Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMID 12960023)

Published in Endocrinology on August 21, 2003

Authors

Sabrina Diano1, Russell T Matthews, Peter Patrylo, Lichuan Yang, M Flint Beal, Colin J Barnstable, Tamas L Horvath

Author Affiliations

1: Department of Obstetrics and Gynecology, Yale Medical School, 333 Cedar Street, New Haven Connecticut 06520, USA.

Articles citing this

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39

Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab (2009) 1.78

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nat Cell Biol (2011) 1.76

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol (2009) 1.63

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci (2009) 1.50

The ketogenic diet in a pill: is this possible? Epilepsia (2008) 1.28

Brain circuits regulating energy homeostasis. Regul Pept (2008) 1.24

Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23

Role of oxidative stress in epileptic seizures. Neurochem Int (2011) 1.20

Neurometabolism in human epilepsy. Epilepsia (2008) 1.12

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest (2015) 1.09

Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease. Transl Neurodegener (2012) 1.06

Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction. Ann N Y Acad Sci (2008) 1.06

Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci (2008) 1.06

Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab (2008) 1.02

Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning. Am J Physiol Heart Circ Physiol (2013) 0.98

Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF? Br J Pharmacol (2014) 0.96

Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan. Ageing Res Rev (2006) 0.92

Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol (2009) 0.91

Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotox Res (2009) 0.89

Mitochondria: the missing link between preconditioning and neuroprotection. J Alzheimers Dis (2010) 0.88

Functional characterization of a Drosophila mitochondrial uncoupling protein. J Bioenerg Biomembr (2004) 0.87

New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation. Front Neuroendocrinol (2010) 0.87

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection. J Bioenerg Biomembr (2014) 0.85

Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation. PLoS One (2012) 0.85

Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. J Neuroinflammation (2012) 0.84

UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PLoS One (2012) 0.83

Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia. J Bioenerg Biomembr (2009) 0.82

Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions. Int J Mol Med (2015) 0.82

Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons. PLoS One (2013) 0.80

Mitochondrial uncoupling protein 2 induces cell cycle arrest and necrotic cell death. Metab Syndr Relat Disord (2013) 0.79

Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function. PLoS One (2014) 0.79

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival. J Mol Neurosci (2016) 0.79

Sirt1: Role Under the Condition of Ischemia/Hypoxia. Cell Mol Neurobiol (2016) 0.78

Ischemic preconditioning enhances fatty acid-dependent mitochondrial uncoupling. J Bioenerg Biomembr (2007) 0.78

A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity. Age (Dordr) (2011) 0.76

Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci (2015) 0.75

Mitochondria and the regulation of free radical damage in the eye. J Ocul Biol Dis Infor (2009) 0.75

The emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury. Transl Neurosci (2015) 0.75

Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage. Orphanet J Rare Dis (2015) 0.75

Articles by these authors

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature (2011) 7.90

Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med (2006) 7.21

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet (2002) 6.02

Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (2004) 5.98

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol (2002) 4.60

Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44

Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25

Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest (2011) 4.17

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91

Parkinson's disease. Hum Mol Genet (2007) 3.84

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol (2003) 3.43

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol (2008) 3.35

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med (2009) 3.32

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23

Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09

Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron (2003) 2.80

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci U S A (2004) 2.77

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med (2008) 2.74

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72

An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity (2010) 2.71

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem (2002) 2.68

STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol (2009) 2.67

Neurobiology of feeding and energy expenditure. Annu Rev Neurosci (2007) 2.64

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci (2004) 2.57

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48

Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol (2009) 2.46

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J Biol Chem (2004) 2.43

Nicotine decreases food intake through activation of POMC neurons. Science (2011) 2.41

Modeling human cortical development in vitro using induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.41

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36

ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci (2002) 2.25

PEDF: a multifaceted neurotrophic factor. Nat Rev Neurosci (2003) 2.18

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell (2013) 2.11

Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease. Ann Neurol (2012) 2.08

Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med (2002) 2.08

Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci (2005) 2.06

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS Biol (2004) 2.02

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci (2002) 2.01

Maternal and offspring pools of osteocalcin influence brain development and functions. Cell (2013) 2.00

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99

Mitochondrial dysfunction and amyotrophic lateral sclerosis. Muscle Nerve (2006) 1.95

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93

Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci (2002) 1.92

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radic Biol Med (2010) 1.91

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp Neurol (2010) 1.91

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A (2009) 1.89

Measurements of ATP in mammalian cells. Methods (2002) 1.81

Impaired mitochondrial function in psychiatric disorders. Nat Rev Neurosci (2012) 1.80

Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci (2005) 1.79

The energetics of Huntington's disease. Neurochem Res (2004) 1.79

Oxidative damage in Huntington's disease pathogenesis. Antioxid Redox Signal (2006) 1.79

Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab (2009) 1.78

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int (2008) 1.76

Assay of mitochondrial ATP synthesis in animal cells and tissues. Methods Cell Biol (2007) 1.76

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet (2002) 1.75

Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev (2005) 1.75

Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73

Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology (2004) 1.70

Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci (2012) 1.68

Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci (2005) 1.67

Cross-talk between estrogen and leptin signaling in the hypothalamus. Am J Physiol Endocrinol Metab (2008) 1.67

Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci (2007) 1.66

Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab (2009) 1.66

Impaired PGC-1alpha function in muscle in Huntington's disease. Hum Mol Genet (2009) 1.63

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr Drug Targets CNS Neurol Disord (2005) 1.62

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Hum Mol Genet (2010) 1.62

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci (2008) 1.61

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A (2007) 1.58

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell (2008) 1.57

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57