Published in Development on September 01, 2003
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature (2009) 3.88
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71
Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64
Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci U S A (2009) 2.56
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell (2008) 2.46
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A (2007) 2.15
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2005) 1.85
Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest (2008) 1.80
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood (2009) 1.51
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood (2006) 1.48
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell (2012) 1.43
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood (2005) 1.39
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol (2013) 1.38
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J (2012) 1.37
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood (2005) 1.37
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Directed differentiation of mouse embryonic stem cells into thyroid follicular cells. Endocrinology (2006) 1.35
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30
Hematopoietic development from human induced pluripotent stem cells. Ann N Y Acad Sci (2009) 1.22
Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood (2007) 1.21
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21
Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development (2014) 1.20
Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol (2008) 1.19
Early cardiac development: a view from stem cells to embryos. Cardiovasc Res (2012) 1.18
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (2010) 1.17
Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code. Blood (2008) 1.16
Resident vascular progenitor cells--diverse origins, phenotype, and function. J Cardiovasc Transl Res (2010) 1.15
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A (2012) 1.14
ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood (2012) 1.14
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. Blood (2009) 1.13
HoxA3 is an apical regulator of haemogenic endothelium. Nat Cell Biol (2010) 1.13
Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One (2009) 1.11
Hemogenic endothelium during development and beyond. Blood (2012) 1.11
Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol Cell Biol (2005) 1.09
Smad1 expands the hemangioblast population within a limited developmental window. Blood (2006) 1.05
Development of the endocardium. Pediatr Cardiol (2010) 1.04
Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Circulation (2007) 1.04
DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PLoS One (2012) 1.04
Transcriptional regulation of endothelial cell and vascular development. Circ Res (2013) 1.03
USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription. PLoS Genet (2013) 1.03
Cardiac regeneration using human embryonic stem cells: producing cells for future therapy. Regen Med (2010) 1.03
Molecular and developmental biology of the hemangioblast. Dev Dyn (2008) 0.99
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
Systematic engineering of 3D pluripotent stem cell niches to guide blood development. Biomaterials (2011) 0.97
The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis. Mol Cell Biol (2009) 0.97
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. Dev Cell (2016) 0.96
ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol (2011) 0.95
Fibronectin mediates mesendodermal cell fate decisions. Development (2013) 0.95
Chamber identity programs drive early functional partitioning of the heart. Nat Commun (2015) 0.94
A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity. Genome Res (2008) 0.94
Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells. Stem Cell Reports (2014) 0.93
PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. J Mol Cell Cardiol (2007) 0.92
Development of embryonic stem cells in recombinant kidneys. Organogenesis (2012) 0.92
Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells. Cell Cycle (2013) 0.92
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nat Cell Biol (2015) 0.91
Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. Stem Cells Dev (2014) 0.89
Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides. J Biol Chem (2010) 0.88
Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome. Sci Rep (2016) 0.87
Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression. Circulation (2009) 0.87
Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells. BMC Biol (2014) 0.87
Differentiation of murine embryonic stem cells induces progesterone receptor gene expression. Exp Cell Res (2005) 0.87
A microparticle approach to morphogen delivery within pluripotent stem cell aggregates. Biomaterials (2013) 0.86
Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J (2015) 0.86
Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2. Mech Dev (2009) 0.86
MiR-24 is required for hematopoietic differentiation of mouse embryonic stem cells. PLoS Genet (2015) 0.86
An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. Biol Open (2014) 0.86
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development. PLoS One (2012) 0.85
Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. Stem Cell Res Ther (2013) 0.85
Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis. J Cell Sci (2007) 0.85
Plasticity and maintenance of hematopoietic stem cells during development. Recent Pat Biotechnol (2011) 0.85
Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies. Tissue Eng Part A (2014) 0.84
Human embryonic stem cells hemangioblast express HLA-antigens. J Transl Med (2009) 0.84
Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling. Cell Mol Life Sci (2007) 0.84
Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation. PLoS One (2013) 0.84
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood (2010) 0.84
Assessing the bipotency of in vitro-derived neuromesodermal progenitors. F1000Res (2015) 0.83
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol (2010) 0.83
Embryonic Stem Cells as a Model for Cardiac Development and Disease. Drug Discov Today Dis Models (2008) 0.83
Quantum dots do not affect the behaviour of mouse embryonic stem cells and kidney stem cells and are suitable for short-term tracking. PLoS One (2012) 0.83
