Published in Blood on June 26, 2003
Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24
Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med (2011) 4.51
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest (2005) 3.93
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med (2007) 2.71
A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol (2010) 2.36
Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J Immunol (2011) 2.16
TLR-based immune adjuvants. Vaccine (2010) 2.10
Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am (2009) 2.01
The multifaceted functions of neutrophils. Annu Rev Pathol (2013) 1.97
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med (2010) 1.88
Pattern recognition receptors and the innate immune response to viral infection. Viruses (2011) 1.82
Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol (2008) 1.81
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest (2007) 1.67
Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury. Hepatology (2010) 1.60
Toll-like receptor agonists in cancer therapy. Immunotherapy (2009) 1.58
Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation (2009) 1.56
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog (2012) 1.52
Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease. Invest Ophthalmol Vis Sci (2012) 1.49
Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun (2006) 1.43
Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L. Blood (2005) 1.42
Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma. Respirology (2015) 1.41
Role of neutrophils in innate immunity: a systems biology-level approach. Wiley Interdiscip Rev Syst Biol Med (2010) 1.37
Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps. Infect Immun (2010) 1.35
Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog (2015) 1.35
Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Respir Res (2009) 1.29
The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. PLoS Genet (2011) 1.27
Neutrophil-derived cytokines: facts beyond expression. Front Immunol (2014) 1.25
Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood (2008) 1.24
Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages. Int J Med Sci (2008) 1.24
Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol (2013) 1.23
Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun (2005) 1.23
Neutrophils in innate and adaptive immunity. Semin Immunopathol (2013) 1.23
Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production. Immunology (2009) 1.23
Neutrophils in periodontal inflammation. Front Oral Biol (2011) 1.19
Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol (2004) 1.14
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils. Eur J Immunol (2010) 1.12
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection. Infect Immun (2010) 1.12
TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients. Clin Cancer Res (2015) 1.10
Comparison of the immunostimulatory and proinflammatory activities of candidate Gram-positive endotoxins, lipoteichoic acid, peptidoglycan, and lipopeptides, in murine and human cells. Immunol Lett (2008) 1.08
TLR2-mediated activation of neutrophils in response to German cockroach frass. J Immunol (2008) 1.08
Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice. Antimicrob Agents Chemother (2006) 1.07
Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog (2013) 1.06
Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am J Reprod Immunol (2004) 1.05
Macrophages in tuberculosis: friend or foe. Semin Immunopathol (2013) 1.04
Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04
Toll-like receptors and myocardial inflammation. Int J Inflam (2011) 1.03
The expression and function of Nod-like receptors in neutrophils. Immunology (2009) 1.03
Toll-like receptors in leishmania infections: guardians or promoters? J Parasitol Res (2012) 1.03
Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol (2013) 1.03
Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. RNA (2009) 1.02
Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology (2013) 1.00
Pattern-recognition receptors in human eosinophils. Immunology (2012) 1.00
Regulation of wound healing and organ fibrosis by toll-like receptors. Biochim Biophys Acta (2012) 0.99
The multiple facets of toll-like receptors in transplantation biology. Transplantation (2008) 0.99
Neutrophil roles in left ventricular remodeling following myocardial infarction. Fibrogenesis Tissue Repair (2013) 0.99
Heat-shock proteins as dendritic cell-targeting vaccines--getting warmer. Immunology (2013) 0.98
The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes. Clin Exp Immunol (2009) 0.98
IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1. PLoS One (2013) 0.98
Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis. PLoS Pathog (2012) 0.98
Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol (2008) 0.97
Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88. Infect Immun (2006) 0.97
Deciphering mechanisms of staphylococcal biofilm evasion of host immunity. Front Cell Infect Microbiol (2012) 0.97
Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection. Infect Immun (2011) 0.96
Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. Immunology (2007) 0.96
Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major. Infect Immun (2004) 0.95
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog (2009) 0.95
Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Infect Immun (2007) 0.95
The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases. BMC Immunol (2014) 0.95
Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity. Am J Respir Crit Care Med (2014) 0.94
Increased immunoglobulin A in alcoholic liver cirrhosis: exploring the response of B cells to Toll-like receptor 9 activation. Clin Exp Immunol (2009) 0.93
Neutrophil-Mediated Phagocytosis of Staphylococcus aureus. Front Immunol (2014) 0.93
Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol (2009) 0.93
Interactions among type I and type II interferon, tumor necrosis factor, and beta-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus. Arthritis Res Ther (2009) 0.93
Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis. Expert Rev Mol Med (2008) 0.93
Role of Toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol (2008) 0.93
Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis. Blood (2015) 0.93
The function of TLR2 during staphylococcal diseases. Front Cell Infect Microbiol (2013) 0.92
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4. Immunology (2005) 0.92
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology (2006) 0.91
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Mol Med (2013) 0.90
Vaccine Development Against Leishmania donovani. Front Immunol (2012) 0.90
The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation. Am J Pathol (2015) 0.90
Oral neutrophil transcriptome changes result in a pro-survival phenotype in periodontal diseases. PLoS One (2013) 0.90
Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage. Antimicrob Agents Chemother (2007) 0.89
Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia. J Immunol (2009) 0.89
CD47 and TLR-2 cross-talk regulates neutrophil transmigration. J Immunol (2009) 0.89
TLR signaling and effector functions are intact in XLA neutrophils. Clin Immunol (2010) 0.89
Burn-induced alterations in toll-like receptor-mediated responses by bronchoalveolar lavage cells. Cytokine (2011) 0.89
Direct stimulatory effects of the TLR2/6 ligand bacterial lipopeptide MALP-2 on neutrophil granulocytes. Med Microbiol Immunol (2006) 0.88
Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem (2012) 0.88
Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils. Infect Immun (2007) 0.88
Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils. Immunology (2014) 0.87
Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes. J Appl Physiol (1985) (2015) 0.87
Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun (2006) 0.87
Toll gates to periodontal host modulation and vaccine therapy. Periodontol 2000 (2009) 0.87
Neutrophils come of age in chronic inflammation. Curr Opin Immunol (2012) 0.87
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med (2007) 5.06
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol (2002) 4.81
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med (2004) 4.29
Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol (2008) 4.17
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest (2005) 3.93
CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol Cell Biol (2011) 3.73
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A (2003) 3.72
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity (2010) 3.67
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol (2005) 3.63
HIV-infected T cells are migratory vehicles for viral dissemination. Nature (2012) 3.57
Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol (2005) 3.31
Chemokines and their receptors: drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol (2008) 3.04
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem (2002) 2.85
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 2.73
The microglial sensome revealed by direct RNA sequencing. Nat Neurosci (2013) 2.73
Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol (2014) 2.71
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res (2007) 2.66
CD36 mediates the innate host response to beta-amyloid. J Exp Med (2003) 2.65
CXCR3 in T cell function. Exp Cell Res (2011) 2.54
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol (2003) 2.39
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. Nature (2012) 2.38
Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol (2006) 2.37
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet (2004) 2.36
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol (2002) 2.22
Neutrophils cascading their way to inflammation. Trends Immunol (2011) 2.19
A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med (2006) 2.15
Bacterial c-di-GMP is an immunostimulatory molecule. J Immunol (2007) 2.13
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev (2013) 2.11
Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A (2008) 2.08
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol (2004) 2.06
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation (2006) 1.95
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest (2011) 1.92
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat Immunol (2003) 1.86
CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity (2012) 1.85
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med (2009) 1.84
Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J Biol Chem (2004) 1.81
BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids (2003) 1.79
T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol (2008) 1.76
CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol (2003) 1.76
Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci (2008) 1.71
Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes. Cell (2012) 1.70
Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology. Chest (2013) 1.68
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol (2011) 1.66
Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest (2003) 1.66
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol (2009) 1.65
T cell homing to epithelial barriers in allergic disease. Nat Med (2012) 1.58
18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med (2011) 1.53
Antiangiogenic and antitumor activities of IL-27. J Immunol (2006) 1.50
CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med (2014) 1.50
IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol (2002) 1.48
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med (2011) 1.47
Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med (2013) 1.47
CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology (2008) 1.46
Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Res Ther (2010) 1.46
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog (2006) 1.45
Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. J Immunol (2004) 1.44
Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol (2006) 1.44
Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. J Leukoc Biol (2011) 1.44
CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. Mol Cell Biol (2006) 1.42
CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med (2007) 1.41
P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev (2003) 1.41
Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway. J Immunol (2007) 1.41
Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity. J Immunol (2006) 1.41
Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation (2009) 1.40
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. J Clin Invest (2010) 1.38
Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol (2006) 1.38
Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J Immunol (2012) 1.35
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation (2005) 1.34
T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol (2006) 1.31
Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol (2009) 1.29
The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol (2013) 1.29
Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res (2009) 1.28
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol (2007) 1.27
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol (2009) 1.26
Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun (2005) 1.25
Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. J Allergy Clin Immunol (2008) 1.25
Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Sci Transl Med (2012) 1.21
Thymocyte emigration is mediated by active movement away from stroma-derived factors. J Clin Invest (2002) 1.20
Invariant natural killer T cells in bronchial asthma. N Engl J Med (2006) 1.19
Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol (2004) 1.19
Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. J Immunol (2005) 1.18
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum (2011) 1.18