Published in Proc Natl Acad Sci U S A on April 28, 2008
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SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci U S A (2007) 1.30
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Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol (2004) 1.17
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A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (2011) 5.72
SAP-controlled T-B cell interactions underlie germinal centre formation. Nature (2008) 5.14
Follicular helper T cells are required for systemic autoimmunity. J Exp Med (2009) 4.25
SAP is required for generating long-term humoral immunity. Nature (2003) 3.85
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science (2011) 3.49
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity (2011) 3.06
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
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A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
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Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity (2006) 2.77
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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59
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SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol (2011) 2.52
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity (2009) 2.51
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A (2014) 2.50
Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell (2010) 2.43
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J Exp Med (2009) 2.34
Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol (2004) 2.31
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity (2012) 2.19
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology (2008) 2.03
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol (2003) 1.92
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Biochemistry (2008) 1.82
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J Med Chem (2008) 1.81
Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media. Genesis (2004) 1.79
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood (2010) 1.77
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem (2006) 1.71
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc Natl Acad Sci U S A (2010) 1.64
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest (2004) 1.63
Actin depolymerization transduces the strength of B-cell receptor stimulation. Mol Biol Cell (2005) 1.62
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem (2010) 1.61
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61
Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. J Exp Med (2008) 1.59
Requirements for selection of conventional and innate T lymphocyte lineages. Immunity (2007) 1.59
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis (2008) 1.58
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol Rev (2005) 1.57
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol (2005) 1.54
SH2D1A regulates T-dependent humoral autoimmunity. J Exp Med (2004) 1.51
Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex. J Biol Chem (2007) 1.51
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol (2003) 1.47
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab (2015) 1.46
Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol (2007) 1.46
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Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem (2010) 1.45
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol (2003) 1.41
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40
Function of small hydrophobic proteins of paramyxovirus. J Virol (2006) 1.39
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem (2006) 1.38
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett (2010) 1.37
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production. Blood (2009) 1.35
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem (2009) 1.34
Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development. J Immunol (2008) 1.32
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev (2009) 1.32
Phosphatidylserine on HIV envelope is a cofactor for infection of monocytic cells. J Immunol (2003) 1.31
Tuning the optical properties of fluorinated indolylfulgimides. J Org Chem (2003) 1.29
Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol (2006) 1.29
Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. J Virol (2007) 1.27
Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Exp Cell Res (2006) 1.26
Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition. J Med Chem (2007) 1.26
Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. J Biomol Screen (2008) 1.25
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem (2011) 1.24
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem (2005) 1.21
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A (2006) 1.21
A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists. J Am Chem Soc (2008) 1.20
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity (2012) 1.20
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology (2010) 1.20
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008. J Comb Chem (2009) 1.19
Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Arch Biochem Biophys (2007) 1.19
SAP is required for Th cell function and for immunity to influenza. J Immunol (2006) 1.18
Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol (2004) 1.17
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med (2014) 1.16
T follicular helper cell diversity and plasticity. Trends Immunol (2013) 1.14
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood (2010) 1.14
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.13
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci U S A (2010) 1.13