An expandable, inducible hemangioblast state regulated by fibroblast growth factor. Stem Cell Reports (2014) 0.83
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells (2014) 0.83
Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells (2010) 0.82
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS One (2012) 0.82
Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro. J Vis Exp (2015) 0.82
Endothelial cells from embryonic stem cells in a chemically defined medium. Stem Cells Dev (2011) 0.82
Induction of hematopoietic differentiation of mouse embryonic stem cells by an AGM-derived stromal cell line is not further enhanced by overexpression of HOXB4. Stem Cells Dev (2010) 0.81
Activin A promotes hematopoietic fated mesoderm development through upregulation of brachyury in human embryonic stem cells. Stem Cells Dev (2012) 0.81
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell (2008) 10.34
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature (2008) 10.27
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell (2011) 6.71
Development of definitive endoderm from embryonic stem cells in culture. Development (2004) 4.61
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res (2007) 4.41
Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature (2004) 4.20
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature (2009) 3.88
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71
Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol (2006) 3.02
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat Biotechnol (2011) 2.84
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81
Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nat Biotechnol (2007) 2.75
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A (2007) 2.15
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods (2013) 2.14
Fiber-optical analog of the event horizon. Science (2008) 2.08
Radiologic measurements of tumor response to treatment: practical approaches and limitations. Radiographics (2008) 2.08
T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.99
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2005) 1.85
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells (2010) 1.75
Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood (2002) 1.72
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol (2011) 1.70
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood (2010) 1.66
Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells. J Neurosurg (2007) 1.63
In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas. Neuro Oncol (2008) 1.62
Validation study of radio-guided sentinel lymph node navigation in esophageal cancer. Ann Surg (2009) 1.62
The important role of operations in the management of anaplastic thyroid carcinoma. Surgery (2002) 1.61
The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. Development (2008) 1.54
Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo. Cell Cycle (2007) 1.54
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol (2008) 1.54
Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis (2009) 1.51
Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. J Am Soc Nephrol (2007) 1.50
Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells. Cardiovasc Res (2012) 1.47
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J Gen Physiol (2013) 1.44
Collaboration strategies in nontraditional community-based participatory research partnerships: lessons from an academic−community partnership with autistic self-advocates. Prog Community Health Partnersh (2011) 1.43
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev (2007) 1.43
Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice. Proc Natl Acad Sci U S A (2002) 1.41
Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development (2004) 1.41
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood (2005) 1.39
Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med (2003) 1.38
Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol (2013) 1.38
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J (2012) 1.37
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood (2005) 1.37
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Site-specific integration of adeno-associated virus involves partial duplication of the target locus. Proc Natl Acad Sci U S A (2009) 1.35
The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype. Blood (2006) 1.35
Directed differentiation of mouse embryonic stem cells into thyroid follicular cells. Endocrinology (2006) 1.35
Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One (2011) 1.34
The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol (2013) 1.28
Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology (2003) 1.25
Retinoic acid signaling is essential for embryonic hematopoietic stem cell development. Cell (2013) 1.25
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol Rep (2010) 1.24
Stereotactic body radiotherapy for primary lung cancer at a dose of 50 Gy total in five fractions to the periphery of the planning target volume calculated using a superposition algorithm. Int J Radiat Oncol Biol Phys (2008) 1.23
Committing embryonic stem cells to early endocrine pancreas in vitro. Stem Cells (2004) 1.23
Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development (2013) 1.23
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21
Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol (2008) 1.19
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics (2007) 1.19
Dose distribution analysis of axillary lymph nodes for three-dimensional conformal radiotherapy with a field-in-field technique for breast cancer. Int J Radiat Oncol Biol Phys (2008) 1.18
Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification. Blood (2009) 1.17
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code. Blood (2008) 1.16
Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction. Magn Reson Med (2008) 1.14
Origin of blood cells and HSC production in the embryo. Trends Immunol (2012) 1.14
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. Blood (2009) 1.13
Deformation of (Mg,Fe)SiO3 post-perovskite and D'' anisotropy. Science (2007) 1.13
Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine. Semin Cell Dev Biol (2012) 1.12
Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest (2013) 1.11
The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis. Blood (2009) 1.11
Defining the path to hematopoietic stem cells. Nat Biotechnol (2013) 1.11