Published in Curr Drug Targets CNS Neurol Disord on August 01, 2003
Chloride channels as drug targets. Nat Rev Drug Discov (2008) 3.22
Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther (2008) 1.02
Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther (2007) 1.00
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem (2011) 0.99
Influence of 17beta-estradiol and progesterone on GABAergic gene expression in the arcuate nucleus, amygdala and hippocampus of the rhesus macaque. Brain Res (2009) 0.88
Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships. Cell Mol Neurobiol (2004) 0.87
Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Mol Pharmacol (2010) 0.84
Neurovascular interaction and the pathophysiology of diabetic retinopathy. Exp Diabetes Res (2011) 0.83
Random assembly of GABA rho1 and rho2 subunits in the formation of heteromeric GABA(C) receptors. Cell Mol Neurobiol (2006) 0.82
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. PLoS One (2015) 0.82
Resveratrol Inhibits GABAC ρ Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes. Korean J Physiol Pharmacol (2013) 0.81
Mechanism of Allosteric Modulation of the Cys-loop Receptors. Pharmaceuticals (Basel) (2010) 0.76
Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology (Berl) (2013) 0.76
Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents. Korean J Physiol Pharmacol (2013) 0.75
GABA-ρ receptors: distinctive functions and molecular pharmacology. Br J Pharmacol (2017) 0.75
Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. J Ophthalmol (2016) 0.75
Optogenetic Stimulation of Prefrontal Glutamatergic Neurons Enhances Recognition Memory. J Neurosci (2016) 0.75
Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA/C receptors. Biochem Biophys Res Commun (2016) 0.75
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors. Bioorg Med Chem (2005) 3.38
Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol (2009) 1.11
Flavonoid modulation of GABA(A) receptors. Br J Pharmacol (2011) 1.09
Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorg Med Chem (2009) 1.07
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. Br J Pharmacol (2011) 1.07
The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem (2007) 1.03
Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther (2008) 1.02
Modulation of ionotropic GABA receptors by natural products of plant origin. Adv Pharmacol (2006) 1.00
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A (2012) 0.99
The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol (2004) 0.97
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. Eur J Pharmacol (2003) 0.96
A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chem Biol Drug Des (2008) 0.95
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem (2011) 0.91
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J Biol Chem (2004) 0.91
Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology (2008) 0.90
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem (2008) 0.88
Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review. Amino Acids (2013) 0.87
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol (2004) 0.87
Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. J Ethnopharmacol (2009) 0.86
Guanidino acids act as rho1 GABA(C) receptor antagonists. Neurochem Res (2009) 0.86
Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochem Pharmacol (2012) 0.86
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochem Pharmacol (2011) 0.86
Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorg Med Chem Lett (2012) 0.85
Double-Mannich annulation of cyclic ketones using N,N-Bis(ethoxymethyl)alkylamine reagents. Org Lett (2006) 0.85
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J Med Chem (2009) 0.84
(3-Aminocyclopentyl)methylphosphinic acids: novel GABA(C) receptor antagonists. Neuropharmacology (2006) 0.84
Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. Neuropharmacology (2004) 0.83
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorg Med Chem Lett (2007) 0.83
γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. J Neurochem (2010) 0.83
6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. Eur J Pharmacol (2005) 0.83
Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. Br J Pharmacol (2012) 0.82
Medicinal chemistry of ρ GABAC receptors. Future Med Chem (2011) 0.82
2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol (2012) 0.82
Factors influencing pharmacy services in opioid substitution treatment. Drug Alcohol Rev (2013) 0.82
Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem (2003) 0.82
Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. Eur J Pharmacol (2007) 0.82
Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors. ACS Chem Neurosci (2012) 0.81
Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett (2003) 0.81
The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochem Res (2009) 0.81
Stabilization of zwitterions in solution: GABA analogues. J Phys Chem A (2005) 0.81
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. J Med Chem (2009) 0.80
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int (2003) 0.80
Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. J Biol Chem (2013) 0.80
Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia. Curr Med Chem (2015) 0.80
Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res (2010) 0.80
Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. J Ethnopharmacol (2013) 0.80
Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci (2015) 0.79
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol (2004) 0.79
Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chem Commun (Camb) (2012) 0.79
ρ1 GABAC receptors are expressed in fibrous and cartilaginous layers of chick sclera and located on sclera fibroblasts and chondrocytes. J Neurochem (2011) 0.79
2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. Mol Pharmacol (2011) 0.79
Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Org Biomol Chem (2006) 0.79
The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor. Chem Commun (Camb) (2011) 0.78
trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. Br J Pharmacol (2002) 0.78
Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chem Commun (Camb) (2011) 0.78
Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain. J Neuroimmune Pharmacol (2015) 0.78
Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. ACS Chem Neurosci (2010) 0.78
Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor. ACS Chem Neurosci (2012) 0.78
Convulsant actions of calycanthine. Toxicol Appl Pharmacol (2003) 0.77
Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). Org Biomol Chem (2010) 0.77
Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes. Virology (2011) 0.76
Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. J Med Chem (2013) 0.76
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorg Med Chem (2005) 0.76
Identification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA(A) receptors. ChemMedChem (2011) 0.76
Identification of GABA receptors in chick cornea. Mol Vis (2012) 0.76
Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochem Res (2013) 0.75
Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues. J Phys Chem A (2005) 0.75
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology (2012) 0.75