Published in Mol Biol Cell on May 29, 2003
Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol Biol Cell (2005) 2.49
A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development. PLoS Pathog (2008) 1.65
Host cell manipulation by the human pathogen Toxoplasma gondii. Cell Mol Life Sci (2008) 1.49
Immobilization of the type XIV myosin complex in Toxoplasma gondii. Mol Biol Cell (2007) 1.16
A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress. PLoS Pathog (2013) 1.08
Role of cholesterol in parasitic infections. Lipids Health Dis (2005) 1.04
Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors. Biochem J (2006) 1.02
Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. Mol Biol Cell (2013) 0.92
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity. Proc Natl Acad Sci U S A (2008) 0.89
The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force. BMC Biol (2014) 0.88
The inner membrane complex through development of Toxoplasma gondii and Plasmodium. Cell Microbiol (2014) 0.87
Characterization of a second sterol-esterifying enzyme in Toxoplasma highlights the importance of cholesterol storage pathways for the parasite. Mol Microbiol (2013) 0.85
Role of an ancestral d-bifunctional protein containing two sterol-carrier protein-2 domains in lipid uptake and trafficking in Toxoplasma. Mol Biol Cell (2008) 0.85
Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. PLoS Pathog (2011) 0.85
Francisella tularensis uses cholesterol and clathrin-based endocytic mechanisms to invade hepatocytes. Sci Rep (2011) 0.84
Fierce competition between Toxoplasma and Chlamydia for host cell structures in dually infected cells. Eukaryot Cell (2012) 0.83
Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol (2017) 0.81
A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging. Cell Microbiol (2012) 0.80
A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress. J Biol Chem (2015) 0.80
Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. PLoS One (2012) 0.79
Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles. Eukaryot Cell (2015) 0.78
Recent developments in the interactions between caveolin and pathogens. Adv Exp Med Biol (2012) 0.78
Disruption of lipid rafts interferes with the interaction of Toxoplasma gondii with macrophages and epithelial cells. Biomed Res Int (2014) 0.78
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol (2017) 0.77
Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. Parasitol Res (2014) 0.77
Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption. PLoS One (2014) 0.77
Primary intraocular (retinal) lymphoma after ocular toxoplasmosis. Retin Cases Brief Rep (2010) 0.77
Interaction of pathogens with host cholesterol metabolism. Curr Opin Lipidol (2014) 0.77
Eimeria bovis infection modulates endothelial host cell cholesterol metabolism for successful replication. Vet Res (2015) 0.76
Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum. PLoS Pathog (2016) 0.75
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
A receptor-mediated pathway for cholesterol homeostasis. Science (1986) 19.28
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat Cell Biol (2001) 8.93
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol (1994) 5.50
Cholesterol and the Golgi apparatus. Science (1993) 5.45
Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell (1996) 5.01
Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur J Cell Biol (1997) 4.29
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci U S A (1999) 3.95
Toxoplasmosis in pregnancy. Clin Infect Dis (1994) 3.91
Essential role for cholesterol in entry of mycobacteria into macrophages. Science (2000) 3.36
Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem J (1998) 3.22
Involvement of cellular caveolae in bacterial entry into mast cells. Science (2000) 2.96
Cellular cholesterol efflux mediated by cyclodextrins. Demonstration Of kinetic pools and mechanism of efflux. J Biol Chem (1996) 2.93
ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell (2000) 2.92
Secretion of micronemal proteins is associated with toxoplasma invasion of host cells. Cell Microbiol (1999) 2.74
Lysosome-related organelles. FASEB J (2000) 2.73
Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii. Mol Microbiol (1999) 2.69
Toxoplasma invasion: the parasitophorous vacuole is formed from host cell plasma membrane and pinches off via a fission pore. Proc Natl Acad Sci U S A (1996) 2.63
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole. EMBO J (2001) 2.62
Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. Members of the ACTG 077p/ANRS 009 Study Team. N Engl J Med (1993) 2.55
Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles. J Virol (2002) 2.33
Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. J Cell Biol (1999) 2.30
Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate. J Cell Biol (1992) 2.30
The Toxoplasma gondii rhoptry protein ROP 2 is inserted into the parasitophorous vacuole membrane, surrounding the intracellular parasite, and is exposed to the host cell cytoplasm. J Cell Biol (1994) 2.26
Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii. Mol Microbiol (1997) 2.21
Retracted Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking. J Biol Chem (1998) 2.18
Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways. Exp Parasitol (1999) 2.17
Cholesterol as modulator of receptor function. Biochemistry (1997) 2.10
Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. J Biol Chem (2001) 2.07
The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts. J Cell Biol (1989) 1.98
Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J Exp Med (1999) 1.96
Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J Cell Biol (2000) 1.96
Surface antigens of Toxoplasma gondii. Parasitology (1988) 1.81
Kinetics and pattern of organelle exocytosis during Toxoplasma gondii/host-cell interaction. Parasitol Res (1993) 1.76
Cholesterol-phospholipid interaction in membranes. 2. Stoichiometry and molecular packing of cholesterol-rich domains. Biochemistry (1982) 1.67
Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells. J Cell Biol (1983) 1.66
The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite. Cell Microbiol (2000) 1.58
Targeting of Shiga toxin B-subunit to retrograde transport route in association with detergent-resistant membranes. Mol Biol Cell (2001) 1.57
Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms. Nat Cell Biol (2000) 1.57
Characterization of the protein contents of rhoptries and dense granules of Toxoplasma gondii tachyzoites by subcellular fractionation and monoclonal antibodies. Mol Biochem Parasitol (1991) 1.56
Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J Cell Sci (2002) 1.54
The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes. J Cell Sci (1993) 1.53
Secretion from the rhoptries of Toxoplasma gondii during host-cell invasion. J Ultrastruct Res (1983) 1.52
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids. J Lipid Res (1991) 1.48
Transmission and scanning electron microscopy of host cell entry by Toxoplasma gondii. Am J Pathol (1977) 1.48
Vacuolar uptake of host components, and a role for cholesterol and sphingomyelin in malarial infection. EMBO J (2000) 1.45
Caveolae as portals of entry for microbes. Microbes Infect (2001) 1.43
The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans. Mol Biochem Parasitol (2001) 1.43
Lamellar membranes associated with rhoptries in erythrocytic merozoites of Plasmodium knowlesi: a clue to the mechanism of invasion. Parasitology (1986) 1.41
The role of cholesterol and glycosylphosphatidylinositol-anchored proteins of erythrocyte rafts in regulating raft protein content and malarial infection. J Biol Chem (2001) 1.37
Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. J Biol Chem (1992) 1.30
Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment. Infect Immun (2000) 1.29
Caveolins and cellular cholesterol balance. Traffic (2000) 1.29
Filipin-cholesterol complexes form in uncoated vesicle membrane derived from coated vesicles during receptor-mediated endocytosis of low density lipoprotein. J Cell Biol (1983) 1.29
The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms. J Cell Biol (1998) 1.27
Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii. Proc Natl Acad Sci U S A (2001) 1.26
Laminin enhances binding of Toxoplasma gondii tachyzoites to J774 murine macrophage cells. Infect Immun (1992) 1.25
The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem (2002) 1.24
Progesterone blocks cholesterol translocation from lysosomes. J Biol Chem (1992) 1.20
Intracellular cholesterol trafficking: role of the NPC1 protein. Biochim Biophys Acta (2000) 1.20
Caveolae in the uptake and targeting of infectious agents and secreted toxins. Adv Drug Deliv Rev (2001) 1.18
Laminin on Toxoplasma gondii mediates parasite binding to the beta 1 integrin receptor alpha 6 beta 1 on human foreskin fibroblasts and Chinese hamster ovary cells. Infect Immun (1992) 1.18
Identification of caveolin-1 in lipoprotein particles secreted by exocrine cells. Nat Cell Biol (1999) 1.14
Niemann-Pick type C mutations cause lipid traffic jam. Traffic (2000) 1.12
Co-option of endocytic functions of cellular caveolae by pathogens. Immunology (2001) 1.11
Cloning of a cDNA encoding the dense granule protein GRA3 from Toxoplasma gondii. Mol Biochem Parasitol (1994) 1.09
Current concepts of membrane structure and function. Fed Proc (1969) 1.08
Intracellular cholesterol transport. J Lipid Res (1992) 1.07
