Published in J Allergy Clin Immunol on July 01, 2003
Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA (2008) 6.24
A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol (2007) 1.71
Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database Syst Rev (2010) 1.52
Retracted Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all? Naunyn Schmiedebergs Arch Pharmacol (2008) 1.12
Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in healthy volunteers via pMDI alone and spacer. Br J Clin Pharmacol (2010) 1.05
Molecular networks in drug discovery. Crit Rev Biomed Eng (2010) 0.98
Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol (2007) 0.88
Extraneuronal monoamine transporter mediates the permissive action of cortisol in the Guinea pig trachea: possible involvement of tracheal chondrocytes. PLoS One (2013) 0.82
Potential mechanisms to explain how LABAs and PDE4 inhibitors enhance the clinical efficacy of glucocorticoids in inflammatory lung diseases. F1000Prime Rep (2015) 0.81
Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers. J Allergy Clin Immunol (2004) 0.80
Seretide meta-analysis missed important features and overstates any advantages over concurrent LABA/ICS devices. J Allergy Clin Immunol (2004) 0.79
Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols. Eur J Pharm Sci (2011) 0.78
The long-acting β2 -adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent manner. Br J Pharmacol (2015) 0.77
Positioning new pharmacotherapies for COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.77
Comparison and optimal use of fixed combinations in the management of COPD. Int J Chron Obstruct Pulmon Dis (2007) 0.76
Current trends in the treatment of asthma: focus on the simultaneous administration of salmeterol/fluticasone. J Asthma Allergy (2010) 0.75
The History of Therapeutic Aerosols: A Chronological Review. J Aerosol Med Pulm Drug Deliv (2016) 0.75
Asthma control in Canada remains suboptimal: the Reality of Asthma Control (TRAC) study. Can Respir J (2006) 3.27
Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Am J Respir Crit Care Med (2010) 2.85
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.06
Minimal clinically important differences in pharmacological trials. Am J Respir Crit Care Med (2014) 2.00
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am J Respir Crit Care Med (2006) 1.86
A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environ Health Perspect (2009) 1.77
Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids. Ann Intern Med (2006) 1.71
Nontuberculous mycobacterial infection as a cause of difficult-to-control asthma: a case-control study. Chest (2010) 1.49
The Ontario Asthma Regional Variation Study: emergency department visit rates and the relation to hospitalization rates. Chest (2006) 1.38
Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells. Immunology (2008) 1.38
Asthma control in Canada: no improvement since we last looked in 1999. Can Fam Physician (2007) 1.24
Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: the ENLIGHTEN study. Respir Med (2013) 1.19
Synthetic responses in airway smooth muscle. J Allergy Clin Immunol (2004) 1.09
What do we know about asthma triggers? a review of the literature. J Asthma (2012) 1.06
Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol (2011) 1.06
Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the need for longitudinal observational studies in COPD. COPD (2012) 1.04
Interaction of C/EBPalpha and the glucocorticoid receptor in vivo and in nontransformed human cells. FASEB J (2002) 1.03
Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem (2007) 0.97
Variations and gaps in management of acute asthma in Ontario emergency departments. Chest (2008) 0.97
The coming of age of asthma guidelines. Lancet (2008) 0.96
TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure. Hum Immunol (2010) 0.95
Assessment of a medication-based asthma index for population research. Am J Respir Crit Care Med (2002) 0.95
β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc Natl Acad Sci U S A (2011) 0.94
Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke. J Mol Med (Berl) (2008) 0.93
Comparative efficacy of indacaterol in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2012) 0.89
Diffuse panbronchiolitis in a Caucasian man in Canada. Can Respir J (2003) 0.89
Bronchodilator responsiveness and reported respiratory symptoms in an adult population. PLoS One (2013) 0.89
Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients. PLoS One (2012) 0.88
A perioperative smoking cessation intervention with varenicline: a double-blind, randomized, placebo-controlled trial. Anesthesiology (2012) 0.88
Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages. Eur J Pharmacol (2007) 0.88
IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids. Pulm Pharmacol Ther (2005) 0.88
Profile of eicosanoids in breath condensate in asthma and COPD. J Breath Res (2012) 0.87
Effect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthma. Chest (2003) 0.86
Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle. Pulm Pharmacol Ther (2007) 0.86
