Published in J Immunol on August 15, 2003
Protective immune mechanisms in helminth infection. Nat Rev Immunol (2007) 5.66
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Helminth-derived immunomodulators: can understanding the worm produce the pill? Nat Rev Immunol (2010) 1.66
Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies? Immunology (2009) 1.64
Parasitic worms and inflammatory diseases. Parasite Immunol (2006) 1.58
Helminth-host immunological interactions: prevention and control of immune-mediated diseases. Ann N Y Acad Sci (2012) 1.47
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Review series on helminths, immune modulation and the hygiene hypothesis: how might infection modulate the onset of type 1 diabetes? Immunology (2009) 1.22
Parasitic helminths: new weapons against immunological disorders. J Biomed Biotechnol (2010) 1.13
Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis. J Med Chem (2013) 1.13
Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice. Infect Immun (2009) 1.06
N-glycans of the porcine nematode parasite Ascaris suum are modified with phosphorylcholine and core fucose residues. FEBS J (2006) 1.01
The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clin Exp Immunol (2009) 1.01
Protective effect of an extract from Ascaris suum in experimental arthritis models. Infect Immun (2008) 0.99
Role of helminths in regulating mucosal inflammation. Springer Semin Immunopathol (2005) 0.97
Impact of Schistosoma japonicum infection on collagen-induced arthritis in DBA/1 mice: a murine model of human rheumatoid arthritis. PLoS One (2011) 0.96
The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates. PLoS One (2012) 0.95
ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints. Arthritis Rheumatol (2014) 0.93
Helminth infections decrease host susceptibility to immune-mediated diseases. J Immunol (2014) 0.93
The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. Int J Parasitol (2013) 0.93
Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications. BMC Med (2015) 0.93
Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients. Clin Exp Immunol (2006) 0.92
Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides. J Mol Endocrinol (2007) 0.92
Infection of non-encapsulated species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response. Parasitol Res (2010) 0.90
Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology (2005) 0.88
Helminths: Immunoregulation and Inflammatory Diseases-Which Side Are Trichinella spp. and Toxocara spp. on? J Parasitol Res (2013) 0.85
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. J Autoimmun (2015) 0.84
Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma. PLoS One (2012) 0.84
Autoimmunity and inflammation: murine models and translational studies. Mamm Genome (2011) 0.82
Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis. Clin Exp Immunol (2014) 0.81
Helminthes and insects: maladies or therapies. Parasitol Res (2014) 0.81
In vitro antigen presenting cell-derived IL-10 and IL-6 correlate with Trichuris muris isolate-specific survival. Parasite Immunol (2009) 0.81
Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology (2007) 0.80
Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease? PLoS Pathog (2016) 0.79
Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis. Clin Exp Immunol (2016) 0.79
Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice. Infect Immun (2008) 0.79
Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Exp Parasitol (2015) 0.79
Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells. Biochem J (2004) 0.78
The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol (2015) 0.77
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology (2004) 0.76
The Carbohydrate-linked Phosphorylcholine of the Parasitic Nematode Product ES-62 Modulates Complement Activation. J Biol Chem (2016) 0.76
Schistosoma japonicum HSP60-derived peptide SJMHE1 suppresses delayed-type hypersensitivity in a murine model. Parasit Vectors (2016) 0.76
Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Sci Rep (2017) 0.75
Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol (2016) 0.75
Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4+ Th-Cells. PLoS One (2016) 0.75
Filarial Abundant Larval Transcript Protein ALT-2: An Immunomodulatory Therapeutic Agent for Type 1 Diabetes. Indian J Clin Biochem (2016) 0.75
Kennedy Institute of Rheumatology Division, Imperial College London, 12-13 November 2003: towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis. Arthritis Res Ther (2004) 0.75
Somatic antigens of tropical liver flukes ameliorate collagen-induced arthritis in wistar rats. PLoS One (2015) 0.75
Immuno-Modulatory Effect and Therapeutic Potential of Brugia malayi Cystatin in Experimentally Induced Arthritis. Indian J Clin Biochem (2015) 0.75
The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis. Inflamm Cell Signal (2015) 0.75
Human schistosome infection and allergic sensitisation. J Parasitol Res (2012) 0.75
Helminth Immunomodulation in Autoimmune Disease. Front Immunol (2017) 0.75
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 3.70
IL-33 reduces the development of atherosclerosis. J Exp Med (2008) 3.59
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol (2009) 3.41
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A (2011) 3.37
IL-33, a potent inducer of adaptive immunity to intestinal nematodes. J Immunol (2008) 3.31
Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol (2002) 3.30
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol (2004) 3.19
The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites. Arthritis Rheum (2012) 3.16
TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A (2004) 3.04
IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc Natl Acad Sci U S A (2008) 2.99
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol (2008) 2.83
IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol (2007) 2.82
Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nat Med (2007) 2.53
IL-33 is a chemoattractant for human Th2 cells. Eur J Immunol (2007) 2.43
