Published in J Biol Chem on July 21, 2003
Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66
Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biol Chem (2003) 2.12
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85
Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res (2005) 1.39
Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies. Mol Cancer Ther (2008) 1.38
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest (2013) 1.37
Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells. Cancer Res (2006) 1.36
The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity. Cell Death Dis (2010) 1.11
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. J Cell Biol (2012) 1.10
Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression. Oncogene (2008) 1.08
Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Oncogene (2008) 1.00
Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci (2007) 0.98
Role of Radiation-induced TGF-beta Signaling in Cancer Therapy. Mol Cell Pharmacol (2009) 0.95
Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. Cancer Res (2010) 0.90
Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells. PLoS One (2013) 0.89
TGF-β inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II. Mol Endocrinol (2010) 0.87
Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis. Am J Physiol Endocrinol Metab (2013) 0.85
The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. J Biol Chem (2006) 0.83
Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice. Stem Cells Dev (2014) 0.83
MicroRNAs overexpressed in growth-restricted rat skeletal muscles regulate the glucose transport in cell culture targeting central TGF-β factor SMAD4. PLoS One (2012) 0.82
Role of IL-10 in the progression of kidney disease. World J Transplant (2013) 0.82
Inhibition of apelin expression switches endothelial cells from proliferative to mature state in pathological retinal angiogenesis. Angiogenesis (2013) 0.82
Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin. Mol Cancer Res (2012) 0.81
PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis. Cell Death Dis (2013) 0.78
Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway. Cancer Lett (2006) 0.76
TGF-β and stem cell factor regulate cell proliferation in the proximal stem cell niche. Prostate (2011) 0.75
Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling. J Signal Transduct (2015) 0.75
Adipose-derived stem cells enhance myogenic differentiation in the mdx mouse model of muscular dystrophy via paracrine signaling. Neural Regen Res (2016) 0.75
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells. Stem Cell Res Ther (2016) 0.75
Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro. Sci Rep (2016) 0.75
Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol (2006) 6.07
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell (2009) 3.40
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59
TGF-β upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest (2012) 2.44
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res (2008) 2.19
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res (2006) 2.01
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85
Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res (2002) 1.69
Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell (2005) 1.65
A prototype for unsupervised analysis of tissue microarrays for cancer research and diagnostics. IEEE Trans Inf Technol Biomed (2004) 1.55
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest (2009) 1.50
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem (2004) 1.46
Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis. Mol Cancer (2010) 1.45
Breast cancer prognosis by combinatorial analysis of gene expression data. Breast Cancer Res (2006) 1.43
TGFBR1*6A and cancer: a meta-analysis of 12 case-control studies. J Clin Oncol (2004) 1.42
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat (2008) 1.41
The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3. J Biol Chem (2001) 1.40
ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval, high-performance computing, and grid technology. J Am Med Inform Assoc (2011) 1.40
Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies. Mol Cancer Ther (2008) 1.38
Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer. Biochem Pharmacol (2006) 1.37
Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. Cancer J (2003) 1.35
Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res (2004) 1.29
Ovarian cancer detection by logical analysis of proteomic data. Proteomics (2004) 1.28
Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes. Endocrinology (2006) 1.18
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J (2003) 1.16
Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. J Biol Chem (2004) 1.15
Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res (2008) 1.14
Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. J Biol Chem (2004) 1.14
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood (2012) 1.10
Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells. Cancer Res (2009) 1.08
Unsupervised imaging, registration and archiving of tissue microarrays. Proc AMIA Symp (2002) 1.05
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors from transgenic mice. Oncogene (2005) 1.04
Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function. J Biol Chem (2001) 1.02
Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice. PLoS One (2011) 1.00
DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells. Mol Endocrinol (2010) 0.99
Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression. PLoS One (2013) 0.99
Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis. Oncol Res (2003) 0.96
Androgenic control of transforming growth factor-beta signaling in prostate epithelial cells through transcriptional suppression of transforming growth factor-beta receptor II. Cancer Res (2008) 0.96
PET with the 89Zr-labeled transforming growth factor-β antibody fresolimumab in tumor models. J Nucl Med (2011) 0.95
Identification of function for CD44 intracytoplasmic domain (CD44-ICD): modulation of matrix metalloproteinase 9 (MMP-9) transcription via novel promoter response element. J Biol Chem (2012) 0.95
Novel permissive role of epidermal growth factor in transforming growth factor beta (TGF-beta) signaling and growth suppression. Mediation by stabilization of TGF-beta receptor type II. J Biol Chem (2006) 0.94
Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition. Cancer Res (2002) 0.93
Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. Int J Radiat Oncol Biol Phys (2008) 0.93
Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling. Biochem Pharmacol (2004) 0.91
Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. J Cell Physiol (2008) 0.91
Promoter-independent regulation of vimentin expression in mammary epithelial cells by val(12)ras and TGFbeta. Exp Cell Res (2007) 0.90
Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. Cancer Res (2010) 0.90
Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells. PLoS One (2013) 0.89
The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. J Biol Chem (2006) 0.89
Development and characterization of DP-153, a nontumorigenic prostatic cell line that undergoes malignant transformation by expression of dominant-negative transforming growth factor beta receptor type II. Cancer Res (2003) 0.89
A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells. Mol Pharmacol (2006) 0.85
Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells. Stem Cells Dev (2013) 0.85
Alterations of Smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma. Head Neck (2012) 0.85
Regulation of trespin expression by modulators of cell growth, differentiation, and apoptosis in prostatic epithelial cells. Exp Cell Res (2003) 0.84
Overexpression of Bax sensitizes prostate cancer cells to TGF-beta induced apoptosis. Cell Res (2005) 0.84
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition. Pigment Cell Melanoma Res (2011) 0.84
Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells. J Biol Chem (2013) 0.82
Luminal breast cancer metastasis is dependent on estrogen signaling. Clin Exp Metastasis (2012) 0.82
TGFbeta superfamily signaling: notes from the desert. Development (2007) 0.81
Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin. Mol Cancer Res (2012) 0.81
Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer. Breast Cancer Res Treat (2006) 0.81
Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. J Biol Chem (2010) 0.81
Identification and characterization of a novel rat ov-serpin family member, trespin. J Biol Chem (2002) 0.80
FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells. Mol Cancer Res (2008) 0.80
Bcl-2 antisense (G3139, Genasense) enhances the in vitro and in vivo response of Epstein-Barr virus-associated lymphoproliferative disease to rituximab. Clin Cancer Res (2003) 0.80
Defining regulatory elements in the human KAI1 (CD 82) metastasis suppressor gene. Prostate (2003) 0.78
Transforming growth factor (TGF)-β expression and activation mechanisms as potential targets for anti-tumor therapy and tumor imaging. Pharmacol Ther (2012) 0.78
17-Beta-estradiol induces neoplastic transformation in prostatic epithelial cells. Cancer Lett (2011) 0.77
A clinically motivated 2-fold framework for quantifying and classifying immunohistochemically stained specimens. Med Image Comput Comput Assist Interv (2007) 0.76
The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer Biol Ther (2009) 0.76
Decentralized data sharing of tissue microarrays for investigative research in oncology. Cancer Inform (2007) 0.76
Correspondence (letter to the editor): Explanation in the text would have been desirable. Dtsch Arztebl Int (2009) 0.75
[Medical aspects of left handedness]. Med Monatsschr Pharm (2002) 0.75
[Otorhinolaryngology--VI: Inhalation therapy--what Celsius already knew]. Pflege Z (2002) 0.75
[Otorhinolaryngology--4: Pro and contra of ear drops]. Pflege Z (2002) 0.75
Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. J Biol Chem (2015) 0.75
The RCVS codes of conduct: what's in a word? Vet Rec (2014) 0.75
[Analgesic intolerance: pathogenesis, diagnosis and treatment]. Med Monatsschr Pharm (2009) 0.75
[Otorhinolaryngology--VII: Cotton swabs have no business in ears]. Pflege Z (2002) 0.75
A young woman with recurrence of breast cancer. Cancer Pract (2002) 0.75
Proteome profile changes during transdifferentiation of NRP-152 rat prostatic basal epithelial cells. Mol Cells (2004) 0.75
Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer. Oncology (2005) 0.75
Sequential high-dose alkylating therapy and stem cell support for high-risk stage III breast cancer. Breast J (2003) 0.75
[Motion sickness. Findings and treatment]. Med Monatsschr Pharm (2003) 0.75
[Treatment of middle ear diseases]. Med Monatsschr Pharm (2002) 0.75
[Antiemetic therapy]. MMW Fortschr Med (2010) 0.75
[Otorhinolaryngology--V. Hemorrhage of the ENT area requires rapid management]. Pflege Z (2002) 0.75