Published in Curr Opin Rheumatol on July 01, 2003
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2009) 4.90
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol (2005) 3.53
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol (2004) 3.43
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Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58
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PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest (2009) 2.26
Regulatory T cells in asthma. Immunity (2009) 2.00
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FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS One (2008) 1.73
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The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
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Human regulatory T cells and autoimmunity. Eur J Immunol (2008) 1.54
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Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood (2007) 1.44
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Regulatory T cells in many flavors control asthma. Mucosal Immunol (2010) 1.28
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Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. Am J Pathol (2007) 1.25
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Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology (2006) 1.21
The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J Clin Immunol (2008) 1.19
Multiple sclerosis and regulatory T cells. J Clin Immunol (2008) 1.17
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Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity. Semin Immunol (2009) 1.15
Update of human and mouse forkhead box (FOX) gene families. Hum Genomics (2010) 1.14
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep (2012) 1.14
CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses. Immunology (2005) 1.12
NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment. J Immunol (2009) 1.12
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunology (2008) 1.12
Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology (2008) 1.09
Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation. Immunology (2006) 1.07
Regulatory T cells in human autoimmune diseases. Springer Semin Immunopathol (2006) 1.07
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Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression. Respir Res (2006) 1.05
Bcl-2-regulated cell death signalling in the prevention of autoimmunity. Cell Death Dis (2010) 1.04
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin Exp Immunol (2005) 1.04
Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome. Eur J Immunol (2011) 1.03
Expression and function of TNF and IL-1 receptors on human regulatory T cells. PLoS One (2010) 1.01
Treg functional stability and its responsiveness to the microenvironment. Immunol Rev (2014) 1.01
Regulatory T cells in rheumatoid arthritis. Arthritis Res Ther (2005) 1.00
The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients. Clin Rheumatol (2010) 0.99
Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. PLoS One (2009) 0.99
Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol (2012) 0.98
IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis. Genes Immun (2010) 0.97
Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem (2008) 0.97
Expression of self-antigen in the thymus: a little goes a long way. J Exp Med (2003) 0.96
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol (2011) 0.96
CD4+CD25+ regulatory T cells in autoimmune arthritis. Immunol Rev (2010) 0.96
Harnessing FOXP3+ regulatory T cells for transplantation tolerance. J Clin Invest (2014) 0.95
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis. Am J Pathol (2009) 0.95
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Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis. Clin Immunol (2012) 0.95
Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J Autoimmun (2012) 0.94
MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function. J Biol Chem (2012) 0.93
PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer. Am J Transl Res (2010) 0.93
Autoimmunity in primary immune deficiency: taking lessons from our patients. Clin Exp Immunol (2011) 0.93
T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med (2008) 0.93
Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2014) 0.92
Targeting regulatory T cells in the treatment of type 1 diabetes mellitus. Curr Mol Med (2012) 0.92
Melanoma induces immunosuppression by up-regulating FOXP3(+) regulatory T cells. J Surg Res (2007) 0.91
Activated CD4+ CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells. Immunology (2005) 0.91
Prognostic significance of autoimmunity during treatment of melanoma with interferon. Semin Immunopathol (2011) 0.90
FOXP3 and GARP (LRRC32): the master and its minion. Biol Direct (2010) 0.90
Three distinct domains contribute to nuclear transport of murine Foxp3. PLoS One (2009) 0.90
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression. Crit Rev Immunol (2010) 0.90
Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD. Respir Res (2011) 0.89
Regulatory T cells and immune tolerance in the intestine. Cold Spring Harb Perspect Biol (2013) 0.88
Gastrointestinal and hepatic manifestations of primary immune deficiency diseases. Saudi J Gastroenterol (2010) 0.88
T regulatory cells are markers of disease activity in multiple sclerosis patients. PLoS One (2011) 0.88
Targeting regulatory T cells to improve vaccine immunogenicity in early life. Front Microbiol (2014) 0.88
The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression. Adv Pharmacol (2013) 0.87
Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children. Clin Exp Immunol (2010) 0.87
Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease. Biol Blood Marrow Transplant (2010) 0.86
Prospective immunological profiling in a case of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX). Clin Exp Immunol (2004) 0.86
Epigenetic regulation of cytokine gene expression in T lymphocytes. Yonsei Med J (2009) 0.86
Regulatory T cells in type 1 autoimmune pancreatitis. Int J Rheumatol (2012) 0.85
The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer. Adv Exp Med Biol (2009) 0.85
Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1. Mol Endocrinol (2009) 0.85
Beneficial role of rapamycin in experimental autoimmune myositis. PLoS One (2013) 0.85
Recognition of self and altered self by T cells in autoimmunity and allergy. Protein Cell (2013) 0.85
Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB. PLoS One (2012) 0.84
FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases. Front Immunol (2015) 0.83
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development. Pediatr Rheumatol Online J (2008) 0.83
Thymic epithelial cell development and its dysfunction in human diseases. Biomed Res Int (2014) 0.83
Medium-term survival without haematopoietic stem cell transplantation in a case of IPEX: insights into nutritional and immunosuppressive therapy. Eur J Pediatr (2007) 0.83
