Published in Traffic on October 01, 2003
The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe (2008) 9.27
Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell (2009) 5.06
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol (2008) 4.72
Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. Proc Natl Acad Sci U S A (2009) 4.38
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog (2009) 4.24
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. PLoS Pathog (2009) 4.18
Inhibition of Lassa and Marburg virus production by tetherin. J Virol (2008) 3.98
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism. J Virol (2009) 3.67
Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog (2009) 3.66
Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog (2006) 3.57
Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion. Proc Natl Acad Sci U S A (2009) 3.47
Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein. J Virol (2009) 3.13
Membrane organization and lipid rafts. Cold Spring Harb Perspect Biol (2011) 2.98
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog (2009) 2.92
Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PLoS Pathog (2009) 2.92
Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J Virol (2009) 2.87
HIV Restriction Factors and Mechanisms of Evasion. Cold Spring Harb Perspect Med (2012) 2.72
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med (2009) 2.63
Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 2.55
Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe (2010) 2.44
HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. J Biol Chem (2009) 2.42
Host restriction factors blocking retroviral replication. Annu Rev Genet (2008) 2.41
The restriction factors of human immunodeficiency virus. J Biol Chem (2012) 2.36
Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Proc Natl Acad Sci U S A (2009) 2.21
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment. PLoS Pathog (2010) 2.12
Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV. Cell Host Microbe (2011) 2.11
The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. Retrovirology (2009) 2.11
The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu. J Virol (2009) 2.00
Human immunodeficiency virus, restriction factors, and interferon. J Interferon Cytokine Res (2009) 1.94
The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathog (2010) 1.94
A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol (2009) 1.90
Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog (2010) 1.89
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. J Biol Chem (2009) 1.89
HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology (2010) 1.87
Human cellular restriction factors that target HIV-1 replication. BMC Med (2009) 1.86
PredGPI: a GPI-anchor predictor. BMC Bioinformatics (2008) 1.86
Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane. PLoS Pathog (2010) 1.85
Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells. J Virol (2010) 1.83
BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol (2010) 1.82
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A (2009) 1.78
CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection. J Virol (2010) 1.63
Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol (2010) 1.61
Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein. J Virol (2010) 1.60
Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. PLoS Pathog (2012) 1.60
Stimulation of NF-κB activity by the HIV restriction factor BST2. J Virol (2012) 1.56
Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 1.56
Retroviral retention activates a Syk-dependent HemITAM in human tetherin. Cell Host Microbe (2014) 1.56
The great escape: viral strategies to counter BST-2/tetherin. PLoS Pathog (2010) 1.52
Lipids and membrane microdomains in HIV-1 replication. Virus Res (2009) 1.51
The structural biology of HIV-1: mechanistic and therapeutic insights. Nat Rev Microbiol (2012) 1.50
Novel approaches to inhibiting HIV-1 replication. Antiviral Res (2009) 1.48
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J Virol (2010) 1.48
Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal. J Virol (2010) 1.47
Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses. J Virol (2010) 1.39
Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility. J Virol (2010) 1.37
In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans. Proc Natl Acad Sci U S A (2011) 1.36
Antiviral activity of the interferon-induced cellular protein BST-2/tetherin. AIDS Res Hum Retroviruses (2009) 1.35
Tetherin restricts direct cell-to-cell infection of HIV-1. Retrovirology (2010) 1.34
HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem (2011) 1.30
HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction. MBio (2011) 1.30
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc Natl Acad Sci U S A (2010) 1.29
Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction. PLoS Pathog (2011) 1.29
Modulation of HIV-1-host interaction: role of the Vpu accessory protein. Retrovirology (2010) 1.26
Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity. Proc Natl Acad Sci U S A (2014) 1.26
Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses. PLoS One (2009) 1.22
A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction. PLoS Pathog (2012) 1.21
Vpu binds directly to tetherin and displaces it from nascent virions. PLoS Pathog (2013) 1.21
SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release. PLoS Pathog (2011) 1.20
BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology (2011) 1.20
HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol (2014) 1.19
HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef. Retrovirology (2011) 1.18
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virol (2011) 1.18
Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts. Proc Natl Acad Sci U S A (2009) 1.18
