Published in Org Biomol Chem on June 21, 2003
Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. J Am Chem Soc (2009) 2.35
Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives. J Am Chem Soc (2010) 1.58
Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues. Bioorg Med Chem Lett (2010) 1.32
10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids. ACS Med Chem Lett (2011) 1.27
Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign. J Med Chem (2013) 1.10
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Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent. Bioorg Med Chem Lett (2017) 0.77
Ring-expansion synthesis and crystal structure of dimethyl 4-ethyl-1,4,5,6,7,8-hexa-hydro-azonino[5,6-b]indole-2,3-di-carboxyl-ate. Acta Crystallogr E Crystallogr Commun (2017) 0.75
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19
Allosteric activators of glucokinase: potential role in diabetes therapy. Science (2003) 3.97
Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family. Biochemistry (2010) 3.70
Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components. Proc Natl Acad Sci U S A (2011) 3.59
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell (2011) 3.49
Structure of the agonist-bound neurotensin receptor. Nature (2012) 3.23
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (2011) 3.05
Self-powered nanowire devices. Nat Nanotechnol (2010) 2.98
Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev (2012) 2.82
Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (2008) 2.79
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast. Genes Dev (2006) 2.73
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem (2004) 2.45
Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A (2003) 2.44
Oxidoreductive cellulose depolymerization by the enzymes cellobiose dehydrogenase and glycoside hydrolase 61. Appl Environ Microbiol (2011) 2.43
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst (2008) 2.21
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res (2006) 2.15
Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain (2009) 2.05
Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res (2010) 2.05
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A (2005) 2.03
Associations between hospital and surgeon procedure volumes and patient outcomes after ovarian cancer resection. J Natl Cancer Inst (2006) 2.01
Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol (2008) 2.00
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc Natl Acad Sci U S A (2007) 1.92
Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magn Reson Med (2010) 1.91
Engineering hydrogels as extracellular matrix mimics. Nanomedicine (Lond) (2010) 1.86
Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro. Circ Res (2006) 1.84
Establishment of transcriptional competence in early and late S phase. Nature (2002) 1.81
Should FEV1/FEV6 replace FEV1/FVC ratio to detect airway obstruction? A metaanalysis. Chest (2009) 1.80
Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One (2010) 1.78
AtPID: Arabidopsis thaliana protein interactome database--an integrative platform for plant systems biology. Nucleic Acids Res (2007) 1.76
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proc Natl Acad Sci U S A (2006) 1.71
Greatly increased toughness of infiltrated spider silk. Science (2009) 1.71
Cystectomy for muscle-invasive bladder cancer: patterns and outcomes of care in the Medicare population. Urology (2005) 1.69
Advances in developing HIV-1 viral load assays for resource-limited settings. Biotechnol Adv (2010) 1.65
Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex (2010) 1.63
Antiemetic placebo: reduce adverse drug interactions between chemotherapeutic agents and antiemetic drugs in cancer patients. Med Hypotheses (2007) 1.62
Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. Am J Pathol (2005) 1.61
Power generation with laterally packaged piezoelectric fine wires. Nat Nanotechnol (2008) 1.58
Risk factors for intrahepatic cholangiocarcinoma: a case-control study in China. World J Gastroenterol (2008) 1.58
Obesity-related glomerulopathy: body mass index and proteinuria. Clin J Am Soc Nephrol (2010) 1.54
miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int J Cancer (2011) 1.53
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem (2012) 1.53
Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock. Shock (2013) 1.51
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol (2003) 1.50
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci (2007) 1.50
Chinese pharmacists propose patient consent for unlabeled use of medications. J Manag Care Pharm (2010) 1.49
Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells. Tumour Biol (2012) 1.47
Glycemic variability in gestational diabetes mellitus and its association with β cell function. Endocrine (2012) 1.46
Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. Tissue Eng Part C Methods (2010) 1.46
Combined hepatocellular carcinoma and cholangiocarcinoma: a case report and review of the literature. Hepatobiliary Pancreat Dis Int (2007) 1.42
Quantitative analysis of hemoglobin content in polymeric nanoparticles as blood substitutes using Fourier transform infrared spectroscopy. J Mater Sci Mater Med (2010) 1.41
Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. Clin Cancer Res (2009) 1.40
Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med (2011) 1.40
A novel method of naturally contouring the reconstructed ear: modified antihelix complex affixed to grooved base frame. Plast Reconstr Surg (2014) 1.39
Diagnosis and Management of 60 Children with Congenital Vascular Rings: A 10-year Experience. Chin Med J (Engl) (2015) 1.39
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res (2010) 1.36
Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation (2013) 1.35
The clinical feasibility and effect of online cone beam computer tomography-guided intensity-modulated radiotherapy for nasopharyngeal cancer. Radiother Oncol (2008) 1.35
Converting biomechanical energy into electricity by a muscle-movement-driven nanogenerator. Nano Lett (2009) 1.35
Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials (2009) 1.35
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res (2002) 1.34
Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther (2009) 1.33
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood (2011) 1.32
A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult chinese patients. Am J Kidney Dis (2012) 1.32
Clinical features of solitary necrotic nodule of the liver. Hepatobiliary Pancreat Dis Int (2008) 1.32
In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging. Laboratory investigation. J Neurosurg (2008) 1.32
Retroperitoneal ganglioneuroma in children: CT and MRI features with histologic correlation. Eur J Radiol (2010) 1.31
Therapeutic target database update 2014: a resource for targeted therapeutics. Nucleic Acids Res (2013) 1.31
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A (2006) 1.30
Fragmentation of care for frequently hospitalized urban residents. Med Care (2006) 1.29
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29
A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood (2004) 1.29
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. Cancer Res (2010) 1.26
Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing. Biotechnol J (2011) 1.25
STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res (2011) 1.24
Vitrification and levitation of a liquid droplet on liquid nitrogen. Proc Natl Acad Sci U S A (2010) 1.24
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab (2013) 1.22
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. Hepatobiliary Pancreat Dis Int (2010) 1.22
Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase. J Mol Biol (2007) 1.21
Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML. Cell Cycle (2006) 1.21
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest (2004) 1.21
Total synthesis of (+/-)-communesin F. J Am Chem Soc (2007) 1.20
Replacing alkoxy groups with alkylthienyl groups: a feasible approach to improve the properties of photovoltaic polymers. Angew Chem Int Ed Engl (2011) 1.20
Benefits of early tracheotomy: a meta-analysis based on 6 observational studies. Respir Care (2013) 1.20
Identification of transgelin-2 as a biomarker of colorectal cancer by laser capture microdissection and quantitative proteome analysis. Cancer Sci (2009) 1.19
Test-retest reproducibility of a rapid method to measure brain oxygen metabolism. Magn Reson Med (2012) 1.18
Microwave absorption properties of carbon nanocoils coated with highly controlled magnetic materials by atomic layer deposition. ACS Nano (2012) 1.17
Homeostatic regulation of sleep: a role for preoptic area neurons. J Neurosci (2006) 1.16
Genetic evolution of H9 subtype influenza viruses from live poultry markets in Shanghai, China. J Clin Microbiol (2009) 1.16
Repair of critical-sized rat calvarial defects using genetically engineered bone marrow-derived mesenchymal stem cells overexpressing hypoxia-inducible factor-1α. Stem Cells (2011) 1.14
Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese. J Hum Genet (2009) 1.14
Lead zirconate titanate nanowire textile nanogenerator for wearable energy-harvesting and self-powered devices. ACS Nano (2012) 1.14
Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res (2005) 1.13
The landscape of accessible chromatin in mammalian preimplantation embryos. Nature (2016) 1.13
Practical synthesis of a potent hepatitis C virus RNA replication inhibitor. J Org Chem (2004) 1.12
Genomic organization and functional analysis of murine PKD2L1. J Biol Chem (2004) 1.11