Retracted The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88. Nat Immunol (2011) 2.41
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med (2010) 2.38
Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum (2005) 2.37
A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol (2003) 2.37
CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol (2003) 2.19
Retracted The cytokine interleukin-33 mediates anaphylactic shock. Proc Natl Acad Sci U S A (2009) 2.15
CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol (2003) 2.11
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol (2004) 1.88
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circ Res (2010) 1.80
IL-33 exacerbates eosinophil-mediated airway inflammation. J Immunol (2010) 1.73
IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol (2011) 1.72
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci U S A (2008) 1.67
Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter. Am J Respir Crit Care Med (2004) 1.64
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy. Ann Rheum Dis (2010) 1.62
Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol (2005) 1.61
Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome. BMC Immunol (2005) 1.61
Animal models of rheumatoid arthritis. Eur J Immunol (2009) 1.57
A novel therapy of murine collagen-induced arthritis with soluble T1/ST2. J Immunol (2004) 1.55
Type 2 innate lymphoid cells drive CD4+ Th2 cell responses. J Immunol (2014) 1.48
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol (2004) 1.46
Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A (2007) 1.45
IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. Eur J Immunol (2012) 1.43
TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J Immunol (2005) 1.41
Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr Opin Pharmacol (2004) 1.41
IL-33 exacerbates autoantibody-induced arthritis. J Immunol (2010) 1.40
CXCR2-specific chemokines mediate leukotriene B4-dependent recruitment of neutrophils to inflamed joints in mice with antigen-induced arthritis. Arthritis Rheum (2008) 1.39
IL-33 reduces macrophage foam cell formation. J Immunol (2010) 1.32
Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Proc Natl Acad Sci U S A (2002) 1.31
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A (2009) 1.31
The IL-33/ST2 pathway--A new therapeutic target in cardiovascular disease. Pharmacol Ther (2011) 1.28
Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis. J Immunol (2009) 1.28
Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res Ther (2006) 1.27
IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4. J Immunol (2003) 1.26
Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J Immunol (2002) 1.23
Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology (2003) 1.23
A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation. J Immunol (2002) 1.22
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol (2008) 1.22
Interleukin-33 and the function of innate lymphoid cells. Trends Immunol (2012) 1.20
A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am J Respir Crit Care Med (2009) 1.19
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol (2005) 1.18
Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One (2011) 1.18
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. J Immunol (2009) 1.16
Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. J Immunol (2008) 1.16
Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A (2011) 1.14
Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis. J Med Chem (2013) 1.13
Immunological characterization of the spike protein of the severe acute respiratory syndrome coronavirus. J Clin Microbiol (2004) 1.13
IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro. Eur J Immunol (2002) 1.13
Retracted Expression and function of Toll-like receptor on T cells. Cell Immunol (2005) 1.12
IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss. J Immunol (2011) 1.12
IL-33 induces skin inflammation with mast cell and neutrophil activation. Eur J Immunol (2011) 1.11
Cytokine networks--towards new therapies for rheumatoid arthritis. Nat Clin Pract Rheumatol (2005) 1.11
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. Am J Respir Crit Care Med (2004) 1.11
IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J Immunol (2006) 1.08
The role of sphingosine kinase in a murine model of allergic asthma. J Immunol (2008) 1.08
Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. Eur J Immunol (2005) 1.08
SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol (2010) 1.08
Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis Rheum (2007) 1.08
IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. Eur J Immunol (2007) 1.06
Hsp90 is essential in the filarial nematode Brugia pahangi. Int J Parasitol (2005) 1.05
Glycogen synthase kinase-3beta inhibition attenuates asthma in mice. Am J Respir Crit Care Med (2007) 1.05
Retracted Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. J Cell Physiol (2006) 1.04
ST2, an IL-1R family member, attenuates inflammation and lethality after intestinal ischemia and reperfusion. J Leukoc Biol (2006) 1.03
IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis. J Clin Invest (2002) 1.03
Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response. J Exp Med (2002) 1.02
Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Behav Immun (2006) 1.02
IL-33 activates B1 cells and exacerbates contact sensitivity. J Immunol (2011) 1.01
Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. J Immunol (2008) 0.99
IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol (2007) 0.98
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin. J Allergy Clin Immunol (2012) 0.98
Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis (2011) 0.98
Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. J Immunol (2008) 0.97
A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes. Blood (2003) 0.97
CD4+CD25+ regulatory T cells in health and disease. Clin Exp Pharmacol Physiol (2006) 0.96
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. Eur J Pharmacol (2012) 0.95
Chemoattraction of human T cells by IL-18. J Immunol (2003) 0.95