Published in Mol Microbiol on September 01, 2003
Diversity of microbial sialic acid metabolism. Microbiol Mol Biol Rev (2004) 3.11
Colloquium paper: uniquely human evolution of sialic acid genetics and biology. Proc Natl Acad Sci U S A (2010) 2.30
Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci (2012) 2.09
Siglecs as targets for therapy in immune-cell-mediated disease. Trends Pharmacol Sci (2009) 2.04
Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood (2005) 1.94
Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci U S A (2004) 1.93
Pathogenic neisseriae: surface modulation, pathogenesis and infection control. Nat Rev Microbiol (2009) 1.87
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol (2007) 1.84
Siglecs and immune regulation. Annu Rev Immunol (2012) 1.81
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol (2006) 1.57
Basic and clinical immunology of Siglecs. Ann N Y Acad Sci (2008) 1.56
Multiple changes in sialic acid biology during human evolution. Glycoconj J (2008) 1.43
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med (2009) 1.34
Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides. Infect Immun (2006) 1.34
Cellular and molecular biology of Neisseria meningitidis colonization and invasive disease. Clin Sci (Lond) (2010) 1.31
Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol (2006) 1.29
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol (2009) 1.21
Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol (2012) 1.14
Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides. Infect Immun (2010) 1.13
Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. PLoS Pathog (2009) 1.12
Siglecs as sensors of self in innate and adaptive immune responses. Ann N Y Acad Sci (2012) 1.08
Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Lett (2009) 1.08
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. PLoS One (2011) 1.08
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci U S A (2012) 1.06
Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner. Infect Immun (2011) 1.06
Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays. Glycoconj J (2007) 1.06
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem (2007) 1.06
Sialoadhesin in recognition of self and non-self. Semin Immunopathol (2012) 1.05
Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169. PLoS One (2012) 1.04
Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation. Immunology (2013) 1.02
The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review. Int J Inflam (2010) 0.99
Increased association of Trypanosoma cruzi with sialoadhesin positive mice macrophages. Parasitol Res (2005) 0.98
The interplay between Siglecs and sialylated pathogens. Glycobiology (2014) 0.96
Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells. Cell Microbiol (2012) 0.95
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci (2013) 0.94
Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis. Glycoconj J (2009) 0.91
Dendritic cells: a spot on sialic Acid. Front Immunol (2013) 0.91
O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J (2010) 0.91
Mutational analysis of human CEACAM1: the potential of receptor polymorphism in increasing host susceptibility to bacterial infection. Cell Microbiol (2006) 0.91
Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E. J Biol Chem (2011) 0.90
Targeting to porcine sialoadhesin receptor improves antigen presentation to T cells. Vet Res (2008) 0.88
Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cell Immunol (2008) 0.87
Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5. Haematologica (2012) 0.86
Sialylation of Campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice. PLoS One (2012) 0.85
Porcine sialoadhesin: a newly identified xenogeneic innate immune receptor. Am J Transplant (2012) 0.85
Genomic and metabolic profiling of nonulosonic acids in Vibrionaceae reveal biochemical phenotypes of allelic divergence in Vibrio vulnificus. Appl Environ Microbiol (2011) 0.85
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. J Biol Chem (2011) 0.84
Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. PLoS One (2012) 0.84
Multivalent ligands for siglecs. Methods Enzymol (2010) 0.83
Ubiquitous sialometabolism present among oral fusobacteria. PLoS One (2014) 0.82
Refolded recombinant Siglec5 for NMR investigation of complex carbohydrate binding. Protein Expr Purif (2013) 0.81
LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A. Cell Microbiol (2013) 0.81
Expression of sialic acids and other nonulosonic acids in Leptospira. BMC Microbiol (2012) 0.80
Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med (Berl) (2014) 0.80
Sialylation of lipooligosaccharides is dispensable for the virulence of Haemophilus ducreyi in humans. Infect Immun (2011) 0.79
Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages. Retrovirology (2013) 0.78
Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus. Vet Res (2016) 0.78
Enhanced, sialoadhesin-dependent uptake of Guillain-Barre syndrome-associated Campylobacter jejuni strains by human macrophages. Infect Immun (2013) 0.77
Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-β1 Production. J Biol Chem (2016) 0.77
The biology of Neisseria adhesins. Biology (Basel) (2013) 0.77
Sialic acids siglec interaction: a unique strategy to circumvent innate immune response by pathogens. Indian J Med Res (2013) 0.76
Role of secondary lymphoid tissues in primary and memory T-cell responses to a transplanted organ. Transplant Rev (Orlando) (2009) 0.75
Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep (2016) 0.75
Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol (2016) 0.75
Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice. Hum Mol Genet (2017) 0.75
Enhanced lentiviral vector production in 293FT cells expressing Siglec-9. Cytotechnology (2014) 0.75
Influence of ageing on the microarchitecture of the spleen and lymph nodes. Biogerontology (2017) 0.75
Chronic Brucella infection induces selective and persistent IFN-γ-dependent alterations of marginal zone macrophages in the spleen. Infect Immun (2017) 0.75
The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils. Eur J Immunol (2004) 2.38
In vivo targeting of B-cell lymphoma with glycan ligands of CD22. Blood (2010) 2.17
Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J (2009) 2.12
Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis X as a preferred glycan ligand. Glycobiology (2005) 2.06
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol (2007) 1.84
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood (2006) 1.76
Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein. J Biol Chem (2003) 1.68
Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili. Proc Natl Acad Sci U S A (2004) 1.52
A novel cell-binding mechanism of Moraxella catarrhalis ubiquitous surface protein UspA: specific targeting of the N-domain of carcinoembryonic antigen-related cell adhesion molecules by UspA1. Mol Microbiol (2003) 1.50
Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol (2007) 1.48
Neoglycolipid probes prepared via oxime ligation for microarray analysis of oligosaccharide-protein interactions. Chem Biol (2007) 1.42
Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? Immunology (2010) 1.37
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. Eur J Immunol (2003) 1.35
Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol (2007) 1.34
Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides. Infect Immun (2006) 1.34
Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. J Allergy Clin Immunol (2007) 1.32
Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin. Structure (2003) 1.32
Cellular and molecular biology of Neisseria meningitidis colonization and invasive disease. Clin Sci (Lond) (2010) 1.31
Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol (2006) 1.29
Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production. J Immunol (2009) 1.23
A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9. J Biol Chem (2001) 1.22
Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection. Int Immunol (2007) 1.22
The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog (2010) 1.22
CD169 mediates the capture of exosomes in spleen and lymph node. Blood (2013) 1.20
Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J Biol Chem (2002) 1.20
Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis. J Immunol (2006) 1.20
Meningococcal interactions with the host. Vaccine (2009) 1.17
SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses. J Biol Chem (2006) 1.16
Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells. Immunobiology (2004) 1.16
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression. J Immunol (2009) 1.16
Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem (2005) 1.16
Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol (2012) 1.14
Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling. Blood (2013) 1.13
The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil. EMBO J (2008) 1.13
Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides. Infect Immun (2010) 1.13
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. J Biol Chem (2002) 1.12
Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x. J Pharmacol Exp Ther (2009) 1.12
Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate. Blood (2009) 1.10
Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b. J Biol Chem (2006) 1.09
MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Res (2007) 1.09
Genetic and functional analysis of the phosphorylcholine moiety of commensal Neisseria lipopolysaccharide. Mol Microbiol (2002) 1.09
A versatile gold surface approach for fabrication and interrogation of glycoarrays. Chembiochem (2008) 1.08
Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Lett (2009) 1.08
Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays. Glycobiology (2009) 1.06
Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner. Infect Immun (2011) 1.06
Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays. Glycoconj J (2007) 1.06
Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidis. J Biol Chem (2005) 1.05
