Published in Cancer Res on August 15, 2003
Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res (2005) 2.59
Organ selectivity in metastasis: regulation by chemokines and their receptors. Clin Exp Metastasis (2007) 2.18
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal (2008) 1.81
High-level CXCR4 expression correlates with brain-specific metastasis of non-small cell lung cancer. World J Surg (2011) 1.58
Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev (2007) 1.49
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer (2006) 1.48
Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Res (2007) 1.28
pHUSH: a single vector system for conditional gene expression. BMC Biotechnol (2007) 1.27
CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. Neoplasia (2009) 1.21
The role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis. Int J Cell Biol (2012) 1.15
Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis (2008) 1.14
Optimizing RNA interference for application in mammalian cells. Biochem J (2004) 1.09
Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. Breast Cancer Res (2010) 1.03
Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines. Nucleic Acids Res (2007) 1.01
A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget (2014) 1.00
Lentiviral vectors encoding tetracycline-dependent repressors and transactivators for reversible knockdown of gene expression: a comparative study. BMC Biotechnol (2007) 1.00
MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias. Blood Cancer J (2011) 1.00
CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model. PLoS One (2012) 0.98
Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther (2012) 0.97
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. J Mol Biol (2006) 0.96
Chemokines: key players in cancer progression and metastasis. Front Biosci (Schol Ed) (2011) 0.94
Perineural growth in head and neck squamous cell carcinoma: a review. Oral Oncol (2014) 0.92
A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA (2007) 0.92
Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing, estrogen receptor-positive breast cancer cells. Breast Cancer Res Treat (2008) 0.91
SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB. J Biol Chem (2008) 0.90
Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors. Semin Cancer Biol (2008) 0.90
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. Sci Rep (2014) 0.87
A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem. Biochim Biophys Acta (2008) 0.86
Generation of RNAi libraries for high-throughput screens. J Biomed Biotechnol (2006) 0.86
Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. Ophthalmology (2006) 0.85
An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. J Biol Chem (2013) 0.85
Establishment of CXCR4-small interfering RNA retrovirus vector driven by human prostate-specific antigen promoter and its biological effects on prostate cancer in vitro and in vivo. J Cancer Res Clin Oncol (2008) 0.84
CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells. Cancer Lett (2011) 0.82
The CXCL12 G801A polymorphism is associated with cancer risk: a meta-analysis. PLoS One (2014) 0.81
Tetracycline regulated systems in functional oncogenomics. Transl Oncogenomics (2007) 0.79
RNAi and cancer: Implications and applications. J RNAi Gene Silencing (2006) 0.77
Phenotypic Knockout of CXCR4 Expression by a Novel Intrakine Mutant hSDF-1α/54/KDEL Inhibits Breast Cancer Metastasis. J Interferon Cytokine Res (2015) 0.76
Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line. Exp Ther Med (2016) 0.75
New approaches for cancer treatment: antitumor drugs based on gene-targeted nucleic acids. Acta Naturae (2009) 0.75
The Effects of Tamoxifen in Combination with Tranilast on CXCL12-CXCR4 Axis and Invasion in Breast Cancer Cell Lines. Iran J Pharm Res (2014) 0.75
Effect of DcR3-specific siRNA on cell growth suppression and apoptosis induction in glioma cells via affecting ERK and AKT. Onco Targets Ther (2016) 0.75
CXCL12/CXCR4 axis induces proliferation and invasion in human endometrial cancer. Am J Transl Res (2016) 0.75
Immunoglobulin superfamily genes are novel prognostic biomarkers for breast cancer. Oncotarget (2016) 0.75
Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol (2016) 0.75
Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device. PLoS One (2017) 0.75
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
Locus control regions. Blood (2002) 4.41
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood (2007) 3.05
Thalassaemia. Lancet (2011) 1.89
MicroRNA expression dynamics during murine and human erythroid differentiation. Exp Hematol (2007) 1.67
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects. Hum Gene Ther (2007) 1.55
Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J Biol Chem (2001) 1.41
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood (2002) 1.41
Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood (2004) 1.34
Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo. Blood (2002) 1.30
Induction of human gamma globin gene expression by histone deacetylase inhibitors. Blood (2003) 1.23
Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors. Mol Ther (2002) 1.19