A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon. PLoS One (2012) 0.82
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A (2006) 5.50
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity (2006) 4.75
Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70
Transcellular diapedesis is initiated by invasive podosomes. Immunity (2007) 4.06
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol (2003) 3.81
Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol (2009) 3.70
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol (2007) 2.98
Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis (2010) 2.69
X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine (Baltimore) (2006) 2.66
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol (2008) 2.50
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J Immunol (2006) 2.44
Clinical course of patients with WASP gene mutations. Blood (2003) 2.06
Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations. Nat Genet (2005) 1.99
FOXP3 acts as a rheostat of the immune response. Immunol Rev (2005) 1.86
Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement. Nat Med (2002) 1.80
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation. Blood (2004) 1.78
Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol (2006) 1.71
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol (2012) 1.70
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc Natl Acad Sci U S A (2007) 1.70
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice. Blood (2009) 1.68
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol (2007) 1.67
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood (2008) 1.65
Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment. Clin Immunol (2002) 1.64
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair. Proc Natl Acad Sci U S A (2010) 1.62
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J Exp Med (2007) 1.61
Wiskott-Aldrich syndrome. Curr Opin Hematol (2008) 1.59
Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol (2011) 1.57
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood (2012) 1.53
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res (2007) 1.51
X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options. Blood (2010) 1.51
Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. Clin Immunol (2003) 1.49
Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study. J Invest Dermatol (2008) 1.46
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood (2004) 1.40
Effect of rituximab on human in vivo antibody immune responses. J Allergy Clin Immunol (2011) 1.39
DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol (2015) 1.32
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol (2013) 1.31
Absence of memory B cells in patients with common variable immunodeficiency. Clin Immunol (2002) 1.30
A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. J Clin Immunol (2013) 1.27
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice. Mol Ther (2004) 1.24
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. J Allergy Clin Immunol (2009) 1.23
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology (2007) 1.23
Rituximab inhibits the in vivo primary and secondary antibody response to a neoantigen, bacteriophage phiX174. Am J Transplant (2005) 1.19
First report of the Hyper-IgM syndrome Registry of the Latin American Society for Immunodeficiencies: novel mutations, unique infections, and outcomes. J Clin Immunol (2014) 1.18
TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol (2009) 1.18
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice. Blood (2008) 1.17
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study. J Am Acad Dermatol (2003) 1.16
The hyper IgM syndrome--an evolving story. Pediatr Res (2004) 1.15
Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy. Gastroenterology (2010) 1.15
Home-based subcutaneous immunoglobulin versus hospital-based intravenous immunoglobulin in treatment of primary antibody deficiencies: systematic review and meta analysis. J Clin Immunol (2012) 1.11
Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease. Ther Clin Risk Manag (2010) 1.10
WAVE/Scars in platelets. Blood (2004) 1.09
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med (2009) 1.09
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice. Blood (2006) 1.08
The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies. J Autoimmun (2010) 1.07
Clinical spectrum, pathophysiology and treatment of the Wiskott-Aldrich syndrome. Curr Opin Hematol (2011) 1.06
Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients. J Clin Immunol (2011) 1.04
Prioritization of evidence-based indications for intravenous immunoglobulin. J Clin Immunol (2013) 1.04
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy. Blood (2009) 1.03
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol (2010) 1.03
Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion. EMBO Rep (2006) 1.02
Autoimmunity and inflammation in X-linked agammaglobulinemia. J Clin Immunol (2014) 1.01
Wiskott-Aldrich Syndrome: a model for defective actin reorganization, cell trafficking and synapse formation. Curr Opin Immunol (2003) 1.01
STAT3 mutation in the original patient with Job's syndrome. N Engl J Med (2007) 0.99
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. Blood (2012) 0.99
WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype. Curr Opin Allergy Clin Immunol (2003) 0.99
Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations. Clin Immunol (2007) 0.98
Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia. Blood (2002) 0.96
Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). J Pediatr (2005) 0.96
Intraarticular corticosteroid injections of the temporomandibular joint in juvenile idiopathic arthritis. J Rheumatol (2008) 0.95
Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Dermatol (2004) 0.95
Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families. Hum Genet (2003) 0.95
FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages. J Biol Chem (2009) 0.95
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. J Allergy Clin Immunol (2010) 0.95
Autoantibodies in scurfy mice and IPEX patients recognize keratin 14. J Invest Dermatol (2010) 0.94
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol (2009) 0.93
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol (2009) 0.91
Controversies in IgG replacement therapy in patients with antibody deficiency diseases. J Allergy Clin Immunol (2013) 0.90
Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines. J Allergy Clin Immunol (2009) 0.90
Regulatory T cells in primary immunodeficiency diseases. Curr Opin Allergy Clin Immunol (2007) 0.89
Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells. Hum Immunol (2008) 0.89
Cutaneous noncaseating granulomas associated with Nijmegen breakage syndrome. Arch Dermatol (2008) 0.89
Comèl-Netherton syndrome defined as primary immunodeficiency. J Allergy Clin Immunol (2009) 0.88