Sialoadhesin in recognition of self and non-self. Semin Immunopathol (2012) 1.05
Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169. PLoS One (2012) 1.04
Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. PLoS Pathog (2010) 1.04
The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. Biochem J (2006) 1.02
Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance. Mol Microbiol (2011) 1.01
Carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-binding recombinant polypeptide confers protection against infection by respiratory and urogenital pathogens. Mol Microbiol (2005) 1.01
Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice. Neurobiol Dis (2006) 1.01
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem (2013) 0.99
The antigen recognized by MOMA-I is sialoadhesin. Immunol Lett (2006) 0.98
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci U S A (2013) 0.97
Carbohydrate microarrays reveal sulphation as a modulator of siglec binding. Biochem Biophys Res Commun (2006) 0.97
Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidis. Cell Microbiol (2006) 0.97
Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine. Inflamm Bowel Dis (2008) 0.95
Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo. Glycobiology (2002) 0.95
Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells. Infect Immun (2009) 0.94
Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin. Cell Microbiol (2008) 0.93
IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1. Cell Microbiol (2007) 0.93
Critical determinants of the interactions of capsule-expressing Neisseria meningitidis with host cells: the role of receptor density in increased cellular targeting via the outer membrane Opa proteins. Cell Microbiol (2005) 0.92
Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin. J Mol Biol (2006) 0.92
Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1. J Biol Chem (2004) 0.92
Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression. J Clin Immunol (2011) 0.92
Plasmacytoid dendritic cells do not migrate in intestinal or hepatic lymph. J Immunol (2006) 0.91
Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies. Proc Natl Acad Sci U S A (2014) 0.91
Mutational analysis of human CEACAM1: the potential of receptor polymorphism in increasing host susceptibility to bacterial infection. Cell Microbiol (2006) 0.91
CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease. Carbohydr Res (2008) 0.91
Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E. J Biol Chem (2011) 0.90
Involvement of the autophagy pathway in trafficking of Mycobacterium tuberculosis bacilli through cultured human type II epithelial cells. Cell Microbiol (2012) 0.87
Differential expression of beta-galactoside alpha2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma. Lab Invest (2002) 0.87
Enhancing the receptor affinity of the sialic acid-binding domain of Vibrio cholerae sialidase through multivalency. J Biol Chem (2009) 0.87
Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cell Immunol (2008) 0.87
Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes. Glycobiology (2002) 0.86
Analysis of sialoadhesin expression on mouse alveolar macrophages. Immunol Lett (2009) 0.83
Complex of sialoadhesin with a glycopeptide ligand. Biochim Biophys Acta (2004) 0.81
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proc Natl Acad Sci U S A (2011) 0.81
A novel group of Moraxella catarrhalis UspA proteins mediates cellular adhesion via CEACAMs and vitronectin. PLoS One (2012) 0.81
Glycoimmunology: ignore at your peril! Immunol Rev (2009) 0.81
Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169). Immunology (2014) 0.80
Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice. Arthritis Res Ther (2013) 0.80
Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. J Immunol (2013) 0.80
Meningococcal ligands and molecular targets of the host. Methods Mol Biol (2012) 0.80
Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med (Berl) (2014) 0.80
An expression system for screening of proteins for glycan and protein interactions. Anal Biochem (2011) 0.80
Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci (2008) 0.79
Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion. Chem Commun (Camb) (2011) 0.78
RETRACTED: Sialic acids, important constituents and selective recognition factors of Pseudomonas aeruginosa, an opportunistic pathogen. Infect Immun (2009) 0.78
PEGylation of anti-sialoadhesin monoclonal antibodies enhances their inhibitory potencies without impairing endocytosis in mouse peritoneal macrophages. Bioconjug Chem (2009) 0.76
Limited sampling strategy for cyclosporine (Neoral) area under the curve monitoring in pediatric kidney transplant recipients. Pediatr Transplant (2005) 0.76
The inhibitory potencies of monoclonal antibodies to the macrophage adhesion molecule sialoadhesin are greatly increased following PEGylation. Bioconjug Chem (2008) 0.75
Visualisation and quantification of intracellular interactions of Neisseria meningitidis and human α-actinin by confocal imaging. J Vis Exp (2010) 0.75