Published in JAMA on February 24, 2010
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation (LactATES) | NCT00372502
Lactate Clearance According to the Presence of Hepatic Dysfunction | NCT01709565
Restrictive Intravenous Fluids Trial in Sepsis (RIFTS) | NCT03137446
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Med (2015) 4.95
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
Fluid challenges in intensive care: the FENICE study: A global inception cohort study. Intensive Care Med (2015) 3.27
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Septic Shock: Advances in Diagnosis and Treatment. JAMA (2015) 2.37
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock. J Emerg Med (2012) 2.02
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med (2014) 1.84
Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc (2013) 1.72
Biases introduced by choosing controls to match risk factors of cases in biomarker research. Clin Chem (2012) 1.69
Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65
An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit Care Med (2015) 1.58
Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care (2013) 1.49
Biomarkers of sepsis. Crit Rev Clin Lab Sci (2013) 1.48
Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways. Crit Care Med (2015) 1.46
The PICU perspective on monitoring hemodynamics and oxygen transport. Pediatr Crit Care Med (2011) 1.46
Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. Crit Care Resusc (2013) 1.45
Prognostic Value of Lactate and Central Venous Oxygen Saturation after Early Resuscitation in Sepsis Patients. PLoS One (2016) 1.42
Central venous-to-arterial carbon dioxide difference as a prognostic tool in high-risk surgical patients. Crit Care (2015) 1.42
Extracorporeal life support following out-of-hospital refractory cardiac arrest. Crit Care (2011) 1.40
Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evid Based Complement Alternat Med (2016) 1.38
Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review. Scand J Trauma Resusc Emerg Med (2011) 1.38
The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials. Crit Care (2014) 1.35
Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups. Crit Care (2013) 1.35
Hospital-based acute care use in survivors of septic shock. Crit Care Med (2015) 1.34
Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. Chest (2011) 1.33
The impact of emergency medical services on the ED care of severe sepsis. Am J Emerg Med (2010) 1.30
Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther (2011) 1.27
Counterpoint: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? No. Chest (2011) 1.26
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24
Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation. Crit Care (2011) 1.20
Sepsis-associated hyperlactatemia. Crit Care (2014) 1.17
Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study. Ann Intensive Care (2013) 1.15
Accuracy of Handheld Point-of-Care Fingertip Lactate Measurement in the Emergency Department. West J Emerg Med (2013) 1.15
Central venous O₂ saturation and venous-to-arterial CO₂ difference as complementary tools for goal-directed therapy during high-risk surgery. Crit Care (2010) 1.10
Dynamic lactate indices as predictors of outcome in critically ill patients. Crit Care (2011) 1.09
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
Prevalence and characteristics of nonlactate and lactate expressors in septic shock. J Crit Care (2012) 1.04
Surviving sepsis: going beyond the guidelines. Ann Intensive Care (2011) 1.02
Pharmacologic agents for acute hemodynamic instability: Recent advances in the management of perioperative shock- A systematic review. Ann Card Anaesth (2015) 1.01
Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach. Crit Care (2014) 1.01
Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health. J Proteome Res (2013) 1.00
Brazilian recommendations of mechanical ventilation 2013. Part 2. J Bras Pneumol (2014) 0.99
Lactate as a hemodynamic marker in the critically ill. Curr Opin Crit Care (2012) 0.99
The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99
The use of an early alert system to improve compliance with sepsis bundles and to assess impact on mortality. Crit Care Res Pract (2012) 0.98
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care (2014) 0.98
Post-Acute Care Use and Hospital Readmission after Sepsis. Ann Am Thorac Soc (2015) 0.97
Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials. BMC Med (2015) 0.97
Biomarkers for sepsis: a review with special attention to India. Biomed Res Int (2014) 0.97
Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock. Intensive Care Med (2015) 0.96
Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle. Crit Care (2011) 0.96
Clinical applicability of functional hemodynamic monitoring. Ann Intensive Care (2011) 0.96
When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring. Ann Intensive Care (2014) 0.96
The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care (2016) 0.95
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
Feasibility of modified surviving sepsis campaign guidelines in a resource-restricted setting based on a cohort study of severe S. aureus sepsis [corrected]. PLoS One (2012) 0.95
Prevention and treatment of sepsis-induced acute kidney injury: an update. Ann Intensive Care (2015) 0.95
Severe sepsis and septic shock: management and performance improvement. Virulence (2013) 0.94
Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock. Scand J Trauma Resusc Emerg Med (2012) 0.94
Prognostic utility of plasma lactate measured between 24 and 48 h after initiation of early goal-directed therapy in the management of sepsis, severe sepsis, and septic shock. J Intensive Care (2016) 0.94
The impact of hyperlactatemia on postoperative outcome after adult cardiac surgery. J Anesth (2011) 0.93
Fluid management and risk factors for renal dysfunction in patients with severe sepsis and/or septic shock. Crit Care (2012) 0.93
Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92
The effect of intra-abdominal hypertension incorporating severe acute pancreatitis in a porcine model. PLoS One (2012) 0.92
"Early goal-directed therapy" versus "Early" and "goal-directed" therapy for severe sepsis and septic shock: Time to rationalize. Lung India (2015) 0.91
Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study. Intensive Care Med (2013) 0.91
Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (2013) 0.91
Pre-resuscitation lactate and hospital mortality in prehospital patients. Prehosp Emerg Care (2014) 0.91
Sepsis-associated pulmonary complications in emergency department patients monitored with serial lactate: An observational cohort study. J Crit Care (2015) 0.88
Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center. Support Care Cancer (2012) 0.88
Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study. Ann Intensive Care (2012) 0.88
Multicenter Implementation of a Treatment Bundle for Patients with Sepsis and Intermediate Lactate Values. Am J Respir Crit Care Med (2016) 0.87
Lactate clearance as a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review study protocol. BMJ Open (2014) 0.87
A new device for continuous assessment of gut perfusion: proof of concept on a porcine model of septic shock. Crit Care (2014) 0.87
