Published in Acad Emerg Med on September 01, 2003
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Cardiac mitochondria and reactive oxygen species generation. Circ Res (2014) 1.51
Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium. J Biol Chem (2008) 1.12
The use of an early alert system to improve compliance with sepsis bundles and to assess impact on mortality. Crit Care Res Pract (2012) 0.98
The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol (2011) 0.90
Delineating the relationships among the formation of reactive oxygen species, cell membrane instability and innate autoimmunity in intestinal reperfusion injury. Mol Immunol (2013) 0.81
Complement C5 and early oxygen kinetics during murine sepsis. Acad Emerg Med (2005) 0.79
Lactate clearance in the acutely traumatized patient. Anesthesiology (2012) 0.75
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation (2011) 5.16
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. J Am Coll Cardiol (2012) 3.15
Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients. Crit Care Med (2004) 3.12
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med (2009) 2.92
Determination of left ventricular function by emergency physician echocardiography of hypotensive patients. Acad Emerg Med (2002) 2.35
Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients. Eur Heart J (2007) 2.26
Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study. Chest (2006) 2.22
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas (2010) 2.19
The chest pain choice decision aid: a randomized trial. Circ Cardiovasc Qual Outcomes (2012) 2.15
Evaluation of pulmonary embolism in the emergency department and consistency with a national quality measure: quantifying the opportunity for improvement. Arch Intern Med (2012) 2.15
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism. Acad Emerg Med (2010) 1.95
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting. Clin J Am Soc Nephrol (2009) 1.74
Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients. Crit Care Med (2005) 1.72
Risk of thromboembolism varies, depending on category of immobility in outpatients. Ann Emerg Med (2009) 1.71
Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock. Am J Emerg Med (2008) 1.66
Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65
Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare. Acad Emerg Med (2011) 1.59
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care (2009) 1.57
Systematic review of emergency physician-performed ultrasonography for lower-extremity deep vein thrombosis. Acad Emerg Med (2008) 1.49
Procalcitonin test in the diagnosis of bacteremia: a meta-analysis. Ann Emerg Med (2006) 1.49
Nontraumatic out-of-hospital hypotension predicts inhospital mortality. Ann Emerg Med (2004) 1.44
Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543. Crit Care Med (2011) 1.43
Prevalence and significance of nonthromboembolic findings on chest computed tomography angiography performed to rule out pulmonary embolism: a multicenter study of 1,025 emergency department patients. Acad Emerg Med (2004) 1.43
Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study. Ann Emerg Med (2010) 1.37
Focused training of emergency medicine residents in goal-directed echocardiography: a prospective study. Acad Emerg Med (2003) 1.31
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24
Systematic bias introduced by the informed consent process in a diagnostic research study. Acad Emerg Med (2008) 1.21
High discordance of chest x-ray and computed tomography for detection of pulmonary opacities in ED patients: implications for diagnosing pneumonia. Am J Emerg Med (2012) 1.21
Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry). J Am Coll Cardiol (2011) 1.19
Severity of emergency department hypotension predicts adverse hospital outcome. Shock (2004) 1.16
Chemokines accumulate in the lungs of rats with severe pulmonary embolism induced by polystyrene microspheres. J Immunol (2003) 1.11
Further illumination of the test threshold approach in the care of emergency department patients with symptoms of pulmonary embolism. Ann Emerg Med (2010) 1.09
Emergency medicine practitioner knowledge and use of decision rules for the evaluation of patients with suspected pulmonary embolism: variations by practice setting and training level. Acad Emerg Med (2006) 1.06
Clinical features of patients with pulmonary embolism and a negative PERC rule result. Ann Emerg Med (2013) 1.05
Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography. Acad Emerg Med (2012) 1.04
Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department. BMC Med Inform Decis Mak (2008) 1.03
Intraobserver and interobserver agreement of the interpretation of pediatric chest radiographs. Emerg Radiol (2010) 1.02
Predictors of the complication of postintubation hypotension during emergency airway management. J Crit Care (2012) 1.02
Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats. J Mol Cell Cardiol (2006) 1.01
Emergency echocardiography to detect pericardial effusion in patients in PEA and near-PEA states. Resuscitation (2003) 0.97
The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Med (2009) 0.97
Determination of the effect of in vitro time, temperature, and tourniquet use on whole blood venous point-of-care lactate concentrations. Acad Emerg Med (2007) 0.97
Comparison of the unstructured clinician estimate of pretest probability for pulmonary embolism to the Canadian score and the Charlotte rule: a prospective observational study. Acad Emerg Med (2005) 0.97
