Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor.

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Published in Cell Death Differ on July 01, 2003

Authors

D Arnoult, M Karbowski, R J Youle

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Cell surface and intracellular functions for ricin galactose binding. J Biol Chem (1992) 1.08

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Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease. Lancet (1984) 1.07

Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol. J Biol Chem (1987) 1.06

Mitochondria in Ca2+ signaling and apoptosis. J Bioenerg Biomembr (2000) 1.03

The role of the diphtheria toxin receptor in cytosol translocation. J Biol Chem (1988) 1.03

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Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Braz J Med Biol Res (2003) 1.02

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Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding. Cancer Res (1990) 1.01

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Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. J Neurosci Res (2005) 0.99

X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution. J Mol Biol (1996) 0.97

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Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily. Cancer Res (1996) 0.97

Toxicity of an antitumor ribonuclease to Purkinje neurons. J Neurosci (1994) 0.97

Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin. Cell (1981) 0.96

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation. Blood (1985) 0.96

Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin. J Neurosurg (1987) 0.96

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun (1991) 0.96

Intraventricular immunotoxin therapy for leptomeningeal neoplasia. Neurosurgery (1997) 0.95

Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin. J Exp Med (1982) 0.94

Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins. J Biol Chem (1991) 0.94

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Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease. Biochem Biophys Res Commun (1994) 0.91

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Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin. Proc Natl Acad Sci U S A (1979) 0.90

Programmed cell death in heterokaryons. A study of the transfer of apoptosis between nuclei. Am J Pathol (1992) 0.90

Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins. J Cell Biol (1994) 0.88

The role of proline 345 in diphtheria toxin translocation. J Biol Chem (1993) 0.88

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A point mutation of proline 308 in diphtheria toxin B chain inhibits membrane translocation of toxin conjugates. J Biol Chem (1989) 0.85

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Humanization of immunotoxins. Proc Natl Acad Sci U S A (1992) 0.82

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Albumin storage protein and allergens in cottonseeds. J Agric Food Chem (1979) 0.81

Immunotoxins for brain tumor therapy. Curr Top Microbiol Immunol (1998) 0.81

The structure of diphtheria toxin as a guide to rational design. Targeted Diagn Ther (1992) 0.80

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