Published in Curr Biol on July 01, 2003
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A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel. Structure (2009) 1.11
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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife (2015) 0.86
Extended ubiquitin species are protein-based DUB inhibitors. Nat Chem Biol (2014) 0.86
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Nuclear import of an intact preassembled proteasome particle. Mol Biol Cell (2011) 0.83
The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome. J Biol Chem (2013) 0.83
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Spg5 protein regulates the proteasome in quiescence. J Biol Chem (2012) 0.80
Understanding the mechanism of proteasome 20S core particle gating. Proc Natl Acad Sci U S A (2014) 0.79
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Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex. Biomolecules (2014) 0.79
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Integrity of the Saccharomyces cerevisiae Rpn11 protein is critical for formation of proteasome storage granules (PSG) and survival in stationary phase. PLoS One (2013) 0.78
N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. Mol Cell Biol (2014) 0.76
Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol (2016) 0.76
The Logic of the 26S Proteasome. Cell (2017) 0.76
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The Cdc48-Vms1 complex maintains 26S proteasome architecture. Biochem J (2014) 0.75
Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast. Mol Biol Cell (2017) 0.75
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol (2006) 4.25
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06
A ubiquitin stress response induces altered proteasome composition. Cell (2007) 3.82
Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol (2005) 3.38
Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol (2002) 3.34
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell (2006) 2.87
Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem (2004) 2.85
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem (2002) 2.43
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol (2003) 2.29
Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome. Mol Cell (2010) 2.13
Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome. Mol Cell (2008) 2.12
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
A stress-responsive system for mitochondrial protein degradation. Mol Cell (2010) 2.05
Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem (2005) 2.01
Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature (2009) 1.97
Characterization of the proteasome using native gel electrophoresis. Methods Enzymol (2005) 1.89
Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nat Struct Mol Biol (2007) 1.89
A proteasome for all occasions. FEBS Lett (2007) 1.84
The central unit within the 19S regulatory particle of the proteasome. Nat Struct Mol Biol (2008) 1.82
Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome. J Biol Chem (2003) 1.80
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78
The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings. Structure (2012) 1.78
Localization to the proteasome is sufficient for degradation. J Biol Chem (2004) 1.72
Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion. Mol Biol Cell (2008) 1.66
Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 1.61
Ubiquitin-proteasome system and mitochondria - reciprocity. Biochim Biophys Acta (2010) 1.58
Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem (2004) 1.58
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol Biol (2005) 1.48
Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensor. Mol Cell (2009) 1.47
Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Mol Cell (2012) 1.46
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol (2012) 1.46
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell (2009) 1.45
A window of opportunity: timing protein degradation by trimming of sugars and ubiquitins. Trends Biochem Sci (2005) 1.39
Deubiquitinating enzymes are IN/(trinsic to proteasome function). Curr Protein Pept Sci (2004) 1.37
An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol (2011) 1.36
PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika. Mol Cell (2009) 1.31
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol Cell (2010) 1.29
Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem (2005) 1.26
Ubiquitin homeostasis is critical for synaptic development and function. J Neurosci (2011) 1.26
Electron microscopic evidence in support of alpha-solenoid models of proteasomal subunits Rpn1 and Rpn2. J Mol Biol (2009) 1.25
A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Mol Cell Proteomics (2011) 1.25
Proteasomal AAA-ATPases: structure and function. Biochim Biophys Acta (2011) 1.22
Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Biochem J (2004) 1.18
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. J Biol Chem (2012) 1.15
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J (2011) 1.13
Mixed-linkage ubiquitin chains send mixed messages. Structure (2013) 1.09
COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep (2002) 1.07
Role of a ubiquitin-like modification in polarized morphogenesis. Science (2002) 1.06
Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function. Mol Biol Cell (2008) 1.05
The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Int J Biochem Cell Biol (2003) 1.05
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response. J Biol Chem (2011) 1.04
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem (2011) 1.01
Chaperone-driven proteasome assembly. Biochem Soc Trans (2008) 1.00
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest (2014) 1.00
Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr Biol (2004) 0.98
Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci (2011) 0.97
Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem (2002) 0.97
Reconfiguration of the proteasome during chaperone-mediated assembly. Nature (2013) 0.96
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
Assembly manual for the proteasome regulatory particle: the first draft. Biochem Soc Trans (2010) 0.91
Proteasome activator 200: the heat is on... Mol Cell Proteomics (2011) 0.88
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem (2008) 0.88
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell (2013) 0.88
Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 binding. Structure (2013) 0.87
A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res (2012) 0.87
Blm10 facilitates nuclear import of proteasome core particles. EMBO J (2013) 0.85
Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome. Mol Biol Cell (2011) 0.83
Nuclear import of an intact preassembled proteasome particle. Mol Biol Cell (2011) 0.83
A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14. Curr Protoc Chem Biol (2012) 0.83
Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem (2013) 0.83
Ubiquitin chained and crosslinked. Nat Cell Biol (2002) 0.83
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem (2014) 0.82
Spg5 protein regulates the proteasome in quiescence. J Biol Chem (2012) 0.80
Binding of ubiquitin conjugates to proteasomes as visualized with native gels. Methods Mol Biol (2012) 0.78
Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases. Chemistry (2015) 0.78
Cell biology: Destruction deconstructed. Nature (2012) 0.78
Cell biology. An ancient portal to proteolysis. Science (2012) 0.77
Forging a proteasome alpha-ring with dedicated proteasome chaperones. Nat Struct Mol Biol (2008) 0.76
Misfolded proteins driven to destruction by Hul5. Nat Cell Biol (2011) 0.76
Ubiquitin proteasome system in stress and disease. Biochem Res Int (2012) 0.76
Varshavsky's contributions. Science (2004) 0.75