Published in J Neurosci on November 30, 2011
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding. Wiley Interdiscip Rev Syst Biol Med (2012) 1.81
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number. J Physiol (2013) 1.04
An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci (2014) 1.01
Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14. Am J Physiol Cell Physiol (2011) 0.98
The role of deubiquitinating enzymes in synaptic function and nervous system diseases. Neural Plast (2012) 0.93
Functions of the 19S complex in proteasomal degradation. Trends Biochem Sci (2013) 0.90
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction. Mol Neurodegener (2015) 0.89
The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration. Aging Cell (2015) 0.89
Neuronal ubiquitin homeostasis. Cell Biochem Biophys (2013) 0.88
Cellular ubiquitin pool dynamics and homeostasis. BMB Rep (2014) 0.87
Proteomics of protein post-translational modifications implicated in neurodegeneration. Transl Neurodegener (2014) 0.86
The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory. Learn Mem (2014) 0.83
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates. J Cell Biol (2016) 0.82
How does ubiquitin regulate synapses? Let me count the ways. J Physiol (2014) 0.81
Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One (2013) 0.80
Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression. J Physiol (2016) 0.79
Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14. Front Mol Neurosci (2015) 0.79
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells. Hum Mol Genet (2014) 0.78
Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14). PLoS One (2013) 0.77
Visual sensorial impairments in neurodevelopmental disorders: evidence for a retinal phenotype in Fragile X Syndrome. PLoS One (2014) 0.77
Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds. Oncoscience (2015) 0.77
The Logic of the 26S Proteasome. Cell (2017) 0.76
Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis. J Cell Biol (2016) 0.75
A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PLoS One (2014) 0.75
USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. J Biol Chem (2016) 0.75
Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC). Front Mol Neurosci (2016) 0.75
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia. Ageing Res Rev (2016) 0.75
Meddling with Fate: The Proteasomal Deubiquitinating Enzymes. J Mol Biol (2017) 0.75
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta (2017) 0.75
Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival. Nat Commun (2017) 0.75
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev (2002) 16.10
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell (1987) 6.73
Development of the vertebrate neuromuscular junction. Annu Rev Neurosci (1999) 5.81
Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell (2009) 5.44
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron (2003) 3.78
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J (2001) 3.42
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21
Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron (2006) 3.17
Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature (2001) 2.70
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol Rev (2007) 2.11
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol Cell (2009) 2.10
Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. J Biol Chem (1980) 1.99
Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron (2004) 1.91
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79
Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J Biol Chem (2002) 1.74
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem (2005) 1.71
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell (2007) 1.60
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J (2007) 1.56
Ubiquitin mRNA is a major stress-induced transcript in mammalian cells. Nucleic Acids Res (1989) 1.51
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J Neurosci (2009) 1.44
Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Proc Natl Acad Sci U S A (2008) 1.41
Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.36
Muscle denervation increases the levels of two mRNAs coding for the acetylcholine receptor alpha-subunit. J Neurosci (1985) 1.35
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J Neurosci (2006) 1.33
Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO Rep (2008) 1.33
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Mol Cell Neurosci (2008) 1.22
The ubiquitin-proteasome pathway in health and disease of the nervous system. Trends Neurosci (2007) 1.09
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genet (2009) 0.95
Axonal transport of two major components of the ubiquitin system: free ubiquitin and ubiquitin carboxyl-terminal hydrolase PGP 9.5. Brain Res (1991) 0.87
Changes in ubiquitin immunoreactivity in developing rat brain: a putative role for ubiquitin and ubiquitin conjugates in dendrite outgrowth and differentiation. Neuroscience (1997) 0.80
Changes in three types of ubiquitin mRNA and ubiquitin-protein conjugate levels during lens development. Exp Eye Res (2002) 0.78
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol (2006) 4.25
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06
A ubiquitin stress response induces altered proteasome composition. Cell (2007) 3.82
Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol (2005) 3.38
Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol (2002) 3.34
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell (2006) 2.87
Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem (2004) 2.85
