The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.

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Published in Proc Natl Acad Sci U S A on January 28, 2008

Authors

Cai-Hong Yun1, Kristen E Mengwasser, Angela V Toms, Michele S Woo, Heidi Greulich, Kwok-Kin Wong, Matthew Meyerson, Michael J Eck

Author Affiliations

1: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

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