Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMC 167233)

Published in J Virol on August 01, 2003

Authors

Ali A Ashkar1, Stefan Bauer, William J Mitchell, Jeff Vieira, Kenneth L Rosenthal

Author Affiliations

1: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada L8N 3Z5. ashkara@mcmaster.ca

Articles citing this

Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol (2006) 4.21

The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques. J Virol (2005) 1.67

Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection. J Virol (2008) 1.24

Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10. J Neuroimmunol (2006) 1.18

A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest (2006) 1.16

Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. J Virol (2006) 1.16

Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc (2007) 1.12

Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo. J Leukoc Biol (2009) 1.12

Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes. J Virol (2006) 1.09

NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J Virol (2005) 1.08

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. PLoS Pathog (2008) 1.06

Toll-like receptors and viruses: induction of innate antiviral immune responses. Open Microbiol J (2008) 1.04

Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. Immunol Invest (2011) 1.04

Contrasting roles for TLR ligands in HIV-1 pathogenesis. PLoS One (2010) 0.97

Short- and long-term changes in gene expression mediated by the activation of TLR9. Mol Immunol (2009) 0.95

Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry. Antimicrob Agents Chemother (2008) 0.94

Mucosal delivery of CpG oligodeoxynucleotides expands functional dendritic cells and macrophages in the vagina. Immunology (2005) 0.94

Effects of particle size on toll-like receptor 9-mediated cytokine profiles. Biomaterials (2010) 0.92

Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol (2012) 0.90

Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction. Infect Immun (2009) 0.88

Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections. Mol Vis (2009) 0.88

Differential inhibition of human cytomegalovirus (HCMV) by toll-like receptor ligands mediated by interferon-beta in human foreskin fibroblasts and cervical tissue. Virol J (2007) 0.87

Tweaking Innate Immunity: the Promise of Innate Immunologicals As Anti-infectives. Can J Infect Dis Med Microbiol (2006) 0.86

Chemokines and Chemokine Receptors Critical to Host Resistance following Genital Herpes Simplex Virus Type 2 (HSV-2) Infection. Open Immunol J (2008) 0.85

Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA. J Leukoc Biol (2012) 0.84

Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells. BMC Biotechnol (2008) 0.82

Expression of toll-like receptors in genital tract tissues from normal and HIV-infected men. Am J Reprod Immunol (2011) 0.82

Broad-spectrum drugs against viral agents. Int J Mol Sci (2008) 0.81

Influence of the tissue microenvironment on Toll-like receptor expression by CD11c+ antigen-presenting cells isolated from mucosal tissues. Clin Vaccine Immunol (2009) 0.81

Prophylactic and therapeutic modulation of innate and adaptive immunity against mucosal infection of herpes simplex virus. Immune Netw (2014) 0.80

Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2. J Virol (2008) 0.78

HSV type 2 infection increases HIV DNA detection in vaginal tissue of mice expressing human CD4 and CCR5. AIDS Res Hum Retroviruses (2009) 0.77

Articles cited by this

Innate immune recognition. Annu Rev Immunol (2001) 26.65

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol (2001) 9.19

Decoding the patterns of self and nonself by the innate immune system. Science (2002) 7.19

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A (2001) 5.02

Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology (1997) 2.37

T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2. J Immunol (1998) 2.31

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J Immunol (1998) 2.31

Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. J Virol (1984) 2.29

Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol (1999) 2.23

The role of gamma interferon in immune resistance to vaginal infection by herpes simplex virus type 2 in mice. Virology (1999) 1.93

Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J Immunol (2001) 1.84

A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol (2003) 1.76

The role of CpG motifs in innate immunity. Curr Opin Immunol (2000) 1.74

Differential roles of B cells and IFN-gamma-secreting CD4(+) T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice. J Gen Virol (2001) 1.67

Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc Natl Acad Sci U S A (1999) 1.59

The role of CpG dinucleotides in DNA vaccines. Trends Microbiol (1998) 1.57

Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun (2001) 1.55

Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes. J Virol (1998) 1.47

Toll-like receptor 9 mediates CpG-DNA signaling. J Leukoc Biol (2002) 1.42

Immunoglobulin G is the main protective antibody in mouse vaginal secretions after vaginal immunization with attenuated herpes simplex virus type 2. J Virol (1997) 1.37

Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity. J Virol (2001) 1.36

Humoral response to herpes simplex virus is complement-dependent. Proc Natl Acad Sci U S A (1999) 1.35

Neutrophils aid in protection of the vaginal mucosae of immune mice against challenge with herpes simplex virus type 2. J Virol (1999) 1.35

T lymphocytes in genital lymph nodes protect mice from intravaginal infection with herpes simplex virus type 2. J Infect Dis (1989) 1.33

Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infect Immun (1999) 1.32

Role of mucosal immunity in herpes simplex virus infection. J Immunol (1998) 1.29

Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J Virol (2002) 1.19

CpG oligodeoxynucleotides enhance host defense during murine tuberculosis. Infect Immun (2002) 1.16

Toll-like receptor 9, CpG DNA and innate immunity. Curr Mol Med (2002) 1.10

Now I know my CpGs. Trends Microbiol (2001) 1.06

In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis. J Neuroimmunol (1999) 1.06

Tetracycline-inducible system for photoreceptor-specific gene expression. Invest Ophthalmol Vis Sci (2000) 1.03

Protective vaccination against genital herpes simplex virus type 2 (HSV-2) infection in mice is associated with a rapid induction of local IFN-gamma-dependent RANTES production following a vaginal viral challenge. Am J Reprod Immunol (2001) 0.96

Neurons differentially control expression of a herpes simplex virus type 1 immediate-early promoter in transgenic mice. J Virol (1995) 0.93

The transgenic ICP4 promoter is activated in Schwann cells in trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Virol (2001) 0.92

Nitric oxide and macrophage antiviral extrinsic activity. Immunology (1999) 0.91

Articles by these authors

(truncated to the top 100)

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Toward a systems approach to understanding plant cell walls. Science (2004) 5.60

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol (2002) 4.21

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol (2002) 4.12

The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol (2003) 3.17

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med (2005) 3.10

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med (2005) 2.89

Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol (2004) 2.80

Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci U S A (2004) 2.79

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science (2012) 2.66

CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology (2006) 2.39

Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity (2012) 2.35

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23

Progesterone increases susceptibility and decreases immune responses to genital herpes infection. J Virol (2003) 2.04

Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J Immunol (2005) 2.02

The Arabidopsis irregular xylem8 mutant is deficient in glucuronoxylan and homogalacturonan, which are essential for secondary cell wall integrity. Plant Cell (2007) 1.98

Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest (2004) 1.96

The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS). IEEE Trans Med Imaging (2014) 1.91

Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J Virol (2003) 1.83

Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology (2005) 1.83

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood (2005) 1.74

Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J (2004) 1.60

Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology (2009) 1.57

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS (2008) 1.55

Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts. Arthritis Rheum (2010) 1.52

Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. Gastroenterology (2007) 1.49

Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J Virol (2003) 1.46

Intraoperative transit time flow measurement: off-pump versus on-pump coronary artery bypass. Ann Thorac Surg (2005) 1.46

Risk in elderly patients after stentless versus stented aortic valve surgery. Asian Cardiovasc Thorac Ann (2003) 1.41

The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med (2012) 1.41

Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA. J Infect Dis (2004) 1.36

HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers. PLoS One (2009) 1.35

Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. J Immunol (2008) 1.30

CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur J Immunol (2002) 1.23

Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology (2007) 1.23

Rational development of high-affinity T-cell receptor-like antibodies. Proc Natl Acad Sci U S A (2009) 1.23

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int Immunol (2006) 1.21

TLR9 contributes to antiviral immunity during gammaherpesvirus infection. J Immunol (2008) 1.20

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs. J Immunol (2011) 1.20

The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun (2010) 1.19

Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. J Virol (2009) 1.18

Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J Immunol (2003) 1.18

CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA. Eur J Immunol (2006) 1.15

Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissue. J Virol (2005) 1.14

Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. J Immunol (2007) 1.12

Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep (2010) 1.11

West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection. J Neurovirol (2007) 1.10

Toll-like receptor 9, CpG DNA and innate immunity. Curr Mol Med (2002) 1.10

A comparative systems analysis of polysaccharide-elicited responses in Neurospora crassa reveals carbon source-specific cellular adaptations. Mol Microbiol (2013) 1.10

NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J Virol (2005) 1.08

Chitinase-like1/pom-pom1 and its homolog CTL2 are glucan-interacting proteins important for cellulose biosynthesis in Arabidopsis. Plant Cell (2012) 1.08

Intravaginal infection with herpes simplex virus type-2 (HSV-2) generates a functional effector memory T cell population that persists in the murine genital tract. J Reprod Immunol (2010) 1.07

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. Cell Microbiol (2011) 1.07

Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammation. J Virol (2005) 1.06

Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology (2009) 1.06

Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine (2004) 1.04

A new method for isolating large quantities of Arabidopsis trichomes for transcriptome, cell wall and other types of analyses. Plant J (2008) 1.04

All is not Toll: new pathways in DNA recognition. J Exp Med (2006) 1.03

Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women. Antiviral Res (2008) 1.02

Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection. Biol Reprod (2007) 0.99

Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells. Immunobiology (2006) 0.99

Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge. J Med Virol (2003) 0.98

Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes. Biotechnol Biofuels (2014) 0.97

Neurons differentially activate the herpes simplex virus type 1 immediate-early gene ICP0 and ICP27 promoters in transgenic mice. J Virol (2002) 0.97

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res (2011) 0.97

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. Eur Heart J (2011) 0.97

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells. Immunobiology (2009) 0.97

Theoretical studies on conjugated phenyl-cored thiophene dendrimers for photovoltaic applications. J Am Chem Soc (2007) 0.96

Biochemical analyses of multiple endoxylanases from the rumen bacterium Ruminococcus albus 8 and their synergistic activities with accessory hemicellulose-degrading enzymes. Appl Environ Microbiol (2011) 0.96

Engineering Escherichia coli for biodiesel production utilizing a bacterial fatty acid methyltransferase. Appl Environ Microbiol (2011) 0.96

Roles of small laccases from Streptomyces in lignin degradation. Biochemistry (2014) 0.95

TLR9-mediated recognition of DNA. Handb Exp Pharmacol (2008) 0.95

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates. Mol Syst Biol (2013) 0.95

Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J Infect Dis (2002) 0.94

Mucosal delivery of CpG oligodeoxynucleotides expands functional dendritic cells and macrophages in the vagina. Immunology (2005) 0.94

CD8+ T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides. J Virol (2005) 0.93

Multiple tandem copies of conserved gp41 epitopes incorporated in gag virus-like particles elicit systemic and mucosal antibodies in an optimized heterologous vector delivery regimen. Vaccine (2010) 0.93

Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses. Int Immunol (2009) 0.93

Enhancing tolerance to short-chain alcohols by engineering the Escherichia coli AcrB efflux pump to secrete the non-native substrate n-butanol. ACS Synth Biol (2013) 0.92

NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc Natl Acad Sci U S A (2005) 0.92

Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS One (2009) 0.92

War and peace between WAP and HIV: role of SLPI, trappin-2, elafin and ps20 in susceptibility to HIV infection. Biochem Soc Trans (2011) 0.92

Treatment of POEMS syndrome with bevacizumab. Haematologica (2007) 0.92

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX. Eur J Pharmacol (2011) 0.91

Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8. Immunobiology (2009) 0.90

Characterization of conserved viral leader RNA sequences that stimulate innate immunity through TLRs. Oligonucleotides (2007) 0.90

Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. Int Immunol (2007) 0.90

Adenoviral delivery of interleukin-10 fails to attenuate experimental Lyme disease. Infect Immun (2008) 0.90

CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells. FEBS J (2007) 0.90

Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848). Antiviral Res (2005) 0.90

Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun (2008) 0.89

Identification of novel biomass-degrading enzymes from genomic dark matter: Populating genomic sequence space with functional annotation. Biotechnol Bioeng (2014) 0.88

Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells. J Virol (2012) 0.88

Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells. Blood (2011) 0.87

Expression of Toll-like receptors in murine vaginal epithelium is affected by the estrous cycle and stromal cells. J Reprod Immunol (2007) 0.87

A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells. Blood (2008) 0.87

Vaccines in the public eye. Nat Med (2005) 0.87

Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete. BMJ Case Rep (2013) 0.86

A major role for TLR8 in the recognition of vaccinia viral DNA by murine pDC? Proc Natl Acad Sci U S A (2010) 0.85

Nucleic acid recognizing Toll-like receptors and autoimmunity. Curr Opin Immunol (2007) 0.85