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci U S A (2002) 2.72
PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLoS Biol (2008) 2.58
Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc Natl Acad Sci U S A (2005) 2.50
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol (2003) 2.29
STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol (2008) 2.29
Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome. Mol Cell (2010) 2.13
Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci (2003) 2.08
Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export. EMBO J (2002) 2.07
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci U S A (2007) 2.03
Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol (2007) 2.02
Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem (2005) 2.01
Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature (2009) 1.97
Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci (2006) 1.96
Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem (2007) 1.93
Characterization of the proteasome using native gel electrophoresis. Methods Enzymol (2005) 1.89
Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nat Struct Mol Biol (2007) 1.89
A proteasome for all occasions. FEBS Lett (2007) 1.84
Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res (2004) 1.81
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78
Localization to the proteasome is sufficient for degradation. J Biol Chem (2004) 1.72
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem (2005) 1.71
The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci (2005) 1.69
Chemokines: integrators of pain and inflammation. Nat Rev Drug Discov (2005) 1.68
Abnormalities in hippocampal functioning with persistent pain. J Neurosci (2012) 1.68
Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 1.61
The chemokine stromal cell-derived factor-1 regulates GABAergic inputs to neural progenitors in the postnatal dentate gyrus. J Neurosci (2008) 1.59
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J Neurosci (2009) 1.59
Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem (2004) 1.58
Role of adult hippocampal neurogenesis in persistent pain. Pain (2016) 1.56
CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav Immun (2007) 1.53
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury. J Neuroinflammation (2011) 1.50
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol Biol (2005) 1.48
Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47
CXCR4 signaling in the regulation of stem cell migration and development. J Neuroimmunol (2008) 1.47
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol (2012) 1.46
Proteasome disassembly and downregulation is correlated with viability during stationary phase. Curr Biol (2003) 1.44
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J Neurosci (2009) 1.44
An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol (2011) 1.36
CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A (2012) 1.34
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep (2009) 1.34
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J Neurosci (2006) 1.33
The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells (2011) 1.32
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol Cell (2010) 1.29
Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem (2005) 1.26
Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy. Mol Pain (2009) 1.22
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1alpha and the HIV-1 coat protein gp120: a fluorescence resonance energy transfer (FRET) study. J Pharmacol Exp Ther (2004) 1.21
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A (2003) 1.18
Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1. Proc Natl Acad Sci U S A (2009) 1.16
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res (2010) 1.15
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci (2009) 1.13
Regulation of calcium currents by chemokines and their receptors. J Neuroimmunol (2002) 1.12
Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. J Neurosci (2013) 1.10
Activation of the nuclear factor of activated T-cells (NFAT) mediates upregulation of CCR2 chemokine receptors in dorsal root ganglion (DRG) neurons: a possible mechanism for activity-dependent transcription in DRG neurons in association with neuropathic pain. Mol Cell Neurosci (2007) 1.10
Integrin/Chemokine receptor interactions in the pathogenesis of experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol (2014) 1.10
Distinctive properties of CXC chemokine receptor 4-expressing Cajal-Retzius cells versus GABAergic interneurons of the postnatal hippocampus. J Physiol (2010) 1.08
Chemokine signaling and the management of neuropathic pain. Mol Interv (2009) 1.07
Role of a ubiquitin-like modification in polarized morphogenesis. Science (2002) 1.06
CXCR4 signaling mediates morphine-induced tactile hyperalgesia. Brain Behav Immun (2010) 1.05
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response. J Biol Chem (2011) 1.04
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number. J Physiol (2013) 1.04
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Metabolism (2003) 1.02
Comparison of postoperative pain in patients receiving interscalene block or general anesthesia for shoulder surgery. Orthopedics (2002) 1.02
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem (2011) 1.01
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest (2014) 1.00
Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death. Mol Neurodegener (2014) 1.00
The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter. Neurobiol Dis (2011) 1.00