Controversies in fluid therapy: Type, dose and toxicity. World J Crit Care Med (2014) 0.87
Improving risk classification of critical illness with biomarkers: a simulation study. J Crit Care (2013) 0.87
Brazilian recommendations of mechanical ventilation 2013. Part 2. Rev Bras Ter Intensiva (2014) 0.85
Lactate and lactate clearance in acute cardiac care patients. Eur Heart J Acute Cardiovasc Care (2012) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Fluid resuscitation in septic shock: too much, too little or just right? Crit Care (2012) 0.85
The Surviving Sepsis Campaign's Revised Sepsis Bundles. Curr Infect Dis Rep (2013) 0.84
Lactate clearance for assessing response to resuscitation in severe sepsis. Acad Emerg Med (2013) 0.84
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. Proc Natl Acad Sci U S A (2015) 0.84
Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study. Crit Care (2014) 0.83
Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc (2015) 0.83
Sepsis and pregnancy: do we know how to treat this situation? Rev Bras Ter Intensiva (2014) 0.83
Early management of sepsis. Clin Exp Emerg Med (2014) 0.82
Disassembling goal-directed therapy for sepsis: a first step. JAMA (2010) 0.82
A Computerized Alert Screening for Severe Sepsis in Emergency Department Patients Increases Lactate Testing but does not Improve Inpatient Mortality. Appl Clin Inform (2010) 0.81
Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial. Crit Care (2015) 0.81
Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels. Crit Care Med (2015) 0.81
Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients. Am J Emerg Med (2014) 0.81
Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics. Shock (2015) 0.81
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med (1996) 35.00
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA (1994) 27.36
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med (2007) 10.02
Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest (1988) 6.29
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med (2004) 5.64
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med (2006) 4.62
Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med (2007) 4.42
Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med (2003) 4.25
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Barriers to implementing protocol-based sepsis resuscitation in the emergency department--results of a national survey. Crit Care Med (2007) 3.28
Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation (1970) 2.72
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med (2004) 2.33
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care (2006) 1.77
Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines--does one size fit all? Crit Care (2008) 1.46
The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med (2009) 1.41
Early goal-directed therapy of septic shock: we honestly remain skeptical. Crit Care Med (2007) 1.22
Bench to bedside: the role of mitochondrial medicine in the pathogenesis and treatment of cellular injury. Acad Emerg Med (2003) 1.17
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation (2011) 5.16
Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med (2007) 4.54
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. J Am Coll Cardiol (2012) 3.15
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med (2010) 3.13
Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients. Crit Care Med (2004) 3.12
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med (2009) 2.92
Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest (2006) 2.69
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
Determination of left ventricular function by emergency physician echocardiography of hypotensive patients. Acad Emerg Med (2002) 2.35
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients. Eur Heart J (2007) 2.26
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. Circulation (2013) 2.22
Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study. Chest (2006) 2.22
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas (2010) 2.19
The chest pain choice decision aid: a randomized trial. Circ Cardiovasc Qual Outcomes (2012) 2.15
Evaluation of pulmonary embolism in the emergency department and consistency with a national quality measure: quantifying the opportunity for improvement. Arch Intern Med (2012) 2.15
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism. Acad Emerg Med (2010) 1.95
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
Serum lactate as a predictor of mortality in patients with infection. Intensive Care Med (2007) 1.88
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting. Clin J Am Soc Nephrol (2009) 1.74
Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients. Crit Care Med (2005) 1.72
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
Risk of thromboembolism varies, depending on category of immobility in outpatients. Ann Emerg Med (2009) 1.71
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med (2009) 1.68
Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock. Am J Emerg Med (2008) 1.66
Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare. Acad Emerg Med (2011) 1.59
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care (2009) 1.57
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma (2009) 1.53
Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc (2009) 1.53
Systematic review of emergency physician-performed ultrasonography for lower-extremity deep vein thrombosis. Acad Emerg Med (2008) 1.49
Procalcitonin test in the diagnosis of bacteremia: a meta-analysis. Ann Emerg Med (2006) 1.49
Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48
Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med (2012) 1.48
Characteristics of out-of-hospital shock care. Crit Care Med (2011) 1.47
Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility study. Acad Emerg Med (2008) 1.46
Predicting adverse outcomes in syncope. J Emerg Med (2007) 1.45
Nontraumatic out-of-hospital hypotension predicts inhospital mortality. Ann Emerg Med (2004) 1.44
Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med (2007) 1.44
Arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest*. Crit Care Med (2014) 1.43
Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543. Crit Care Med (2011) 1.43
Prevalence and significance of nonthromboembolic findings on chest computed tomography angiography performed to rule out pulmonary embolism: a multicenter study of 1,025 emergency department patients. Acad Emerg Med (2004) 1.43
The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med (2009) 1.41
C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med (2014) 1.41
Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study. Ann Emerg Med (2010) 1.37
The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care (2013) 1.34
Clinical review: Emergency department overcrowding and the potential impact on the critically ill. Crit Care (2004) 1.33
Charlson Index is associated with one-year mortality in emergency department patients with suspected infection. Acad Emerg Med (2006) 1.32
Focused training of emergency medicine residents in goal-directed echocardiography: a prospective study. Acad Emerg Med (2003) 1.31
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24