Innate immune recognition.

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75

Defective CD8 T cell memory following acute infection without CD4 T cell help. Science (2003) 9.67

Inflammation in prostate carcinogenesis. Nat Rev Cancer (2007) 9.08

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 6.01

In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med (2004) 5.07

Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest (2006) 4.92

Pyogenic bacterial infections in humans with MyD88 deficiency. Science (2008) 4.92

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci U S A (2004) 4.84

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog (2007) 4.73

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev (2006) 4.61

Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56

Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A (2003) 4.33

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell (2005) 4.30

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J (2005) 4.18

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99

Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol (2003) 3.97

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med (2005) 3.85

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc Natl Acad Sci U S A (2002) 3.85

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74

Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci U S A (2009) 3.74

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72

Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 3.70

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest (2004) 3.69

Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol (2010) 3.67

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61

Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol (2009) 3.60

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med (2005) 3.59

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A (2005) 3.59

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling. J Clin Invest (2007) 3.54

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46

Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol (2012) 3.43

Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A (2005) 3.35

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci U S A (2008) 3.27

Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20

Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13

Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol (2009) 3.09

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A (2003) 3.02

Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog (2005) 3.01

From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98

Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity (2009) 2.91

A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A (2006) 2.91

Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A (2004) 2.89

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88

Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion. Clin Microbiol Rev (2008) 2.86

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol (2006) 2.83

IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol (2009) 2.83

Nanomedicine--challenge and perspectives. Angew Chem Int Ed Engl (2009) 2.74

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol (2012) 2.72

The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med (2007) 2.71

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med (2005) 2.66

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med (2005) 2.64

Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med (2010) 2.61

Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev (2003) 2.59

Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol (2007) 2.59

Modulation of adaptive immunity with Toll-like receptors. Semin Immunol (2009) 2.56

Central roles of NLRs and inflammasomes in viral infection. Nat Rev Immunol (2010) 2.54

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med (2009) 2.51

The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med (2005) 2.50

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nat Rev Immunol (2013) 2.49

Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49

Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol (2004) 2.47

Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol (2008) 2.44

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity (2009) 2.44

Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A (2005) 2.39

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med (2003) 2.39

The role of synovitis in osteoarthritis pathogenesis. Bone (2012) 2.37

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med (2012) 2.36

The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota. Clin Microbiol Rev (2006) 2.36

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35

Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci U S A (2005) 2.35

West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling. J Virol (2006) 2.32

The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (2010) 2.29

Toll-like receptors as targets in chronic liver diseases. Gut (2009) 2.29

Plasmacytoid dendritic cells: linking innate and adaptive immunity. J Virol (2005) 2.28

PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev (2012) 2.24

The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23

MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest (2005) 2.20

Genomic insights into the immune system of the sea urchin. Science (2006) 2.20

Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe (2008) 2.18

Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax (2006) 2.18

Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol (2014) 2.11

TLR-based immune adjuvants. Vaccine (2010) 2.10

Cell biology of cnidarian-dinoflagellate symbiosis. Microbiol Mol Biol Rev (2012) 2.10

Immune-like phagocyte activity in the social amoeba. Science (2007) 2.10

Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells. Immunity (2010) 2.09

Coagulation factor X activates innate immunity to human species C adenovirus. Science (2012) 2.09

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43

Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30

Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11

Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09

Allergic host defences. Nature (2012) 1.99

Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80

Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57

Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56

Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52

The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36

Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35

Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34

Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21

Learning tolerance while fighting ignorance. Cell (2009) 1.20

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14

Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

Two modes of ligand recognition by TLRs. Cell (2007) 0.99

Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97

Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94

Antifungal defense turns 17. Nat Immunol (2007) 0.93

Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90

Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89

Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89

A new shield for a cytokine storm. Cell (2011) 0.88

graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85

The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84

Skin antibiotics get in the loop. Nat Med (2002) 0.84

Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82

A plague on host defense. J Exp Med (2002) 0.81

T helper 17 cells get the NOD. Immunity (2007) 0.78

Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78

Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76

Innovating immunology: an interview with Ruslan Medzhitov. Dis Model Mech (2011) 0.75

Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75