Published in Nat Rev Neurosci on August 01, 2003
Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci U S A (2007) 1.96
Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid Med Cell Longev (2010) 1.66
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci (2009) 1.64
Identification of a novel inhibitor of the canonical Wnt pathway. Mol Cell Biol (2011) 1.38
Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. J Lipid Res (2008) 1.36
Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor. J Biol Chem (2009) 1.36
Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J Biol Chem (2009) 1.34
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat Rev Cancer (2013) 1.31
A mouse model for human osteogenesis imperfecta type VI. J Bone Miner Res (2013) 1.27
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes (2011) 1.25
Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA. Invest Ophthalmol Vis Sci (2009) 1.20
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proc Natl Acad Sci U S A (2010) 1.17
C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes (2012) 1.16
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Diabetes Res Clin Pract (2008) 1.13
Differential expression of anti-angiogenic factors and guidance genes in the developing macula. Mol Vis (2009) 1.12
'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'. Oncogene (2009) 1.12
Codon preference optimization increases heterologous PEDF expression. PLoS One (2010) 1.10
Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery. Prostaglandins Leukot Essent Fatty Acids (2010) 1.07
Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice. Mol Med (2012) 1.06
Alteration of growth factors and neuronal death in diabetic retinopathy: what we have learned so far. Mol Vis (2011) 1.05
Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Invest Ophthalmol Vis Sci (2009) 1.05
Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells. Proc Natl Acad Sci U S A (2006) 1.05
Molecular parallels between neural and vascular development. Cold Spring Harb Perspect Med (2013) 1.05
PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration. Exp Eye Res (2008) 1.04
Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. Am J Physiol Endocrinol Metab (2009) 1.00
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate. Cell Death Dis (2012) 0.99
Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. Invest Ophthalmol Vis Sci (2013) 0.99
Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity. Arch Ophthalmol (2010) 0.98
A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. BMC Neurol (2005) 0.96
Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. J Biol Chem (2008) 0.96
Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1/2 and induction of Bcl-2. Neurosci Res (2011) 0.94
Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv Exp Med Biol (2008) 0.94
Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy. Mol Vis (2008) 0.93
Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1. Stem Cells (2008) 0.93
Pigment epithelium-derived factor secreted from retinal pigment epithelium facilitates apoptotic cell death of iPSC. Sci Rep (2013) 0.93
Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1. Am J Pathol (2011) 0.91
Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes. Arch Ophthalmol (2009) 0.90
Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology. Neuropsychopharmacology (2011) 0.90
The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts. J Cell Mol Med (2010) 0.90
Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels. PLoS One (2012) 0.89
PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers. J Biomed Biotechnol (2012) 0.87
Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells. Am J Pathol (2009) 0.87
Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization. Mol Vis (2009) 0.86
Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury. Invest Ophthalmol Vis Sci (2013) 0.85
Targeting Neovascularization in Ischemic Retinopathy: Recent Advances. Expert Rev Ophthalmol (2013) 0.84
Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. BMC Genomics (2006) 0.84
The PEDF Neuroprotective Domain Plus DHA Induces Corneal Nerve Regeneration After Experimental Surgery. Invest Ophthalmol Vis Sci (2015) 0.84
Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. Prostaglandins Leukot Essent Fatty Acids (2012) 0.83
Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism. PLoS One (2012) 0.83
Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients. J Diabetes Complications (2014) 0.82
The yin and yang of VEGF and PEDF: multifaceted neurotrophic factors and their potential in the treatment of Parkinson's Disease. Int J Mol Sci (2010) 0.82
Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration. Mol Ther (2017) 0.81
PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium. Am J Physiol Lung Cell Mol Physiol (2013) 0.81
Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. Elife (2014) 0.80
[Survival factors in the treatment of hereditary retinal degeneration]. Ophthalmologe (2005) 0.80
Angiogenesis in diabetes and obesity. Rev Endocr Metab Disord (2015) 0.80
PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci (2012) 0.79
Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Mol Vis (2011) 0.79
Primary retinal cultures as a tool for modeling diabetic retinopathy: an overview. Biomed Res Int (2015) 0.79
Administration of pigment epithelium-derived factor prolongs bleeding time by suppressing plasminogen activator inhibitor-1 activity and platelet aggregation in rats. Clin Exp Med (2008) 0.78
Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury. BMC Genomics (2014) 0.78
Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. Neoplasia (2014) 0.78
Analysis of three pigment epithelium-derived factor gene polymorphisms in patients with exudative age-related macular degeneration. Mol Vis (2009) 0.78
Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration. Mol Cell Neurosci (2015) 0.78
Circulating levels and subcutaneous adipose tissue gene expression of pigment epithelium-derived factor in polycystic ovary syndrome and normal women: a case control study. Reprod Biol Endocrinol (2013) 0.78
Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy. Spine (Phila Pa 1976) (2015) 0.77
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease. J Dev Biol (2015) 0.77
Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor. Methods Enzymol (2011) 0.77
Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. Mol Med Rep (2014) 0.77
Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy. J Ophthalmol (2010) 0.76
Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. J Exp Clin Cancer Res (2016) 0.75
Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy. J Ophthalmol (2015) 0.75
Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq. BMC Genomics (2016) 0.75
Neural Stem Cell-based Intraocular Administration of Pigment Epithelium-derived Factor Promotes Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Crush Injury in Rat: An Experimental Study. Iran J Med Sci (2016) 0.75
Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI. Rare Dis (2016) 0.75
Emetine Di-HCl attenuates Type 1 diabetes mellitus in mice. Mol Med (2016) 0.75
Electroconvulsive therapy modulates plasma pigment epithelium-derived factor in depression: a proteomics study. Transl Psychiatry (2017) 0.75
Contemporary Approaches for Identifying Rare Bone Disease Causing Genes. Bone Res (2015) 0.75
Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women - a multivariate explorative cross-sectional study. J Pain Res (2017) 0.75
A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration. Biol Open (2017) 0.75
Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons. Parkinsons Dis (2017) 0.75
Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. Brain Res Bull (2015) 0.75
PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection. Exp Eye Res (2017) 0.75
Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci (2005) 1.67
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology (2003) 1.50
A biphasic pattern of gene expression during mouse retina development. BMC Dev Biol (2006) 1.14
Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends Mol Med (2003) 1.11
A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp Eye Res (2006) 1.09
STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation. Exp Eye Res (2005) 1.07
Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice. Mol Med (2012) 1.06
PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases. Biochem Biophys Res Commun (2006) 1.04
STAT3 activation protects retinal ganglion cell layer neurons in response to stress. Exp Eye Res (2008) 1.02
STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina. Invest Ophthalmol Vis Sci (2004) 1.02
Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol (2009) 1.02
Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology (2003) 1.00
PEDF and the serpins: phylogeny, sequence conservation, and functional domains. J Struct Biol (2005) 0.95
Stage and gene specific signatures defined by histones H3K4me2 and H3K27me3 accompany mammalian retina maturation in vivo. PLoS One (2012) 0.93
Expression and activation of STAT proteins during mouse retina development. Exp Eye Res (2003) 0.93
Molecular aspects of vertebrate retinal development. Mol Neurobiol (2002) 0.92
Tissue culture studies of retinal development. Methods (2002) 0.89
Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci (2008) 0.89
Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool. Glia (2013) 0.85
Comprehensive in silico functional specification of mouse retina transcripts. BMC Genomics (2005) 0.85
Protective effect of arachidonic acid on glutamate neurotoxicity in rat retinal ganglion cells. Invest Ophthalmol Vis Sci (2002) 0.85
Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. BMC Genomics (2006) 0.84
Specific protein kinase C isoforms are required for rod photoreceptor differentiation. J Neurosci (2011) 0.82
cGMP-induced presynaptic depression and postsynaptic facilitation at glutamatergic synapses in visual cortex. Brain Res (2002) 0.82
Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina. J Biol Chem (2013) 0.82
Comparison of gene expression during in vivo and in vitro postnatal retina development. J Ocul Biol Dis Infor (2008) 0.82
CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res (2013) 0.80
Developmental and tissue expression patterns of mouse Mpp4 gene. Biochem Biophys Res Commun (2003) 0.79
Space flight environment induces degeneration in the retina of rat neonates. Adv Exp Med Biol (2006) 0.77
Cell type-specific epigenetic signatures accompany late stages of mouse retina development. Adv Exp Med Biol (2014) 0.77
MAPK signaling during Müller glial cell development in retina explant cultures. J Ocul Biol Dis Infor (2011) 0.76
[Purified mouse retinal ganglion cell culture]. Zhonghua Yan Ke Za Zhi (2011) 0.76
Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. J Mol Neurosci (2014) 0.75
Epigenetics rules. J Ocul Biol Dis Infor (2012) 0.75
Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling. Adv Exp Med Biol (2010) 0.75