Published in Mol Cell on July 01, 2003
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. Genes Dev (2004) 2.08
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat Rev Microbiol (2009) 1.81
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
Adaptor-dependent degradation of a cell-cycle regulator uses a unique substrate architecture. Structure (2012) 1.62
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC. EMBO J (2006) 1.49
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags. Proc Natl Acad Sci U S A (2004) 1.13
The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease. Urolithiasis (2013) 1.08
Tuning the strength of a bacterial N-end rule degradation signal. J Biol Chem (2008) 1.08
Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. J Bacteriol (2006) 1.03
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX. Proc Natl Acad Sci U S A (2006) 1.02
Structural insights into the conformational diversity of ClpP from Bacillus subtilis. Mol Cells (2011) 0.96
Engineering synthetic adaptors and substrates for controlled ClpXP degradation. J Biol Chem (2009) 0.92
Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8. Nat Commun (2013) 0.88
Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species. Protein Sci (2010) 0.86
Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX. J Mol Biol (2015) 0.83
A degradation signal recognition in prokaryotes. J Synchrotron Radiat (2008) 0.79
A queueing approach to multi-site enzyme kinetics. Interface Focus (2014) 0.76
The propagation of perturbations in rewired bacterial gene networks. Nat Commun (2015) 0.75
ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils. Sci Rep (2017) 0.75
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med (2005) 26.35
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell (2005) 17.41
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A (2008) 8.08
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature (2009) 7.05
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell (2007) 5.95
Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem (2007) 5.36
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell (2007) 4.85
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov (2011) 4.80
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell (2004) 3.51
Structure and regulation of Src family kinases. Oncogene (2004) 3.44
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell (2004) 3.43
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A (2002) 3.28
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res (2010) 3.16
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A (2012) 3.06
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell (2003) 2.77
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol (2007) 2.43
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
SAP couples Fyn to SLAM immune receptors. Nat Cell Biol (2003) 2.27
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol (2003) 2.26
Structure of the autoinhibitory switch in formin mDia1. Structure (2006) 2.26
The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol (2010) 2.23
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol (2003) 2.23
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood (2005) 1.73
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med (2012) 1.65
Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem (2005) 1.57
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med (2013) 1.56
EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma. Clin Cancer Res (2011) 1.50
Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (2003) 1.48
Structure and function of the interacting domains of Spire and Fmn-family formins. Proc Natl Acad Sci U S A (2011) 1.36
FERM domain interaction promotes FAK signaling. Mol Cell Biol (2004) 1.34
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol (2007) 1.29
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood (2004) 1.27
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discov (2014) 1.26
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc Natl Acad Sci U S A (2013) 1.22
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (2003) 1.21
Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep (2013) 1.17
Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem (2003) 1.13
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One (2008) 1.11
Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol (2010) 1.07
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol (2010) 1.05
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol (2004) 1.04
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol (2002) 1.02
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol (2013) 1.01
Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization. Cancer Res (2013) 1.00
The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Mol Cell (2008) 0.96
Crystal structure of a coiled-coil domain from human ROCK I. PLoS One (2011) 0.95
Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol (2013) 0.94
Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. PLoS One (2010) 0.93
Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6. Proc Natl Acad Sci U S A (2012) 0.90
Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. J Biol Chem (2003) 0.89
Specificity in signaling by c-Yes. Front Biosci (2003) 0.89
Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer (2014) 0.80
Assembling atomic resolution views of the immunological synapse. Curr Opin Immunol (2003) 0.75