Published in Nat Immunol on August 31, 2003
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity (2010) 3.67
Regional and mucosal memory T cells. Nat Immunol (2011) 2.21
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med (2007) 1.96
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol (2011) 1.66
T cell homing to epithelial barriers in allergic disease. Nat Med (2012) 1.58
A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A (2006) 1.55
Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. J Leukoc Biol (2011) 1.44
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad Sci U S A (2005) 1.41
Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol (2005) 1.31
Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. J Exp Med (2005) 1.30
Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A (2004) 1.30
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol (2009) 1.26
Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest (2004) 1.26
Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest (2011) 1.24
Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function. Blood (2006) 1.23
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J Exp Med (2005) 1.23
Mast cells in inflammatory arthritis. Arthritis Res Ther (2004) 1.21
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med (2005) 1.16
An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol (2010) 1.16
The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A (2008) 1.14
NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol (2011) 1.13
Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. Microbes Infect (2007) 1.13
Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.13
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity (2012) 1.09
Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics (2012) 1.09
Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. Proc Natl Acad Sci U S A (2006) 1.08
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood (2005) 1.06
The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood (2005) 1.01
FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood (2009) 0.98
Targeting cells in motion: migrating toward improved therapies. Eur J Immunol (2013) 0.98
Role of leukotriene B4 receptors in rheumatoid arthritis. Autoimmun Rev (2007) 0.95
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol (2012) 0.94
Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli. J Leukoc Biol (2009) 0.94
Sperm and oocyte communication mechanisms controlling C. elegans fertility. Dev Dyn (2010) 0.94
Leukotriene B4 release from mast cells in IgE-mediated airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol (2008) 0.93
Bioactive lipids in Trypanosoma cruzi infection. Adv Parasitol (2011) 0.93
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase. Br J Pharmacol (2007) 0.93
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci U S A (2006) 0.92
Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. J Immunol (2015) 0.90
Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity. J Immunol (2013) 0.89
High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes. BMC Immunol (2009) 0.88
Polyunsaturated Fatty Acid-derived lipid mediators and T cell function. Front Immunol (2014) 0.88
Ir-LBP, an ixodes ricinus tick salivary LTB4-binding lipocalin, interferes with host neutrophil function. PLoS One (2008) 0.88
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. PLoS One (2012) 0.88
Leukotrienes and airway inflammation. Biochim Biophys Acta (2011) 0.88
Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. Sci Signal (2015) 0.87
Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. J Immunol (2014) 0.87
Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Front Immunol (2013) 0.87
Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase. Immunology (2007) 0.85
Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Med (2014) 0.83
In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response. Clin Exp Allergy (2008) 0.83
Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease. Am J Respir Cell Mol Biol (2011) 0.82
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. Am J Pathol (2010) 0.82
Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets. Mediators Inflamm (2012) 0.81
Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. J Immunol (2011) 0.81
BLT for speed. Nat Immunol (2003) 0.80
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis (2013) 0.80
The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component. Br J Pharmacol (2004) 0.79
Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. Allergy (2011) 0.79
Mast cells and the adaptive immune response. J Clin Immunol (2008) 0.79
The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis. PLoS One (2014) 0.79
Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS One (2013) 0.79
Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells. Immunology (2015) 0.79
Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation. BMC Immunol (2008) 0.78
The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Mol Pain (2015) 0.77
Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. Antimicrob Agents Chemother (2014) 0.77
Experimental advances in understanding allergic airway inflammation. Front Biosci (Schol Ed) (2013) 0.77
Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection. PLoS One (2015) 0.76
Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration. Mediators Inflamm (2015) 0.76
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol (2015) 0.76
Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection. Virol J (2013) 0.76
Leukotriene enhanced allergic lung inflammation through induction of chemokine production. Clin Exp Med (2014) 0.76
Biochemical characterization of three BLT receptors in zebrafish. PLoS One (2015) 0.75
Clostridium difficile-induced colitis in mice is independent of leukotrienes. Anaerobe (2014) 0.75
Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. Int J Mol Sci (2017) 0.75
The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Mediators Inflamm (2014) 0.75
Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS One (2017) 0.75
The yin and yang of leukotriene B4 mediated inflammation in cancer. Semin Immunol (2017) 0.75
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell (2013) 6.35
