Published in Cancer Metastasis Rev on December 01, 2003
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36
Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (2010) 2.67
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
Engineered allosteric activation of kinases in living cells. Nat Biotechnol (2010) 2.44
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev (2010) 2.21
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. Cancer Res (2010) 1.95
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation. Mol Biol Cell (2009) 1.60
Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines. Eur J Nucl Med Mol Imaging (2005) 1.58
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood (2007) 1.54
Expression of FAK and PTEN in bronchioloalveolar carcinoma and lung adenocarcinoma. Lung (2009) 1.53
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest (2010) 1.50
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev (2014) 1.46
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PLoS One (2014) 1.39
Endothelial FAK is required for tumour angiogenesis. EMBO Mol Med (2010) 1.38
MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer (2008) 1.25
The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco Targets Ther (2010) 1.22
Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci (Landmark Ed) (2010) 1.20
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res (2005) 1.19
Multiple paxillin binding sites regulate FAK function. J Mol Signal (2008) 1.19
Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem (2008) 1.17
Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer (2011) 1.12
The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors. Int J Cancer (2010) 1.08
A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers. PLoS One (2013) 1.08
Inflammatory breast cancer (IBC): clues for targeted therapies. Breast Cancer Res Treat (2013) 1.08
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol (2005) 1.07
FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma. Clin Exp Metastasis (2012) 1.05
The human phosphatase interactome: An intricate family portrait. FEBS Lett (2012) 1.04
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog (2010) 1.01
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer (2009) 0.99
Clinical significance of focal adhesion kinase in resectable pancreatic cancer. World J Surg (2006) 0.99
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog (2009) 0.99
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Mol Biol Cell (2005) 0.99
DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene (2010) 0.99
Targeting FAK in human cancer: from finding to first clinical trials. Front Biosci (Landmark Ed) (2014) 0.99
Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression. Br J Cancer (2008) 0.98
Laminin-332-beta1 integrin interactions negatively regulate invadopodia. J Cell Physiol (2010) 0.98
Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. J Biol Chem (2011) 0.97
Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis. J Biol Chem (2012) 0.95
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. PLoS One (2012) 0.94
Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer. Clin Exp Metastasis (2008) 0.94
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal (2006) 0.94
Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. Clin Exp Metastasis (2007) 0.93
Targeting of the protein interaction site between FAK and IGF-1R. Biochem Biophys Res Commun (2009) 0.92
Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis. Clin Exp Metastasis (2005) 0.90
Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models. Cancer Biol Ther (2010) 0.89
Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling. Mol Cells (2012) 0.89
A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental response in Dictyostelium. Mol Biol Cell (2006) 0.88
Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. Cancer Lett (2013) 0.87
Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion. Cancers (Basel) (2015) 0.87
Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. J Cell Mol Med (2014) 0.86
Reduced paxillin expression contributes to the antimetastatic effect of 4-hydroxycoumarin on B16-F10 melanoma cells. Cancer Cell Int (2008) 0.86
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop. Cancer Lett (2011) 0.85
FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS One (2011) 0.85
Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog (2013) 0.85
uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma. PLoS One (2011) 0.84
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep (2014) 0.84
Expression of focal adhesion kinase in small-cell lung carcinoma. Cancer (2011) 0.83
Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach. Proteome Sci (2011) 0.82
FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res (2014) 0.82
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. Cell Death Dis (2013) 0.82
BRMS1 suppresses glioma progression by regulating invasion, migration and adhesion of glioma cells. PLoS One (2014) 0.81
Direct detection of protein biomarkers in human fluids using site-specific antibody immobilization strategies. Sensors (Basel) (2014) 0.81
Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases. Transl Oncol (2013) 0.81
Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB. PLoS One (2011) 0.81
Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain. PLoS One (2015) 0.81
Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15. J Cancer Res Clin Oncol (2015) 0.80
Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK. Microvasc Res (2007) 0.80
Zyxin is involved in regulation of mechanotransduction in arteriole smooth muscle cells. Front Physiol (2012) 0.80
PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation Res (2014) 0.79
Molecular Pathways: Endothelial Cell FAK-A Target for Cancer Treatment. Clin Cancer Res (2016) 0.79
Discovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular docking. Int J Mol Sci (2012) 0.79
Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog (2012) 0.79
Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis (2015) 0.78
Expression of cortactin and focal adhesion kinase in colorectal adenocarcinoma: correlation with clinicopathologic parameters and their prognostic implication. Korean J Pathol (2012) 0.78
Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med (2014) 0.78
Cell survival signaling in neuroblastoma. Anticancer Agents Med Chem (2013) 0.78
Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. PLoS One (2013) 0.78
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer (2014) 0.78
Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner. Small (2014) 0.77
Identification of interconnected markers for T-cell acute lymphoblastic leukemia. Biomed Res Int (2013) 0.77
Inhibition of FAK kinase activity preferentially targets cancer stem cells. Oncotarget (2017) 0.76
Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells. Biol Open (2012) 0.76
The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary. J Oncol (2010) 0.76
New insights into FAK phosphorylation based on a FAT domain-defective mutation. PLoS One (2014) 0.76
AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway. Oncol Lett (2016) 0.76
Targeting focal adhesion kinase in neuroblastoma. Anticancer Agents Med Chem (2010) 0.75
Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain. Exp Ther Med (2015) 0.75
Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer. Cancer Lett (2014) 0.75
Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies. Clin Cancer Drugs (2015) 0.75
Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53. Br J Cancer (2016) 0.75
The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breast Cancer Res (2016) 0.75
Cell Proliferation in Neuroblastoma. Cancers (Basel) (2016) 0.75
Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Transl Oncol (2016) 0.75
MAP kinases and cell migration. J Cell Sci (2004) 4.46
JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60
The interplay between Src and integrins in normal and tumor biology. Oncogene (2004) 3.37
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol (2004) 2.12
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest (2010) 2.04
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol (2003) 1.67
Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin Cancer Res (2005) 1.63
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. J Biol Chem (2005) 1.58
Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem (2005) 1.57
Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. J Cell Biol (2003) 1.49
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
FERM domain interaction promotes FAK signaling. Mol Cell Biol (2004) 1.34
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol Cell Biol (2006) 1.26
PTP-PEST controls motility through regulation of Rac1. J Cell Sci (2002) 1.24
Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'. Biochem J (2002) 1.20
Focal adhesion kinase: exploring Fak structure to gain insight into function. Int Rev Cell Mol Biol (2011) 1.19
Multiple paxillin binding sites regulate FAK function. J Mol Signal (2008) 1.19
NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model. J Biol Chem (2003) 1.17
New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate. Structure (2004) 1.11
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J Cell Biol (2004) 1.11
Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini. J Biol Chem (2008) 1.09
A role for JNK-paxillin signaling in cell migration. Cell Cycle (2004) 1.07
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. Am J Physiol Cell Physiol (2010) 1.04
CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis. Circ Res (2007) 1.04
Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Exp Cell Res (2008) 1.04
The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation. Structure (2004) 0.99
The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology. J Biol Chem (2002) 0.97
In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells. J Biol Chem (2005) 0.96
The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration. Mol Cancer Res (2013) 0.95
Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. Cancer (2002) 0.94
Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions. IUBMB Life (2007) 0.91
Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. J Biol Chem (2005) 0.91
Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro. J Cell Physiol (2009) 0.86
Identification of a filamin docking site on PTP-PEST. J Biol Chem (2006) 0.86
Vinculin tail conformation and self-association is independent of pH and H906 protonation. Biochemistry (2008) 0.84
Measurement of protein tyrosine phosphorylation in cell adhesion. Methods Mol Biol (2005) 0.80
In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by Src kinase. Biochemistry (2012) 0.79
Focal adhesion kinase-regulated signaling events in human cancer. Biomol Concepts (2012) 0.75