Published in J Pharmacol Exp Ther on March 01, 1953
Synthetic substances with morphine-like effect; relationship between analgesic action and addiction liability, with a discussion of the chemical structure of addiction-producing substances. Bull World Health Organ (1956) 3.60
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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci (2010) 2.73
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. PLoS Biol (2015) 2.30
Experimental observations on Haffner's method for testing analgesic drugs. Br J Pharmacol Chemother (1954) 2.13
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The influence of non-nociceptive factors on hot-plate latency in rats. J Pain (2010) 1.48
QUANTITATIVE STUDIES OF THE ANTAGONISM BY NALORPHINE OF SOME OF THE ACTIONS OF MORPHINE-LIKE ANALGESIC DRUGS. Br J Pharmacol Chemother (1964) 1.47
An early diagnostic tool for diabetic peripheral neuropathy in rats. PLoS One (2015) 1.38
Experimental evaluation of analgesic and anti-inflammatory potential of Oyster mushroom Pleurotus florida. Indian J Pharmacol (2013) 1.32
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol (2004) 1.09
Nicotine physical dependence and tolerance in the mouse following chronic oral administration. Psychopharmacology (Berl) (2004) 1.08
Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. Tissue Eng Part B Rev (2010) 1.02
CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist. Neuropharmacology (2007) 1.02
Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice. ScientificWorldJournal (2013) 0.98
An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage. Nat Neurosci (2016) 0.98
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol (2009) 0.96
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Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs. Bioorg Med Chem (2007) 0.95
Similarly between receptors responsible for the production of analgesia and lenticular opacity. Br J Pharmacol Chemother (1961) 0.94
Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain (2011) 0.94
The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. Mar Drugs (2009) 0.93
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS One (2012) 0.92
Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene. Mamm Genome (2014) 0.91
Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice. Br J Pharmacol (1996) 0.91
Experimental study of neuropharmacological profile of Euphorbia pulcherrima in mice and rats. J Neurosci Rural Pract (2012) 0.91
Significant determinants of mouse pain behaviour. PLoS One (2014) 0.91
Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. Int J Mol Sci (2010) 0.90
Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies. Indian J Med Res (2012) 0.90
Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain (2011) 0.89
Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. Br J Pharmacol (2006) 0.89
Leaves extract of murraya koenigii linn for anti-inflammatory and analgesic activity in animal models. J Adv Pharm Technol Res (2010) 0.89
Exercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female rats. Clinics (Sao Paulo) (2011) 0.88
Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors. Brain Res (2010) 0.87
CC12, a P450/epoxygenase inhibitor, acts in the rat rostral, ventromedial medulla to attenuate morphine antinociception. Brain Res (2013) 0.87
Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice. BMC Complement Altern Med (2014) 0.87
Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. Int J Mol Sci (2012) 0.86
Analgesic activity of crude aqueous extract of the root bark of zanthoxylum xanthoxyloides. Ghana Med J (2008) 0.86
Comparative analgesic effect of Ligusticum chuanxiong pieces and its products in mice. Pharmacogn Mag (2010) 0.86
Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. Inflammopharmacology (2009) 0.86
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B (2015) 0.85
Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A(2A) receptor knockout mice. Br J Pharmacol (2008) 0.85
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain. Br J Pharmacol (1993) 0.85
Modulation of morphine antinociception in the mouse by endogenous nitric oxide. Br J Pharmacol (1994) 0.85
Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.85
Antinociception effect and mechanisms of campanula punctata extract in the mouse. Korean J Physiol Pharmacol (2010) 0.84
Antinociceptive and anti-inflammatory effects of ethanol extract from Vernonia polyanthes leaves in Rodents. Int J Mol Sci (2012) 0.84
Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modesta leaves. Inflammopharmacology (2010) 0.84
Facilitation of development of resistance to morphine analgesia by desglycinamide9-lysine vasopressin. Proc Natl Acad Sci U S A (1974) 0.84
Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats. Diabetes (2012) 0.83
Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo. Br J Pharmacol (1995) 0.83
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice. BMC Complement Altern Med (2015) 0.83
Evaluation of Analgesic and Antipyretic Activities of Centratherum anthelminticum (L) Kuntze Seed. Indian J Pharm Sci (2009) 0.83
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology (Berl) (2007) 0.83
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. J Med Food (2010) 0.82
Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082). Eur J Pharmacol (2007) 0.82
Mechanisms involved in the antinociception induced by systemic administration of guanosine in mice. Br J Pharmacol (2010) 0.82
Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin. Nutrients (2014) 0.82
The analgesic action of morphine-n-oxide. Br J Pharmacol (1968) 0.82
Antinociceptive and antipyretic activities of amaranthus viridis linn in different experimental models. Avicenna J Med Biotechnol (2009) 0.81
Analgesic activity of the ethanolic extract of Shorea robusta resin in experimental animals. Indian J Pharmacol (2012) 0.81
The role of G-protein receptor 84 in experimental neuropathic pain. J Neurosci (2015) 0.81
Antinociceptive and cytotoxic activities of an epiphytic medicinal orchid: Vanda tessellata Roxb. BMC Complement Altern Med (2014) 0.81
Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms. Brain Res (2008) 0.81
New approaches to clarify antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves. Int J Mol Sci (2011) 0.81
Comparison of the dose-response effects of morphine on brain amines, analgesia and activity in mice. Br J Pharmacol (1972) 0.81
Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse. Korean J Physiol Pharmacol (2012) 0.81
Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels. PLoS One (2013) 0.80
Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats. Evid Based Complement Alternat Med (2014) 0.80
Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.80
Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monniera. Int J Ayurveda Res (2011) 0.80
Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.80
Bioactivity studies on Musa seminifera Lour. Pharmacogn Mag (2013) 0.80
Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Mol Neuropsychiatry (2016) 0.79
Anti-inflammatory, analgesic, and antioxidant activities of methanolic wood extract of Pterocarpus santalinus L. J Pharmacol Pharmacother (2011) 0.79
Antinociceptive activity of furan-containing congeners of improgan and ranitidine. Bioorg Med Chem Lett (2007) 0.79
Behavioral effects of urotensin-II centrally administered in mice. Psychopharmacology (Berl) (2005) 0.79
Mechanisms of analgesic and anti-inflammatory properties of Annona muricata Linn. (Annonaceae) fruit extract in rodents. J Med Food (2014) 0.79
Antinociceptive properties of thyrotropin releasing hormone in mice: comparison with morphine. Br J Pharmacol (1983) 0.79
Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice. Pharmacol Biochem Behav (2006) 0.79
Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham. BMC Complement Altern Med (2014) 0.79
Antinociceptive activity and effect of methanol extracts of three salvia spp. On withdrawal syndrome in mice. Adv Pharm Bull (2013) 0.79
Vanda roxburghii: an experimental evaluation of antinociceptive properties of a traditional epiphytic medicinal orchid in animal models. BMC Complement Altern Med (2015) 0.79
Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mice. Psychopharmacology (Berl) (2004) 0.79
Evaluation of antinociceptive effects of Tragia plukenetii: A possible mechanism. Ayu (2013) 0.79
EXPRESS: Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury-model mice via suppression of TNF-α expression in the spinal cord. Mol Pain (2016) 0.78
Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds. Evid Based Complement Alternat Med (2015) 0.78
Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine. Neuropsychopharmacology (2015) 0.78
Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs. Eur J Pharmacol (2010) 0.78
Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties. Psychopharmacology (Berl) (2014) 0.78
Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics. Proc Natl Acad Sci U S A (1998) 0.78
Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves. Int J Mol Sci (2010) 0.78
Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment. Int J Neuropsychopharmacol (2016) 0.78
Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice. Int J Mol Sci (2015) 0.78
Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities. Saudi Pharm J (2011) 0.78
Alpha-methyldopa induces a naltrexone-insensitive antinociception and hypomotility in rats. Br J Pharmacol (1990) 0.77
Effects of silymarin on neuropathic pain and formalin-induced nociception in mice. Iran J Basic Med Sci (2015) 0.77
Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice. Addict Biol (2009) 0.77
Synthetic substances with morphine-like effect; relationship between analgesic action and addiction liability, with a discussion of the chemical structure of addiction-producing substances. Bull World Health Organ (1956) 3.60
Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability. Bull World Health Organ (1957) 2.74
Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action. Bull World Health Organ (1955) 1.80
Tests for addiction (chronic intoxication) of morphine type. Bull World Health Organ (1963) 1.58
Synthetic analgesics; methadone isomers and derivatives. J Pharmacol Exp Ther (1950) 1.19
Synthetic analgesics: III. Methadols, isomethadols, and their acyl derivatives. J Pharmacol Exp Ther (1954) 0.98
Compounds related to pethidine-IV. New general chemical methods of increasing the analgesic activity of pethidine. J Med Pharm Chem (1960) 0.92
Addiction-producing versus habit-forming. J Am Med Assoc (1957) 0.91
The analgesic equivalence to morphine and relative side action liability of oxymorphone (14-hydroxydihydro morphinone). J Pharmacol Exp Ther (1959) 0.90
The search for new analgesics. J Chronic Dis (1956) 0.88
The relation of chemical structure to analgesic action. J Am Pharm Assoc Am Pharm Assoc (1950) 0.82
A new potent analgetic antagonist. Nature (1961) 0.81
Survey of antimalarial agents: chemotherapy of Plasmodium gallinaceum infections; toxicity; correlation of structure and action. Public Health Monogr (1953) 0.80
[Physical dependence and tolerance in relation to various analgesics in patients suffering from chronic pains; comparison between morphine, oxymorphone and anileridine]. Bull World Health Organ (1959) 0.80
Metopon hydrochloride (methyldihydromorphinone hydrochloride). Can Med Assoc J (1948) 0.77
Addiction liability and narcotics control. Public Health Rep (1959) 0.76
Pharmacology of metopon and other new analgesic opium derivatives. Ann N Y Acad Sci (1948) 0.76
Metopon hydrochloride: an experiment in clinical evaluation. Public Health Rep (1949) 0.75
NEW BENZOMORPHAN ANALGETICS. J Med Pharm Chem (1962) 0.75
Metopon. J Am Pharm Assoc Am Pharm Assoc (Baltim) (1947) 0.75
Progress in drug therapy of pain. Am Prof Pharm (1948) 0.75
[Not Available]. Krebsarzt (1949) 0.75
THE RANGE OF VISUAL SEARCH (FINAL REPORT). TECHN DOCUM REP NO. ESD-TDR-64-535. Tech Doc Rep U S Air Force Syst Command Electron Syst Div (1964) 0.75
A new morphine-like analgesic. J Am Pharm Assoc Am Pharm Assoc (Baltim) (1947) 0.75
Newer narcotics. Am Pract Dig Treat (1948) 0.75
Addiction liability of analgesics: tests and results. J Am Geriatr Soc (1956) 0.75