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther (2009) 1.13
Genome architecture of the human beta-globin locus affects developmental regulation of gene expression. Mol Cell Biol (2005) 1.09
Evidence that DNase I hypersensitive site 5 of the human beta-globin locus control region functions as a chromosomal insulator in transgenic mice. Nucleic Acids Res (2002) 1.09
Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture. Mol Cell Biol (2005) 1.04
Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene. Proc Natl Acad Sci U S A (2002) 1.03
Histone acetylation at the human beta-globin locus changes with developmental age. Blood (2007) 1.03
KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke. Brain (2013) 1.01
Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression. Exp Hematol (2003) 0.98
Functional study of transcription factor KLF11 by targeted gene inactivation. Blood Cells Mol Dis (2004) 0.96
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. J Mol Biol (2006) 0.96
Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR. J Mol Biol (2006) 0.95
Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity. J Mol Biol (2003) 0.94
Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major. Hum Gene Ther (2013) 0.93
Transgenic Cre expression mice for generation of erythroid-specific gene alterations. Genesis (2004) 0.93
Gene therapy for β-thalassaemia: the continuing challenge. Expert Rev Mol Med (2010) 0.92
The minimal promoter plays a major role in silencing of the galago gamma-globin gene in adult erythropoiesis. Proc Natl Acad Sci U S A (2004) 0.92
Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. J Biol Chem (2003) 0.91
Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway. Arterioscler Thromb Vasc Biol (2012) 0.89
Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region. Hum Mol Genet (2002) 0.88
Hematopoietic stem cell gene therapy. Int J Hematol (2002) 0.88
A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells. J Virol (2002) 0.87
A European population in Minoan Bronze Age Crete. Nat Commun (2013) 0.87
The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis. J Cell Biochem (2007) 0.85
The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. Blood Cells Mol Dis (2003) 0.85
Induction of fetal hemoglobin by propionic and butyric acid derivatives: correlations between chemical structure and potency of Hb F induction. Blood Cells Mol Dis (2002) 0.84
Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin. Am J Hematol (2006) 0.84
Transcriptional potentials of the beta-like globin genes at different developmental stages in transgenic mice and hemoglobin switching. Blood Cells Mol Dis (2004) 0.84
Investigations of a human embryonic globin gene silencing element using YAC transgenic mice. Exp Biol Med (Maywood) (2006) 0.83
Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection. Mol Ther (2006) 0.83
Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo. Exp Hematol (2005) 0.82
Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes. Hum Mol Genet (2003) 0.82
Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites. Hum Gene Ther (2011) 0.82
The higher structure of chromatin in the LCR of the beta-globin locus changes during development. J Mol Biol (2009) 0.81
Selection with a regulated cell growth switch increases the likelihood of expression for a linked gamma-globin gene. Blood Cells Mol Dis (2005) 0.81
Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells. Biochim Biophys Acta (2005) 0.80
Autonomous silencing as well as competition controls gamma-globin gene expression during development. Mol Cell Biol (2006) 0.80
A search for β thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans. Blood Cells Mol Dis (2011) 0.79
Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model. Hum Gene Ther Methods (2014) 0.79
Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors. BMC Genomics (2013) 0.79
Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease. Ann N Y Acad Sci (2010) 0.79
Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner. Nucleic Acids Res (2006) 0.79
Differences of globin transgene expression in stably transfected cell lines and transgenic mice. Blood (2004) 0.78
The use of in vitro transcription to probe regulatory functions of viral protein domains. Methods Mol Med (2007) 0.78
Effects of human gamma-globin in murine beta-thalassaemia. Br J Haematol (2006) 0.78
Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter. J Biol Chem (2006) 0.78
Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis. Hum Mol Genet (2005) 0.78
Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching. J Cell Biochem (2007) 0.77
Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif. Biochem J (2004) 0.77
Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model. Blood Cells Mol Dis (2009) 0.77
Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains. Biochem Biophys Res Commun (2002) 0.77
Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region. Hum Gene Ther (2008) 0.76
Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny. Exp Hematol (2013) 0.75
Investigations of the induction of the goat beta(C) globin gene by erythropoietin: studies in transgenic mice. Blood Cells Mol Dis (2005) 0.75