Prospects for antihistamines in the treatment of asthma. J Allergy Clin Immunol (2003) 0.86
Downregulation by a long-acting beta2-adrenergic receptor agonist and corticosteroid of Staphylococcus aureus-induced airway epithelial inflammatory mediator production. Am J Physiol Lung Cell Mol Physiol (2006) 0.86
Women and asthma: lessons from a gender analysis of the asthma in Canada survey. J Asthma (2006) 0.85
Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells. J Pharmacol Exp Ther (2013) 0.85
Neutrophil adhesion molecules in experimental rhinovirus infection in COPD. Respir Res (2013) 0.84
Types, frequency and impact of asthma triggers on patients' lives: a quantitative study in five European countries. J Asthma (2013) 0.84
Hot tub lung mimicking classic acute and chronic hypersensitivity pneumonitis: two case reports. Can Respir J (2007) 0.84
Omalizumab for asthma: pharmacology and clinical profile. Expert Rev Respir Med (2009) 0.84
Influence of current or former smoking on asthma management and control. Can Respir J (2008) 0.83
Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome? Treat Respir Med (2005) 0.83
What do patients expect from their first visit to a pain clinic? Clin J Pain (2005) 0.83
Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor. Eur Respir J (2012) 0.83
The value of early diagnosis for effective management of chronic obstructive pulmonary disease. J Fam Pract (2007) 0.82
The effect of montelukast on exhaled nitric oxide of alveolar and bronchial origin in inhaled corticosteroid-treated asthma. Respir Med (2008) 0.82
Economic issues in the use of office spirometry for lung health assessment. Can Respir J (2003) 0.82
Alpha-1 antitrypsin deficiency: a commonly overlooked cause of lung disease. CMAJ (2012) 0.82
Inhaled long-acting β2 agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD. J Allergy Clin Immunol (2013) 0.82
Dynamic airway evaluation with volume CT: initial experience. Can Assoc Radiol J (2010) 0.82
Evaluation of a questionnaire to assess compliance with anti-asthma medications. J Asthma (2004) 0.81
Effect of nasal triamcinolone acetonide on lower airway inflammatory markers in patients with allergic rhinitis. J Allergy Clin Immunol (2003) 0.81
Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. J Allergy Clin Immunol (2003) 0.80
Parent-reported symptoms may not be adequate to define asthma control in children. Pediatr Pulmonol (2007) 0.80
Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells. Cell Immunol (2011) 0.80
Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein. J Allergy Clin Immunol (2005) 0.80
Tiotropium and simplified detection of dynamic hyperinflation. Chest (2007) 0.79
Infection with Mycoplasma pneumoniae is not related to asthma control, asthma severity, and location of airway obstruction. Int J Gen Med (2010) 0.79
Mortality among subjects with chronic obstructive pulmonary disease or asthma at two respiratory disease clinics in Ontario. Can Respir J (2011) 0.78
Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study. BMC Clin Pharmacol (2010) 0.78
Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils. Pulm Pharmacol Ther (2004) 0.78
Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol (2003) 0.77
Low-dose fluticasone propionate with and without salmeterol in steroid-naïve patients with mild, uncontrolled asthma. Respir Med (2009) 0.76
Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease. Curr Pharm Des (2004) 0.76
SMART isn't. J Allergy Clin Immunol (2010) 0.76
New and controversial therapies for chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 0.76
Response to: 'what should we tell medical students and residents about euthanasia and assisted suicide?'. Aust N Z J Psychiatry (2013) 0.75
Long acting beta2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant. Respir Res (2010) 0.75
Predicting the need for supplemental oxygen during airline flight in patients with chronic pulmonary disease: a comparison of predictive equations and altitude simulation. Can Respir J (2009) 0.75
A step forward in COPD management: reading between the lines. Chest (2012) 0.75
A Randomized Controlled Trial to Determine the Effect of Inhaled Corticosteroid on Intraocular Pressure in Open-Angle Glaucoma and Ocular Hypertension: The ICOUGH Study. J Glaucoma (2017) 0.75
End-of-life care in nursing and care homes. Nurs Times (2013) 0.75
Alpha-1 antitrypsin deficiency in Canada: regional disparities in diagnosis and management. COPD (2015) 0.75
Seretide: a pharmacoeconomic analysis. J Med Econ (2008) 0.75
Why do older people oppose physician-assisted dying? A qualitative study. Palliat Med (2013) 0.75
Intranasal fluticasone propionate inhibits allergen induced bone marrow eosinophilia in mice. Pulm Pharmacol Ther (2002) 0.75
Asthma controller delay and recurrence risk after an emergency department visit or hospitalization. Respir Med (2012) 0.75
Airway identification within planar gamma camera images using computer models of lung morphology. Pharm Res (2005) 0.75
Factors to consider when selecting a nebulizer for a new inhaled drug product development program. Expert Opin Drug Deliv (2015) 0.75