Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.

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Published in PLoS Pathog on May 15, 2009

Authors

Bin Jia1, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans

Author Affiliations

1: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA.

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Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239. PLoS Pathog (2009) 1.12

STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer. Int J Clin Exp Pathol (2010) 1.07

Benefit from adjuvant taxanes and endocrine responsiveness in breast cancer. Breast (2007) 1.06

Selection of adjuvant chemotherapy for treatment of node-positive breast cancer. Lancet Oncol (2005) 1.06

A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays. J Virol (2012) 1.06

Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog (2013) 1.05

Significant protection against high-dose simian immunodeficiency virus challenge conferred by a new prime-boost vaccine regimen. J Virol (2011) 1.05

Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine (2011) 1.01

Predictors of distress and quality of life in patients undergoing cancer therapy: impact of treatment type and decisional role. Psychooncology (2010) 1.01

Phage-mediated Shiga toxin 2 gene transfer in food and water. Appl Environ Microbiol (2009) 1.00

A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV. J Virol (2011) 0.99

Counteraction of HLA-C-mediated immune control of HIV-1 by Nef. J Virol (2010) 0.99

Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. PLoS Pathog (2013) 0.99

Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection. Genome Biol (2011) 0.99

A brief history of TRIM5alpha. AIDS Rev (2007) 0.98

The formation of inflammatory demyelinated lesions in cerebral white matter. Ann Neurol (2014) 0.98

In vivo replication of T4 and T7 bacteriophages in germ-free mice colonized with Escherichia coli. Virology (2009) 0.98

APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host. PLoS Pathog (2013) 0.98

Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2. J Virol (2008) 0.96

Host genes important to HIV replication and evolution. Cold Spring Harb Perspect Med (2012) 0.95

Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC). Curr Cancer Drug Targets (2011) 0.94

Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo. J Virol (2008) 0.94

Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions. J Virol (2011) 0.94

RB regulates pancreas development by stabilizing Pdx1. EMBO J (2011) 0.93

Clinical and biological significance of GSK-3β inactivation in breast cancer-an immunohistochemical study. Hum Pathol (2010) 0.93

Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology. J Neurovirol (2006) 0.92

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology (2007) 0.92

Generation of lineage-related, mucosally transmissible subtype C R5 simian-human immunodeficiency viruses capable of AIDS development, induction of neurological disease, and coreceptor switching in rhesus macaques. J Virol (2013) 0.91

Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity. PLoS Pathog (2013) 0.91

Diversity of envelope genes from an uncloned stock of SIVmac251. AIDS Res Hum Retroviruses (2010) 0.91

KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys. J Immunol (2014) 0.90

Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function. AIDS (2014) 0.89

Pushing the endogenous envelope. Philos Trans R Soc Lond B Biol Sci (2013) 0.88

Survival differences observed in metastatic breast cancer patients treated with capecitabine when compared with vinorelbine after pretreatment with anthracycline and taxane. Am J Clin Oncol (2007) 0.87

Complement synthesis and activation in the brain of SIV-infected monkeys. J Neuroimmunol (2004) 0.87

Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques. PLoS One (2011) 0.86

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose. Retrovirology (2014) 0.85

New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy. J Neuroimmune Pharmacol (2006) 0.84

Phase III trial comparing granulocyte colony-stimulating factor to leridistim in the prevention of neutropenic complications in breast cancer patients treated with docetaxel/doxorubicin/cyclophosphamide: results of the BCIRG 004 trial. Clin Breast Cancer (2002) 0.84

Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge. J Virol (2010) 0.84

Clinically validated benchmarking of normalisation techniques for two-colour oligonucleotide spotted microarray slides. Appl Bioinformatics (2003) 0.83

Tetherin upregulation in simian immunodeficiency virus-infected macaques. J Virol (2013) 0.82

Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism. J Virol (2007) 0.82

Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques. AIDS Res Hum Retroviruses (2013) 0.81

Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ. J Cell Sci (2013) 0.81

CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis. Blood (2014) 0.81

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques. Retrovirology (2013) 0.80

A novel recombinant retrovirus in the genomes of modern birds combines features of avian and mammalian retroviruses. J Virol (2013) 0.80

A machine learned classifier that uses gene expression data to accurately predict estrogen receptor status. PLoS One (2013) 0.79

Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques. J Virol (2011) 0.79

Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins. Breast Cancer Res Treat (2009) 0.79