The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation. PLoS Pathog (2011) 1.18
Relationships between plasma membrane microdomains and HIV-1 assembly. Biol Cell (2010) 1.16
Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction. Viruses (2011) 1.13
Influenza virus partially counteracts restriction imposed by tetherin/BST-2. J Biol Chem (2012) 1.13
Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release. J Biol Chem (2010) 1.13
Viral hijacking of the host ubiquitin system to evade interferon responses. Curr Opin Microbiol (2010) 1.12
HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization. Future Virol (2009) 1.11
The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin. J Infect Dis (2011) 1.10
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure. Mol Biol Cell (2007) 1.09
Counteraction of the multifunctional restriction factor tetherin. Front Microbiol (2014) 1.09
HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms. Mol Aspects Med (2010) 1.09
Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. Virology (2011) 1.08
HIV accessory proteins versus host restriction factors. Curr Opin Virol (2013) 1.08
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS Pathog (2012) 1.08
The Role of Lipids in Retrovirus Replication. Viruses (2010) 1.07
Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin. J Virol (2010) 1.06
HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface. Traffic (2011) 1.06
A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo. PLoS Pathog (2012) 1.06
Separable determinants of subcellular localization and interaction account for the inability of group O HIV-1 Vpu to counteract tetherin. J Virol (2011) 1.05
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog (2013) 1.05
Host restriction factors in retroviral infection: promises in virus-host interaction. Retrovirology (2012) 1.05
A New World primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1. J Virol (2009) 1.05
BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog (2011) 1.04
Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev (2010) 1.02
Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts. J Virol (2012) 1.02
Tetherin inhibits prototypic foamy virus release. Virol J (2011) 1.02
C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif. J Biol Chem (2011) 1.01
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor. Cell Host Microbe (2009) 4.36
In search of an "autophagomometer". Autophagy (2009) 4.31
Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. J Cell Sci (2007) 2.90
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Huntington's disease: from pathology and genetics to potential therapies. Biochem J (2008) 2.41
Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex. Mol Cell (2005) 1.97
A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol (2009) 1.90
Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes. Mol Biol Cell (2002) 1.69
Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation. J Cell Sci (2003) 1.62
Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron (2005) 1.58
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy (2009) 1.36
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. J Biol Chem (2003) 1.30
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proc Natl Acad Sci U S A (2005) 1.28
A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. PLoS Pathog (2012) 1.21
CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles. Traffic (2002) 1.20
Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Mol Biol Cell (2006) 1.15
Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA). J Cell Sci (2004) 1.10
Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin. Curr Biol (2011) 1.10
Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Mol Biol Cell (2010) 1.08
Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos. Curr Biol (2002) 1.05
Ins(1,4,5)P3 metabolism and the family of IP3-3Kinases. Cell Signal (2004) 1.04
Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran. Mol Biol Cell (2008) 1.03
Herpes simplex virus 1 counteracts tetherin restriction via its virion host shutoff activity. J Virol (2013) 1.01
CD317/tetherin is an organiser of membrane microdomains. J Cell Sci (2013) 0.94
Phosphoinositide function in cytokinesis. Curr Biol (2011) 0.94
The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Mol Cell Biol (2010) 0.92
Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. J Cell Sci (2009) 0.89
Calpain cleavage of the B isoform of Ins(1,4,5)P3 3-kinase separates the catalytic domain from the membrane anchoring domain. Biochem J (2003) 0.86
Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett (2006) 0.86
Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells. Mol Cell Biol (2011) 0.85
Release of filamentous and spherical influenza A virus is not restricted by tetherin. J Gen Virol (2012) 0.85
Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site. Open Biol (2014) 0.85
The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos. Mol Biol Cell (2013) 0.84
Regulation of CK2 activity by phosphatidylinositol phosphates. J Biol Chem (2005) 0.84
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. J Biol Chem (2005) 0.82
Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation. PLoS One (2013) 0.80
The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif. Biol Open (2013) 0.79
IP3 3-kinase opposes NGF driven neurite outgrowth. PLoS One (2012) 0.79
Ran out of the nucleus for apoptosis. Nat Cell Biol (2009) 0.78
Characterisation of the lumenal domain of TGN38 and effects of elevated expression of TGN38 on glycoprotein secretion. Eur J Cell Biol (2002) 0.77
Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues. Biochem Biophys Res Commun (2004) 0.77
Glycolytic metabolites are critical modulators of oocyte maturation and viability. PLoS One (2013) 0.76
The site of RanGTP generation can act as an organizational cue for mitotic microtubules. Biol Cell (2011) 0.75