1
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Immunity
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2009
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2.51
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2
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Vitamin D receptor-deficient mice fail to develop experimental allergic asthma.
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J Immunol
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2004
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2.31
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3
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Actin depolymerization transduces the strength of B-cell receptor stimulation.
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Mol Biol Cell
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1.62
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4
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Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma.
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J Exp Med
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1.59
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1.46
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6
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Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK.
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J Immunol
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2003
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1.41
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7
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Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
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2009
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1.35
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8
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Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development.
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J Immunol
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2008
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1.32
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9
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Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses.
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J Virol
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2007
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1.27
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10
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Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation.
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Arch Biochem Biophys
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2007
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1.19
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11
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Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
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J Immunol
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2008
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1.11
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12
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Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase.
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J Allergy Clin Immunol
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2006
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1.08
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13
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Natural killer T cells: rapid responders controlling immunity and disease.
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Int J Biochem Cell Biol
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2005
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1.07
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14
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A Polymerase mechanism-based strategy for viral attenuation and vaccine development.
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J Biol Chem
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2012
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1.06
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15
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Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.
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J Biol Chem
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2004
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1.06
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16
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Selective targeting of ITK blocks multiple steps of HIV replication.
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Proc Natl Acad Sci U S A
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2008
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1.04
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17
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Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma.
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Arch Biochem Biophys
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2003
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1.03
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18
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Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.
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J Biol Chem
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2011
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1.03
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Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo.
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J Am Chem Soc
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2007
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1.00
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20
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Chemico-genetic identification of drebrin as a regulator of calcium responses.
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Int J Biochem Cell Biol
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2009
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0.99
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21
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Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
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Sci STKE
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2007
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0.98
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22
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Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.
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J Biol Chem
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2006
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0.98
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23
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Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway.
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2003
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0.97
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24
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Expression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells.
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J Cell Biochem
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2009
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0.97
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25
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Computational and experimental analysis reveals a requirement for eosinophil-derived IL-13 for the development of allergic airway responses in C57BL/6 mice.
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J Immunol
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2011
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0.96
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26
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The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.
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J Immunol
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2008
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0.94
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27
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Eosinophils and allergic airway disease: there is more to the story.
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Trends Immunol
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2009
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0.94
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28
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Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.
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Int Immunol
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2008
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0.92
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A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation.
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FEBS Lett
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2006
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0.92
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30
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CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation.
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Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.
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Int J Biochem Cell Biol
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Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells.
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The role of eosinophils in allergic airway inflammation.
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Discov Med
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Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration.
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J Immunol
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Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk.
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PLoS One
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A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.
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BMC Cell Biol
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2002
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37
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Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.
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J Immunol
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IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.
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ITK inhibitors in inflammation and immune-mediated disorders.
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Cutting edge: innate memory CD8+ T cells are distinct from homeostatic expanded CD8+ T cells and rapidly respond to primary antigenic stimuli.
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J Immunol
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The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.
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J Immunol
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42
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p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly.
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Am J Physiol Cell Physiol
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43
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Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells.
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J Biol Chem
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A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
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Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.
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Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
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Biochem J
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A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation.
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BMC Immunol
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48
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The Tec family kinase Itk exists as a folded monomer in vivo.
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J Biol Chem
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Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults.
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Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ(12)-prostaglandin J3.
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Differential regulation of cytokine production by CD1d-restricted NKT cells in response to superantigen staphylococcal enterotoxin B exposure.
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Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.
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Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk.
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The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor.
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Editorial: Jack of all trades? The versatility of IL-4 in CD8+ T cell polarity.
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Modulation of tracheal smooth muscle responses in inducible T-cell kinase knockout mice.
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hCMV IE Promoter is responsive to B cell receptor signaling in a Bruton's tyrosine kinase dependent manner: caution in their use as internal controls.
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