Published in Trends Biochem Sci on July 01, 2003
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise. J Physiol (2005) 1.31
Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan. J Neurophysiol (2008) 0.97
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. J Biol Chem (2006) 0.84
Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Biochem Biophys Res Commun (2006) 0.84
Non-neuronal cholinergic system in airways and lung cancer susceptibility. Transl Lung Cancer Res (2013) 0.79
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity. Mol Cell (2012) 3.41
An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnol (2008) 3.27
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature (2012) 2.86
Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE). J Biol Chem (2011) 2.86
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein. Nature (2006) 2.77
The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution. Science (2008) 2.21
Structure of the DNA repair helicase XPD. Cell (2008) 2.16
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science (2005) 2.10
TarO: a target optimisation system for structural biology. Nucleic Acids Res (2008) 1.89
SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89
Pivotal roles of the outer membrane polysaccharide export and polysaccharide copolymerase protein families in export of extracellular polysaccharides in gram-negative bacteria. Microbiol Mol Biol Rev (2009) 1.82
Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature (2004) 1.70
The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics (2010) 1.66
A simple and efficient expression and purification system using two newly constructed vectors. Protein Expr Purif (2008) 1.64
Mechanism of the Class I KDPG aldolase. Bioorg Med Chem (2006) 1.62
Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol (2011) 1.59
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. EMBO J (2003) 1.58
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain. Nat Struct Mol Biol (2012) 1.53
Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli. Structure (2013) 1.51
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J (2006) 1.49
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48
CRISPR interference: a structural perspective. Biochem J (2013) 1.48
Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance. Nucleic Acids Res (2009) 1.38
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol (2007) 1.38
Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. J Biol Chem (2003) 1.37
The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli. Proc Natl Acad Sci U S A (2007) 1.36
MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL. Appl Magn Reson (2012) 1.34
Structural aspects of non-ribosomal peptide biosynthesis. Curr Opin Struct Biol (2004) 1.34
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. J Biol Chem (2005) 1.34
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol (2005) 1.30
Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett (2003) 1.25
Adenylate-forming enzymes. Curr Opin Struct Biol (2009) 1.23
Three-dimensional structure of Wza, the protein required for translocation of group 1 capsular polysaccharide across the outer membrane of Escherichia coli. J Biol Chem (2004) 1.21
Structure of the heterotrimeric PCNA from Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.21
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. J Biol Chem (2007) 1.21
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat Chem Biol (2009) 1.21
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction. Angew Chem Int Ed Engl (2013) 1.20
The fluorinase from Streptomyces cattleya is also a chlorinase. Angew Chem Int Ed Engl (2006) 1.13
Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. J Biol Chem (2005) 1.11
PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli. Angew Chem Int Ed Engl (2009) 1.10
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol (2006) 1.09
Toward a structural understanding of the dehydratase mechanism. Structure (2002) 1.08
NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond. Angew Chem Int Ed Engl (2010) 1.06
Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure (2002) 1.06
Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. J Mol Biol (2007) 1.04
Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy. Proc Natl Acad Sci U S A (2012) 1.03
The discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides. Chembiochem (2012) 1.02
Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate. Biochemistry (2003) 1.02
Structural, mechanistic and regulatory studies of serine palmitoyltransferase. Biochem Soc Trans (2012) 1.02
Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site. J Am Chem Soc (2005) 1.02
A novel outer membrane protein, Wzi, is involved in surface assembly of the Escherichia coli K30 group 1 capsule. J Bacteriol (2003) 1.01
An efficient method for the in vitro production of azol(in)e-based cyclic peptides. Angew Chem Int Ed Engl (2014) 0.99
Mechanism of enzymatic fluorination in Streptomyces cattleya. J Am Chem Soc (2007) 0.98
The chemical basis of serine palmitoyltransferase inhibition by myriocin. J Am Chem Soc (2013) 0.98
Structural insights into regioselectivity in the enzymatic chlorination of tryptophan. J Mol Biol (2009) 0.98
New insights into the mechanism of enzymatic chlorination of tryptophan. Angew Chem Int Ed Engl (2008) 0.97
The structure of NADH in the enzyme dTDP-d-glucose dehydratase (RmlB). J Am Chem Soc (2003) 0.97
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.97
Periplasmic export machines for outer membrane assembly. Curr Opin Struct Biol (2008) 0.96
A dimeric Rep protein initiates replication of a linear archaeal virus genome: implications for the Rep mechanism and viral replication. J Virol (2010) 0.96
Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30. Acta Crystallogr D Biol Crystallogr (2004) 0.95
Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria. Org Biomol Chem (2009) 0.95
Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly. J Mol Biol (2009) 0.94
Structural and mechanistic basis of bacterial sugar nucleotide-modifying enzymes. Biochemistry (2003) 0.93
Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. Org Biomol Chem (2011) 0.93
Structure of PatF from Prochloron didemni. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.92
Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis. Angew Chem Int Ed Engl (2011) 0.92
The structural basis of chain length control in Rv1086. J Mol Biol (2008) 0.91
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli. PLoS One (2011) 0.91
An enzymatic route to selenazolines. Chembiochem (2013) 0.90
Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes. RNA Biol (2013) 0.90
Low resolution structure of a bacterial SLC26 transporter reveals dimeric stoichiometry and mobile intracellular domains. J Biol Chem (2011) 0.90
Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales. Proc Natl Acad Sci U S A (2011) 0.90
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing. Biochem J (2013) 0.90
The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics. J Biol Chem (2009) 0.89
Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity. J Mol Biol (2009) 0.89
Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a. Mol Microbiol (2012) 0.88
Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa. J Mol Biol (2012) 0.88
The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step. J Biol Chem (2001) 0.87
Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus. J Mol Biol (2010) 0.87
Two-step purification of outer membrane proteins. Int J Biol Macromol (2006) 0.87
Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function. J Mol Biol (2011) 0.87
High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme. Structure (2003) 0.86
Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a. Acta Crystallogr D Biol Crystallogr (2012) 0.85
Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa. ACS Chem Biol (2013) 0.84
The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein. Biopolymers (2010) 0.84
Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chem Commun (Camb) (2008) 0.84
The respiratory arsenite oxidase: structure and the role of residues surrounding the rieske cluster. PLoS One (2013) 0.83
Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation. Blood (2014) 0.83
Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens. Acta Crystallogr D Biol Crystallogr (2004) 0.83
The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. J Biol Chem (2004) 0.83
Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog. Angew Chem Int Ed Engl (2008) 0.83
Characterization and crystal structure of Escherichia coli KDPGal aldolase. Bioorg Med Chem (2007) 0.82
Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation. Mol Biosyst (2010) 0.82
Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily. J Biol Chem (2010) 0.81
Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates. Org Biomol Chem (2006) 0.81
Crystallization and preliminary diffraction analysis of Wzi, a member of the capsule export and assembly pathway in Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.81