Published in J Pharmacol Exp Ther on July 31, 2003
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol (2009) 1.49
Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal (2009) 1.18
Liver tissue engineering in the evaluation of drug safety. Expert Opin Drug Metab Toxicol (2009) 1.17
Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? J Pharmacol Exp Ther (2009) 1.14
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacol Rev (2009) 1.12
Idiosyncratic adverse drug reactions: current concepts. Pharmacol Rev (2013) 1.12
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci (2013) 1.07
Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicol Sci (2010) 1.06
Mechanisms of drug-induced liver injury. Clin Liver Dis (2013) 0.99
Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicol Sci (2008) 0.96
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicol Sci (2008) 0.94
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2007) 0.93
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2008) 0.92
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. Int J Mol Sci (2010) 0.91
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicol Sci (2011) 0.89
Role of animal models in the study of drug-induced hypersensitivity reactions. AAPS J (2006) 0.88
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. Toxicol Sci (2009) 0.85
Drug-induced hepatotoxicity: metabolic, genetic and immunological basis. Int J Mol Sci (2014) 0.85
Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol (2012) 0.81
The role of the immune system in nevirapine-induced subclinical liver injury of a rat model. ISRN Pharm (2012) 0.80
Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase. J Pharmacol Exp Ther (2014) 0.79
Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α. Am J Physiol Gastrointest Liver Physiol (2012) 0.76
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress. Toxicol Sci (2012) 0.75
Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide. Toxicol Sci (2013) 0.75
The Influence of histamine H1-receptor on liver functions in immunized rabbits. Saudi J Biol Sci (2011) 0.75
Concurrent Inflammation Augments Antimalarial Drugs-Induced Liver Injury in Rats. Adv Pharm Bull (2016) 0.75
Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ. Acta Pharmacol Sin (2017) 0.75
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Gastroenterology (2006) 3.53
Comparing the Gleason prostate biopsy and Gleason prostatectomy grading system: the Lahey Clinic Medical Center experience and an international meta-analysis. Eur Urol (2008) 2.77
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci (2006) 1.75
Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chem Biol Interact (2004) 1.49
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicol Sci (2007) 1.45
Closing the supply versus demand gap for veterinary pathologists: a multifaceted problem in need of a multifaceted solution. Vet Clin Pathol (2005) 1.39
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (2007) 1.23
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther (2005) 1.15
Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? J Pharmacol Exp Ther (2009) 1.14
Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure. Toxicol Sci (2003) 1.13
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacol Rev (2009) 1.12
Metformin prevents endotoxin-induced liver injury after partial hepatectomy. J Pharmacol Exp Ther (2005) 1.12
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury. Toxicol Sci (2007) 1.09
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. J Pharmacol Exp Ther (2006) 1.07
Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2005) 1.06
Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicol Sci (2010) 1.06
Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. Toxicol Sci (2002) 1.06
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology (2004) 1.06
Inflammation and drug idiosyncrasy--is there a connection? J Pharmacol Exp Ther (2003) 1.05
Hypoxia, drug therapy and toxicity. Pharmacol Ther (2006) 1.04
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? J Pharmacol Exp Ther (2002) 1.01
Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. J Toxicol Environ Health A (2010) 1.01
Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure. J Pharmacol Exp Ther (2008) 0.99
Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicol Lett (2004) 0.97
Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicol Sci (2008) 0.96
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system. Toxicol In Vitro (2006) 0.94
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicol Sci (2008) 0.94
Modes of cell death in rat liver after monocrotaline exposure. Toxicol Sci (2003) 0.94
Workshop overview: Hepatotoxicity assessment for botanical dietary supplements. Toxicol Sci (2004) 0.93
Animal models of idiosyncratic drug-induced liver injury--current status. Crit Rev Toxicol (2011) 0.93
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2007) 0.93
Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers. J Pharmacol Exp Ther (2003) 0.93
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. J Pharmacol Exp Ther (2009) 0.92
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2008) 0.92
Complement activation in acetaminophen-induced liver injury in mice. J Pharmacol Exp Ther (2012) 0.91
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. Int J Mol Sci (2010) 0.91
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2011) 0.90
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicol Sci (2011) 0.89
Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice. J Pharmacol Exp Ther (2009) 0.89
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. Shock (2002) 0.89
Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicol Sci (2013) 0.89
Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure. Toxicology (2006) 0.88
The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury. Toxicol Sci (2003) 0.87
Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology (2010) 0.86
A mouse model of severe halothane hepatitis based on human risk factors. J Pharmacol Exp Ther (2010) 0.86
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. Toxicol Sci (2009) 0.85
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice. Toxicol Sci (2010) 0.85
Liver inflammation during monocrotaline hepatotoxicity. Toxicology (2003) 0.85
The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability. Toxicol Appl Pharmacol (2009) 0.85
Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system. Toxicol Sci (2003) 0.84