Published in J Mol Med (Berl) on July 04, 2008
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci (2011) 1.08
Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respir Res (2009) 1.01
Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells. PLoS One (2014) 1.01
Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease. PLoS One (2012) 0.90
Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation. J Immunol (2012) 0.87
Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in COPD. Respir Res (2011) 0.81
Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis. J Inflamm (Lond) (2015) 0.80
Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update. Br J Pharmacol (2016) 0.77
Formoterol is more effective than salmeterol in suppressing neutrophil reactivity. ERJ Open Res (2015) 0.75
Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1. PLoS One (2016) 0.75
Co-inhalation of roflumilast, rather than formoterol, with fluticasone more effectively improves asthma in asthmatic mice. Exp Biol Med (Maywood) (2017) 0.75
Effect of Phospholipid Transfer Protein on Cigarette Smoke Extract-Induced IL-8 Production in Human Pulmonary Epithelial Cells. Inflammation (2016) 0.75
Gene regulation by steroid hormones. Cell (1989) 12.96
Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet (1985) 10.62
Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (1986) 7.81
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell (1990) 6.84
Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell (1990) 6.56
Functional domains of the human glucocorticoid receptor. Cell (1986) 4.68
Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci (1993) 3.80
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev (2000) 3.71
Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys (1993) 3.48
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev (2007) 3.03
Chemokines in pathology and medicine. J Intern Med (2001) 2.83
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol (2006) 2.66
Exacerbations of chronic obstructive pulmonary disease. Eur Respir J (2007) 2.65
Chronic obstructive pulmonary disease. Lancet (2003) 2.64
Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.59
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J (1994) 2.58
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol (2002) 2.46
The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem (1993) 2.42
The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem (1996) 2.13
Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am J Respir Crit Care Med (1997) 2.12
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol (2002) 2.10
Characterization of two high affinity human interleukin-8 receptors. J Biol Chem (1992) 2.09
Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation. Blood (1991) 2.05
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res (2006) 1.89
Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J (2002) 1.79
Corticosteroid effects on cell signalling. Eur Respir J (2006) 1.63
Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol (2000) 1.54
Inhaled salmeterol and fluticasone: a study comparing monotherapy and combination therapy in asthma. Ann Allergy Asthma Immunol (1999) 1.46
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation. J Biol Chem (1997) 1.43
Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial. Thorax (2007) 1.42
The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med (2002) 1.38
MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. Respir Res (2005) 1.37
The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. Mol Med (1996) 1.35
Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res (2007) 1.31
Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med (1999) 1.30
Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. Thorax (2002) 1.26
Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res (2006) 1.20
Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir Res (2007) 1.16
Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Pathol (1998) 1.11
The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes. Mol Endocrinol (2004) 1.11
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice. Eur Respir J (2006) 1.02
Light cigarette smoke-induced emphysema and NFkappaB activation in mouse lung. Int J Exp Pathol (2006) 0.96
Cigarette smoke stimulates the production of chemokines in mast cells. J Leukoc Biol (2007) 0.92
Effects of salmeterol on cilia and mucus in COPD and pneumonia patients. Pharmacol Res (2005) 0.92
Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages. Eur J Pharmacol (2007) 0.88
Interactions of glucocorticoids and beta 2-agonists. Eur Respir J (1996) 0.87
Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle. Pulm Pharmacol Ther (2007) 0.86
Stress and hypothermia in mice in a nose-only cigarette smoke exposure system. Inhal Toxicol (2006) 0.85
Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines. Biochem Pharmacol (2005) 0.85
Chronic obstructive pulmonary disease: role of matrix metalloproteases and future challenges of drug therapy. Expert Opin Investig Drugs (2007) 0.83
Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells. Cancer Res (2003) 0.82
Tissue-specific suppression of estrogen, androgen and glucocorticoid receptor gene expression in feral vitellogenic male Mozambique tilapia. Chemosphere (2007) 0.80
[The pathobiology of COPD]. Wien Med Wochenschr (2005) 0.76
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med (2006) 5.05
Nitric oxide in health and disease of the respiratory system. Physiol Rev (2004) 3.15
Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Chem Biol Interact (2013) 3.10
Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Am J Respir Crit Care Med (2010) 2.85
Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers. J Allergy Clin Immunol (2003) 2.43
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.06
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am J Respir Crit Care Med (2006) 1.86
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med (2002) 1.73
An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.51
Reactive nitrogen species in the respiratory tract. Eur J Pharmacol (2006) 1.50
Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells. Immunology (2008) 1.38
Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respir Res (2010) 1.27
Induction of lung emphysema is prevented by L-arginine-threonine-arginine. FASEB J (2008) 1.27
Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res (2006) 1.20
Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. Am J Physiol Lung Cell Mol Physiol (2010) 1.15
Pathogenesis and pharmacotherapy of Hidradenitis suppurativa. Eur J Pharmacol (2011) 1.14
Targeting chemokine receptors in chronic inflammatory diseases: an extensive review. Pharmacol Ther (2011) 1.13
Synthetic responses in airway smooth muscle. J Allergy Clin Immunol (2004) 1.09
Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Respir Res (2006) 1.07
Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol (2011) 1.06
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors. J Leukoc Biol (2013) 1.05
Cells, mediators and Toll-like receptors in COPD. Eur J Pharmacol (2008) 1.04
Mediators of asthma: nitric oxide. Pulm Pharmacol Ther (2002) 1.04
Elicitation of allergic asthma by immunoglobulin free light chains. Proc Natl Acad Sci U S A (2005) 1.03
Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. J Inflamm (Lond) (2009) 1.03
Interaction of C/EBPalpha and the glucocorticoid receptor in vivo and in nontransformed human cells. FASEB J (2002) 1.03
Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut (2013) 1.02
Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease. Pharmacol Rev (2012) 1.02
Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respir Res (2009) 1.01
N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. Eur J Pharmacol (2011) 1.01
Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Food Chem Toxicol (2013) 1.00
Mechanisms of allergy and asthma. Eur J Pharmacol (2008) 1.00
Glutathione and other low-molecular-weight thiols relax guinea pig trachea ex vivo: interactions with nitric oxide? Am J Physiol Lung Cell Mol Physiol (2002) 1.00
Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem (2007) 0.97
Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation? PLoS One (2013) 0.97
TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure. Hum Immunol (2010) 0.95
ATP in the pathogenesis of lung emphysema. Eur J Pharmacol (2009) 0.95
Immunoglobulin free light chains and mast cells: pivotal role in T-cell-mediated immune reactions? Trends Immunol (2003) 0.94
Mast cells and nerves tickle in the tummy: implications for inflammatory bowel disease and irritable bowel syndrome. Pharmacol Ther (2007) 0.94
Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. J Mass Spectrom (2002) 0.94
β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc Natl Acad Sci U S A (2011) 0.94
ATP and the pathogenesis of COPD. Eur J Pharmacol (2010) 0.93
Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases. J Immunol (2010) 0.93
Cigarette smoke stimulates the production of chemokines in mast cells. J Leukoc Biol (2007) 0.92
Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor. J Immunol (2003) 0.92
Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res (2014) 0.91
Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation. PLoS One (2009) 0.91
CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. Eur J Pharmacol (2011) 0.91
Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol Sci (2008) 0.90
Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice. Respir Res (2007) 0.90
Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicol In Vitro (2013) 0.90
Open letter to the European Commission: scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles. Arch Toxicol (2013) 0.89
Mast cell-derived TNF-alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction. J Immunol (2002) 0.89
Key role for mast cells in nonatopic asthma. J Immunol (2002) 0.88
Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages. Eur J Pharmacol (2007) 0.88
Immunoglobulin-free light chains mediate antigen-specific responses of murine dorsal root ganglion neurons. J Neuroimmunol (2009) 0.88
Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients. PLoS One (2012) 0.88
Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets. Eur J Pharmacol (2008) 0.88
IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids. Pulm Pharmacol Ther (2005) 0.88
Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease. Curr Drug Targets (2006) 0.87
Downregulation by a long-acting beta2-adrenergic receptor agonist and corticosteroid of Staphylococcus aureus-induced airway epithelial inflammatory mediator production. Am J Physiol Lung Cell Mol Physiol (2006) 0.86
Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction. J Immunol (2006) 0.86
The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2. Eur J Pharmacol (2010) 0.86
Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.86
Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle. Pulm Pharmacol Ther (2007) 0.86
Ramp-ing up allergies: Nramp1 (Slc11a1), macrophages and the hygiene hypothesis. Trends Immunol (2004) 0.85
Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines. Biochem Pharmacol (2005) 0.85
Mast cell activation is differentially affected by heat shock. Exp Hematol (2005) 0.85
Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells. J Pharmacol Exp Ther (2013) 0.85
Neutrophil adhesion molecules in experimental rhinovirus infection in COPD. Respir Res (2013) 0.84
TNF-alpha is crucial for the development of mast cell-dependent colitis in mice. Am J Physiol Gastrointest Liver Physiol (2006) 0.84
Subunits of IgM reconstitute defective contact sensitivity in B-1 cell-deficient xid mice: kappa light chains recruit T cells independent of complement. J Immunol (2002) 0.84
TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma. J Pharmacol Exp Ther (2005) 0.84
What do patients expect from their first visit to a pain clinic? Clin J Pain (2005) 0.83
Dendritic cells in pathogenesis of COPD. Curr Pharm Des (2012) 0.83
Trimellitic anhydride-conjugated serum albumin activates rat alveolar macrophages in vitro. J Occup Med Toxicol (2006) 0.83
The guinea pig as an animal model for asthma. Curr Drug Targets (2008) 0.83