The frequency and significance of postintubation hypotension during emergency airway management. J Crit Care (2011) 0.97
Prospective multicenter study of quantitative pretest probability assessment to exclude acute coronary syndrome for patients evaluated in emergency department chest pain units. Ann Emerg Med (2006) 0.94
Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. Am J Physiol Lung Cell Mol Physiol (2003) 0.93
The Chest Pain Choice trial: a pilot randomized trial of a decision aid for patients with chest pain in the emergency department. Trials (2010) 0.93
Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (2013) 0.91
Potential impact of adjusting the threshold of the quantitative D-dimer based on pretest probability of acute pulmonary embolism. Acad Emerg Med (2009) 0.91
Interobserver agreement for the diagnosis of venous thromboembolism on computed tomography chest angiography and indirect venography of the lower extremities in emergency department patients. Acad Emerg Med (2006) 0.91
Emergency department resuscitative procedures: animal laboratory training improves procedural competency and speed. Acad Emerg Med (2002) 0.89
Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock (2012) 0.89
End tidal CO(2) is reduced during hypotension and cardiac arrest in a rat model of massive pulmonary embolism. Resuscitation (2002) 0.87
Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats. Thromb J (2010) 0.86
Therapy and outcomes in massive pulmonary embolism from the Emergency Medicine Pulmonary Embolism in the Real World Registry. Am J Emerg Med (2012) 0.86
Proteomics of microparticles after experimental pulmonary embolism. Thromb Res (2011) 0.85
Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department. Clin Chem (2006) 0.85
Multimarker panel to rule out acute coronary syndromes in low-risk patients. Acad Emerg Med (2006) 0.85
Effect of glucose-insulin-potassium infusion on mortality in critical care settings: a systematic review and meta-analysis. J Clin Pharmacol (2009) 0.84
Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension. J Card Fail (2010) 0.84
Inhibition of CINC-1 decreases right ventricular damage caused by experimental pulmonary embolism in rats. J Immunol (2007) 0.84
Estimating the pretest probability threshold to justify empiric administration of heparin prior to pulmonary vascular imaging for pulmonary embolism. Thromb Res (2005) 0.84
12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism. Ann Emerg Med (2009) 0.83
Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats. Physiol Genomics (2008) 0.83
Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism. Pulm Pharmacol Ther (2011) 0.82
Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial. Trials (2014) 0.82
Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism. Pulm Pharmacol Ther (2011) 0.81
Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats. Physiol Genomics (2009) 0.80
Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat. Shock (2003) 0.80
Prospective use of a clinical decision rule to identify pulmonary embolism as likely cause of outpatient cardiac arrest. Resuscitation (2005) 0.80
Evaluation of capnography using a genetic algorithm to predict PaCO2. Chest (2005) 0.79
Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. J Thromb Thrombolysis (2015) 0.79
Prognostic value of incremental lactate elevations in emergency department patients with suspected infection. Acad Emerg Med (2012) 0.79
Venous thromboembolism: EINSTEIN transforms anticoagulant therapy in acute PE. Nat Rev Cardiol (2012) 0.79
Lack of association between prehospital response times and patient outcomes. Prehosp Emerg Care (2009) 0.79
Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia. Vasc Endovascular Surg (2003) 0.78
Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes (2014) 0.78
Direct comparison of the diagnostic accuracy of fifty protein biological markers of pulmonary embolism for use in the emergency department. Acad Emerg Med (2008) 0.78
Fatal pulmonary embolism immediately after transatlantic air travel to the United States: less than one in a million. Thromb Haemost (2002) 0.78
The art and science of probabilistic decision-making in emergency medicine. Acad Emerg Med (2010) 0.78
Contrast-induced nephropathy: doubts and certainties. Acad Emerg Med (2012) 0.78
The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion. J Am Coll Surg (2003) 0.77
Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats. J Cardiovasc Pharmacol (2009) 0.77
Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department. Acad Emerg Med (2008) 0.76
A soluble guanylate cyclase stimulator, BAY 41-8543, preserves right ventricular function in experimental pulmonary embolism. Pulm Pharmacol Ther (2012) 0.76
The beneficial effects of dichloroacetate in acute limb ischemia. Mil Med (2007) 0.76
Risk stratification of community-acquired pneumonia: what does all of this mean? Ann Emerg Med (2008) 0.75
Diagnosing pulmonary embolism in the emergency department: maybe we do matter, after all. Emerg Med Australas (2009) 0.75
End expiratory oxygen concentrations to predict central venous oxygen saturation: an observational pilot study. BMC Emerg Med (2006) 0.75
More on the PERC rule. Ann Emerg Med (2012) 0.75
Pleural effusions in the critically ill: the evolving role of bedside ultrasound. Crit Care Med (2005) 0.75
A primer on the complicated subject of cost-effectiveness analyses for pulmonary embolism. Ann Emerg Med (2010) 0.75