Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.

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Published in Cancer Cell on April 12, 2011

Authors

Wayne W Chan1, Scott C Wise, Michael D Kaufman, Yu Mi Ahn, Carol L Ensinger, Torsten Haack, Molly M Hood, Jennifer Jones, John W Lord, Wei Ping Lu, David Miller, William C Patt, Bryan D Smith, Peter A Petillo, Thomas J Rutkoski, Hanumaiah Telikepalli, Lakshminarayana Vogeti, Tony Yao, Lawrence Chun, Robin Clark, Peter Evangelista, L Cristina Gavrilescu, Katherine Lazarides, Virginia M Zaleskas, Lance J Stewart, Richard A Van Etten, Daniel L Flynn

Author Affiliations

1: Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.

Associated clinical trials:

Study Safety and Preliminary Efficacy of DCC-2036 in Patients With Leukemias (Ph+ CML With T315I Mutation) | NCT00827138

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