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science (2010) 5.77
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med (2007) 5.06
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol (2002) 4.81
Toll-like receptors stimulate human neutrophil function. Blood (2003) 4.29
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med (2004) 4.29
Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol (2008) 4.17
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest (2005) 3.93
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol (2008) 3.82
CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol Cell Biol (2011) 3.73
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A (2003) 3.72
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity (2010) 3.67
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol (2005) 3.63
HIV-infected T cells are migratory vehicles for viral dissemination. Nature (2012) 3.57
Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol (2005) 3.31
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest (2011) 3.23
Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation (2005) 3.16
Chemokines and their receptors: drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol (2008) 3.04
Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature (2013) 2.85
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem (2002) 2.85
Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. J Am Coll Cardiol (2011) 2.83
Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry. Clin Chem (2009) 2.77
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 2.73
Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab. Circ Cardiovasc Imaging (2012) 2.72
Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol (2014) 2.71
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res (2007) 2.66
CD36 mediates the innate host response to beta-amyloid. J Exp Med (2003) 2.65
Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation (2007) 2.58
CXCR3 in T cell function. Exp Cell Res (2011) 2.54
Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation (2012) 2.51
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest (2008) 2.46
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease. Nat Biotechnol (2011) 2.44
Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution. Mol Cell Proteomics (2009) 2.42
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. Nature (2012) 2.38
Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol (2006) 2.37
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet (2004) 2.36
Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol (2012) 2.26
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol (2002) 2.22
Neutrophils cascading their way to inflammation. Trends Immunol (2011) 2.19
A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med (2006) 2.15
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest (2013) 2.15
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev (2013) 2.11
Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A (2008) 2.08
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol (2004) 2.06
Metabolic signatures of exercise in human plasma. Sci Transl Med (2010) 1.99
Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction. Circulation (2008) 1.95
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation (2006) 1.95
Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol (2011) 1.93
Application of metabolomics to cardiovascular biomarker and pathway discovery. J Am Coll Cardiol (2008) 1.92
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest (2011) 1.92
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol (2002) 1.87
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat Immunol (2003) 1.86
CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity (2012) 1.85
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med (2009) 1.84
Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J Biol Chem (2004) 1.81
BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids (2003) 1.79
T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol (2008) 1.76
CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol (2003) 1.76
Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci (2008) 1.71
Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes. Cell (2012) 1.70
Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest (2003) 1.69
Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology. Chest (2013) 1.68
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol (2011) 1.66
Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest (2003) 1.66
Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arterioscler Thromb Vasc Biol (2011) 1.66
Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis. Circulation (2013) 1.65
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol (2009) 1.65
In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology. Biochem Biophys Res Commun (2005) 1.65
Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy. Mol Ther (2010) 1.63
Metabolite profiling identifies markers of uremia. J Am Soc Nephrol (2010) 1.63
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem (2006) 1.58
T cell homing to epithelial barriers in allergic disease. Nat Med (2012) 1.58
18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med (2011) 1.53
Antiangiogenic and antitumor activities of IL-27. J Immunol (2006) 1.50
CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med (2014) 1.50
IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol (2002) 1.48
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med (2011) 1.47
A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J (2012) 1.47
Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med (2013) 1.47
CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology (2008) 1.46
Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Res Ther (2010) 1.46
Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol (2004) 1.46
Correction of the biochemical and functional deficits in fabry mice following AAV8-mediated hepatic expression of alpha-galactosidase A. Mol Ther (2006) 1.46
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog (2006) 1.45
Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol (2006) 1.44
Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. J Immunol (2004) 1.44