Arctic Ocean and adjacent seas. Appl Environ Microbiol (2006) 1.48
Defining DNA-based operational taxonomic units for microbial-eukaryote ecology. Appl Environ Microbiol (2009) 1.44
Invasion and intracellular survival by protozoan parasites. Immunol Rev (2011) 1.43
Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta. Genome Biol (2013) 1.41
Widespread vertical transmission and associated host sex-ratio distortion within the eukaryotic phylum Microspora. Proc Biol Sci (2004) 1.41
The evolution of extracellular matrix. Mol Biol Cell (2010) 1.40
Horizontal transfer of a nitrate assimilation gene cluster and ecological transitions in fungi: a phylogenetic study. PLoS One (2007) 1.39
Comparative genomics of the pennate diatom Phaeodactylum tricornutum. Plant Physiol (2005) 1.39
REC, Drosophila MCM8, drives formation of meiotic crossovers. PLoS Genet (2005) 1.39
Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress. Genome Biol (2009) 1.36
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes. BMC Evol Biol (2009) 1.34
Diversity patterns and activity of uncultured marine heterotrophic flagellates unveiled with pyrosequencing. ISME J (2012) 1.34
Broadly sampled multigene trees of eukaryotes. BMC Evol Biol (2008) 1.32
Evolutionary position of breviate amoebae and the primary eukaryote divergence. Proc Biol Sci (2009) 1.31
Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation. Proc Natl Acad Sci U S A (2008) 1.31
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
Evolution of NIN-like proteins in Arabidopsis, rice, and Lotus japonicus. J Mol Evol (2005) 1.27
The Biological Big Bang model for the major transitions in evolution. Biol Direct (2007) 1.25
The evolution of eukaryotic cilia and flagella as motile and sensory organelles. Adv Exp Med Biol (2007) 1.24
A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes. Nucleic Acids Res (2007) 1.23
Beringian paleoecology inferred from permafrost-preserved fungal DNA. Appl Environ Microbiol (2005) 1.22
Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes. BMC Genomics (2006) 1.21
Early evolution of histone mRNA 3' end processing. RNA (2007) 1.20
The eukaryotic tree of life from a global phylogenomic perspective. Cold Spring Harb Perspect Biol (2014) 1.20
Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol (2010) 1.19
Another place, another timer: Marine species and the rhythms of life. Bioessays (2011) 1.19
Single, ancient origin of a plastid metabolite translocator family in Plantae from an endomembrane-derived ancestor. Eukaryot Cell (2006) 1.18
Fungi and animals may share a common ancestor to nuclear receptors. Proc Natl Acad Sci U S A (2006) 1.18
Evolution of four gene families with patchy phylogenetic distributions: influx of genes into protist genomes. BMC Evol Biol (2006) 1.17
Normalisation genes for expression analyses in the brown alga model Ectocarpus siliculosus. BMC Mol Biol (2008) 1.17
Expressed sequence tags from the oomycete fish pathogen Saprolegnia parasitica reveal putative virulence factors. BMC Microbiol (2005) 1.15
The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology. Genome Biol (2011) 1.14
An ancient spliceosomal intron in the ribosomal protein L7a gene (Rpl7a) of Giardia lamblia. BMC Evol Biol (2005) 1.14
Open science resources for the discovery and analysis of Tara Oceans data. Sci Data (2015) 1.13
Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets. J Infect Dis (2012) 1.12
The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq. BMC Genomics (2013) 1.11
Novelty and spatio-temporal heterogeneity in the bacterial diversity of hypersaline Lake Tebenquiche (Salar de Atacama). Extremophiles (2008) 1.11
New insights into the phylogenetic distribution and evolutionary origins of the septins. Biol Chem (2011) 1.11
Jumbled genomes: missing Apicomplexan synteny. Mol Biol Evol (2011) 1.11
Comparing the Dictyostelium and Entamoeba genomes reveals an ancient split in the Conosa lineage. PLoS Comput Biol (2005) 1.10
Extensive differences in gene expression between symbiotic and aposymbiotic cnidarians. G3 (Bethesda) (2014) 1.09
Transcriptome analysis of a cnidarian-dinoflagellate mutualism reveals complex modulation of host gene expression. BMC Genomics (2006) 1.09
Evolutionary history and functional implications of protein domains and their combinations in eukaryotes. Genome Biol (2007) 1.09
The protein-phosphatome of the human malaria parasite Plasmodium falciparum. BMC Genomics (2008) 1.08
The chastity of amoebae: re-evaluating evidence for sex in amoeboid organisms. Proc Biol Sci (2011) 1.05
Diverse evolutionary paths to cell adhesion. Trends Cell Biol (2010) 1.05
The Hedgehog protein family. Genome Biol (2008) 1.05
Analysis of rare genomic changes does not support the unikont-bikont phylogeny and suggests cyanobacterial symbiosis as the point of primary radiation of eukaryotes. Genome Biol Evol (2009) 1.05
Flavonoids: a metabolic network mediating plants adaptation to their real estate. Front Plant Sci (2014) 1.04
Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases. Nucleic Acids Res (2006) 1.04
The origins of apicomplexan sequence innovation. Genome Res (2009) 1.03
Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Proc Natl Acad Sci U S A (2010) 1.02
Cellular differentiation and individuality in the 'minor' multicellular taxa. Biol Rev Camb Philos Soc (2013) 1.01
A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution. BMC Genomics (2007) 1.01
Mitochondrion-related organelles in eukaryotic protists. Annu Rev Microbiol (2010) 1.01
BLASTO: a tool for searching orthologous groups. Nucleic Acids Res (2007) 1.00
The VARL gene family and the evolutionary origins of the master cell-type regulatory gene, regA, in Volvox carteri. J Mol Evol (2007) 1.00
NADPH oxidases in Eukaryotes: red algae provide new hints! Curr Genet (2005) 1.00
Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins. PLoS One (2009) 1.00
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun (2016) 1.00
The complete mitochondrial genome sequence of the hornwort Megaceros aenigmaticus shows a mixed mode of conservative yet dynamic evolution in early land plant mitochondrial genomes. J Mol Evol (2009) 0.99