Host plasma low density lipoprotein particles as an essential source of lipids for the bloodstream forms of Trypanosoma brucei. J Biol Chem (1995) 1.04
Characterization of the lipid content of Toxoplasma gondii rhoptries. Parasitology (1991) 1.00
Cholesterol requirement for cation-independent mannose 6-phosphate receptor exit from multivesicular late endosomes to the Golgi. J Cell Sci (2001) 0.97
Lipid domains in membranes. Ann N Y Acad Sci (1982) 0.97
Host cell surface sialic acid residues are involved on the process of penetration of Toxoplasma gondii into mammalian cells. FEMS Microbiol Lett (1998) 0.92
Labeling of cholesterol with filipin in cellular membranes of parenchymatous organs. Standardization of incubation conditions. Histochemistry (1987) 0.89
Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. J Biol Chem (1993) 0.88
Alteration of 86Rb+ influx and efflux following depletion of membrane sterol in L-cells. J Biol Chem (1978) 0.86
Distribution of intramembranous particles and filipin-sterol complexes in the cell membranes of Toxoplasma gondii. Eur J Cell Biol (1985) 0.81
Host-parasite relationship in Pneumocystis carinii infection: activation of the plasmalemmal vesicular system in type I alveolar epithelial cells. J Protozool (1992) 0.80
Labeled probes inserted in the macrophage membrane are transferred to the parasite surface and internalized during cell invasion by Toxoplasma gondii. Parasitol Res (2000) 0.78
Filipin labeling in Chlamydomonas gametes exposes site-specific lipid specializations. Cell Mol Biol (1992) 0.77
Distribution of filipin-sterol complexes in the bloodstream form of Trypanosoma brucei gambiense. J Electron Microsc (Tokyo) (1992) 0.76
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space. Cell (2006) 2.79
Golgi biogenesis in Toxoplasma gondii. Nature (2002) 1.67
Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (2008) 1.47
Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. J Biol Chem (2005) 1.27
The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem (2002) 1.24
AP-1 in Toxoplasma gondii mediates biogenesis of the rhoptry secretory organelle from a post-Golgi compartment. J Biol Chem (2002) 1.12
On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzyme. Mol Biochem Parasitol (2004) 1.10
Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma. Cell Microbiol (2005) 1.08
Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells. Cell Microbiol (2002) 1.08
Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules? Mol Microbiol (2004) 1.08
A family of aspartic proteases and a novel, dynamic and cell-cycle-dependent protease localization in the secretory pathway of Toxoplasma gondii. Traffic (2007) 1.04
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrob Agents Chemother (2008) 1.04
Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis. Infect Immun (2004) 1.02
Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum. Cell Microbiol (2007) 1.02
The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation. J Cell Sci (2004) 1.00
Traffic to the malaria parasite food vacuole: a novel pathway involving a phosphatidylinositol 3-phosphate-binding protein. J Biol Chem (2007) 0.96
Characterisation of Toxoplasma gondii engineered to express mouse interferon-gamma. Int J Parasitol (2003) 0.96
Pleiotropic effect due to targeted depletion of secretory rhoptry protein ROP2 in Toxoplasma gondii. J Cell Sci (2003) 0.95
Neutral lipid synthesis and storage in the intraerythrocytic stages of Plasmodium falciparum. Mol Biochem Parasitol (2004) 0.95
Peculiarities of host cholesterol transport to the unique intracellular vacuole containing Toxoplasma. Traffic (2005) 0.95
Toxoplasma gondii Rab6 mediates a retrograde pathway for sorting of constitutively secreted proteins to the Golgi complex. J Biol Chem (2002) 0.92
A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase. J Biol Chem (2003) 0.91
Toxoplasma gondii is capable of exogenous folate transport. A likely expansion of the BT1 family of transmembrane proteins. Mol Biochem Parasitol (2005) 0.91
Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum. Antimicrob Agents Chemother (2006) 0.90
Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii. J Biol Chem (2004) 0.89
Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma. Mol Microbiol (2010) 0.87
A comprehensive space management model for facilitating programmatic research. Acad Med (2008) 0.85
Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem (2003) 0.80
Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. PLoS One (2012) 0.79
Improving clinical productivity in the academic setting: a novel incentive plan based on utility theory. Acad Med (2006) 0.77
Plasmodium falciparum: discovery of peroxidase active organelles. Exp Parasitol (2005) 0.76