Published in Hepatology on July 01, 2003
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A (2008) 4.57
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol (2006) 3.46
Nonalcoholic fatty liver disease. CMAJ (2005) 2.56
Benefits of lifestyle modification in NAFLD. Gut (2007) 1.59
Genetic determinants of hepatic steatosis in man. J Lipid Res (2011) 1.52
Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease. Am J Gastroenterol (2010) 1.17
NASH--hepatic metabolism and not simply the metabolic syndrome. Hepatology (2003) 1.01
The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology (2012) 1.00
Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: a case report. World J Gastroenterol (2005) 0.96
The blind men 'see' the elephant-the many faces of fatty liver disease. World J Gastroenterol (2008) 0.94
Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch (2003) 0.93
Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis. BMC Genomics (2008) 0.91
Amiodarone-induced cirrhosis of liver: what predicts mortality? ISRN Cardiol (2013) 0.87
Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. Exp Cell Res (2008) 0.86
Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Prog Lipid Res (2015) 0.84
Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. J Lipid Res (2012) 0.84
Ω-3 fatty acids prevent hepatic steatosis, independent of PPAR-α activity, in a murine model of parenteral nutrition-associated liver disease. JPEN J Parenter Enteral Nutr (2013) 0.83
Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis. Br J Pharmacol (2012) 0.83
Identification of novel clinical factors associated with hepatic fat accumulation in extreme obesity. J Obes (2014) 0.82
Mechanistic review of drug-induced steatohepatitis. Toxicol Appl Pharmacol (2015) 0.82
Enhanced amelioration of high-fat diet-induced fatty liver by docosahexaenoic acid and lysine supplementations. Biomed Res Int (2014) 0.82
Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance. J Physiol (2005) 0.79
Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model. BMC Gastroenterol (2015) 0.78
Drug-induced steatohepatitis. Clin Liver Dis (2013) 0.78
Nutrigenomics therapy of hepatisis C virus induced-hepatosteatosis. BMC Gastroenterol (2010) 0.78
Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution. BMC Gastroenterol (2015) 0.77
The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet. Lipids Health Dis (2012) 0.77
High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis. Stem Cells Int (2016) 0.77
Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease. Hepatol Int (2008) 0.75
Ameliorative effects of glycine in an experimental nonalcoholic steatohepatitis and its correlation between TREM-1 and TREM-2. Am J Transl Res (2016) 0.75
Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis. Arterioscler Thromb Vasc Biol (2017) 0.75
Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther (2015) 0.75
Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. J Clin Transl Res (2017) 0.75
Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13
Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J (2002) 3.06
The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics (2003) 2.87
Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion (2006) 2.68
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41
Autophagy in liver diseases. J Hepatol (2010) 2.06
NASH: a mitochondrial disease. J Hepatol (2005) 1.45
The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability. Pharmacogenet Genomics (2005) 1.45
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology (2013) 1.42
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. J Pathol (2010) 1.41
The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9. Glycobiology (2006) 1.39
Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology (2002) 1.35
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies. Fundam Clin Pharmacol (2008) 1.34
Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J Hepatol (2010) 1.32
Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis. Gastroenterology (2007) 1.31
Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study. Am J Epidemiol (2012) 1.28
Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2002) 1.27
Mitochondrial injury in steatohepatitis. Eur J Gastroenterol Hepatol (2004) 1.26
Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol Clin Exp Res (2002) 1.23
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. J Clin Invest (2015) 1.17
Central role of mitochondria in drug-induced liver injury. Drug Metab Rev (2011) 1.10
Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations. Antivir Ther (2004) 1.07
PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis. J Hepatol (2012) 1.06
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology (2013) 1.02
Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis. Glycobiology (2008) 1.01
Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS Lett (2005) 1.00
Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver. J Pharmacol Exp Ther (2007) 1.00
Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells. Hepatology (2011) 0.99
Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice. Hepatology (2005) 0.98
Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells. World J Gastroenterol (2006) 0.97
Mitochondrial involvement in drug-induced liver injury. Handb Exp Pharmacol (2010) 0.97
Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model. J Hepatol (2003) 0.96
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet. Int J Exp Pathol (2011) 0.96
Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver. Lab Invest (2011) 0.95
Lipopolysaccharide-induced mitochondrial DNA depletion. Antioxid Redox Signal (2011) 0.95
Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int J Cancer (2010) 0.95
ESM-1 expression in stromal cells is predictive of recurrence after radiofrequency ablation in early hepatocellular carcinoma. J Hepatol (2013) 0.95
PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis. Hepatology (2012) 0.94
Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. Cancer Res (2006) 0.94
Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase. J Pharmacol Exp Ther (2009) 0.93
Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor. FEBS Lett (2006) 0.93
Serum proteoglycans as prognostic biomarkers of hepatocellular carcinoma in patients with alcoholic cirrhosis. Cancer Epidemiol Biomarkers Prev (2013) 0.93
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol (2012) 0.93
Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Hepatology (2009) 0.93
Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells. Biochim Biophys Acta (2009) 0.93
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity. FEBS J (2011) 0.91
Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values. J Clin Endocrinol Metab (2014) 0.91
Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency. Obesity (Silver Spring) (2008) 0.90
Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am J Physiol Endocrinol Metab (2008) 0.90
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments. Antimicrob Agents Chemother (2003) 0.90
Current challenges and controversies in drug-induced liver injury. Drug Saf (2012) 0.90
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice. Am J Pathol (2009) 0.90
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates. Toxicol Appl Pharmacol (2008) 0.90
Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death. Clin Gastroenterol Hepatol (2005) 0.89
Angiogenic properties of the chemokine RANTES/CCL5. Biochem Soc Trans (2011) 0.89
Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis. World J Gastroenterol (2008) 0.89
Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. Toxicol In Vitro (2010) 0.89
Changes in autophagic response in patients with chronic hepatitis C virus infection. Am J Pathol (2011) 0.89
Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells. Glycobiology (2009) 0.89
Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria. Toxicol Sci (2012) 0.89
RANTES (CCL5) induces a CCR5-dependent accelerated shedding of syndecan-1 (CD138) and syndecan-4 from HeLa cells and forms complexes with the shed ectodomains of these proteoglycans as well as with those of CD44. Glycobiology (2004) 0.87
Mitochondria are sensors for HIV drugs. Trends Pharmacol Sci (2005) 0.87
Impact of improvement efforts on glycemic control and hypoglycemia at a university medical center. J Hosp Med (2009) 0.86
MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice. Dig Dis (2011) 0.85
Mitochondrial DNA maintenance is regulated in human hepatoma cells by glycogen synthase kinase 3β and p53 in response to tumor necrosis factor α. PLoS One (2012) 0.85
Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation. Toxicol Appl Pharmacol (2008) 0.85
Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells. Biochim Biophys Acta (2009) 0.84
Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response. Rejuvenation Res (2011) 0.84
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. Hepatology (2003) 0.84
Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression. Biochem Pharmacol (2010) 0.84
High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes. Toxicol In Vitro (2008) 0.84
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. J Pharmacol Exp Ther (2012) 0.84