Published in J Mol Biol on February 20, 1992
Combining conformational flexibility and continuum electrostatics for calculating pK(a)s in proteins. Biophys J (2002) 3.44
Comparative sequence analysis of ribonucleases HII, III, II PH and D. Nucleic Acids Res (1997) 2.56
Lessons in stability from thermophilic proteins. Protein Sci (2006) 1.88
Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. EMBO J (1997) 1.75
Binding and cleavage specificities of human Argonaute2. J Biol Chem (2009) 1.45
A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins. Biophys J (1999) 1.44
Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes. Biochem J (1995) 1.39
Equilibrium unfolding of Escherichia coli ribonuclease H: characterization of a partially folded state. Protein Sci (1994) 1.36
Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase. Proc Natl Acad Sci U S A (1995) 1.29
Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin. PLoS Comput Biol (2009) 1.26
Protein side-chain dynamics and residual conformational entropy. J Am Chem Soc (2009) 1.25
Structural distribution of stability in a thermophilic enzyme. Proc Natl Acad Sci U S A (1999) 1.22
Conserved quantitative stability/flexibility relationships (QSFR) in an orthologous RNase H pair. Proteins (2006) 1.16
A common 40 amino acid motif in eukaryotic RNases H1 and caulimovirus ORF VI proteins binds to duplex RNAs. Nucleic Acids Res (1998) 1.14
NMR structure determination of the hypothetical protein TM1290 from Thermotoga maritima using automated NOESY analysis. J Biomol NMR (2004) 1.13
Sequence-specific cleavage of small-subunit (SSU) rRNA with oligonucleotides and RNase H: a rapid and simple approach to SSU rRNA-based quantitative detection of microorganisms. Appl Environ Microbiol (2004) 1.09
Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering. J Biol Chem (1993) 1.09
Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses. Protein Sci (2001) 1.08
Interpreting protein structural dynamics from NMR chemical shifts. J Am Chem Soc (2012) 1.08
Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI. Protein Sci (2000) 1.07
Crystal structure of the moloney murine leukemia virus RNase H domain. J Virol (2006) 1.04
Increasing protein stability by improving beta-turns. Proteins (2009) 1.03
Folding of an isolated ribonuclease H core fragment. Protein Sci (1999) 1.00
Identification of the first archaeal Type 1 RNase H gene from Halobacterium sp. NRC-1: archaeal RNase HI can cleave an RNA-DNA junction. Biochem J (2004) 0.94
Structure, stability, and folding of ribonuclease H1 from the moderately thermophilic Chlorobium tepidum: comparison with thermophilic and mesophilic homologues. Biochemistry (2009) 0.94
Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1. Nucleic Acids Res (2002) 0.94
Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase. Virus Res (2008) 0.92
Characterization of a folding intermediate from HIV-1 ribonuclease H. Protein Sci (1998) 0.89
Thermal adaptation of conformational dynamics in ribonuclease H. PLoS Comput Biol (2013) 0.86
Effects of 5-(N-aminohexyl)carbamoyl-2'-deoxyuridine on endonuclease stability and the ability of oligodeoxynucleotide to activate RNase H. Nucleic Acids Res (1997) 0.85
Crystallization and preliminary X-ray analysis of Escherichia coli RNase HI-dsRNA complexes. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.84
Binding of nucleic acids to E. coli RNase HI observed by NMR and CD spectroscopy. Nucleic Acids Res (1993) 0.84
Side chain dynamics of carboxyl and carbonyl groups in the catalytic function of Escherichia coli ribonuclease H. J Am Chem Soc (2013) 0.82
Identification of residual structure in the unfolded state of ribonuclease H1 from the moderately thermophilic Chlorobium tepidum: comparison with thermophilic and mesophilic homologues. Biochemistry (2010) 0.82
Histidine in continuum electrostatics protonation state calculations. Proteins (2011) 0.81
Insights into the structure and activity of prototype foamy virus RNase H. Retrovirology (2012) 0.80
Evidence from molecular dynamics simulations of conformational preorganization in the ribonuclease H active site. F1000Res (2014) 0.80
Crystallization and preliminary X-ray diffraction study of thermostable RNase HIII from Bacillus stearothermophilus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.80
Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability. Protein Sci (2015) 0.79
Non-native structure appears in microseconds during the folding of E. coli RNase H. J Mol Biol (2014) 0.78
Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins. BMC Evol Biol (2010) 0.78
Chemically accurate protein structures: validation of protein NMR structures by comparison of measured and predicted pKa values. J Biomol NMR (2006) 0.78
Protein unfolding under force: crack propagation in a network. Biophys J (2011) 0.77
Autonomously folding protein fragments reveal differences in the energy landscapes of homologous RNases H. PLoS One (2015) 0.76
Conformational preferences underlying reduced activity of a thermophilic ribonuclease H. J Mol Biol (2014) 0.76
Performance of ZDOCK and IRAD in CAPRI rounds 28-34. Proteins (2016) 0.75
Adaptive amino acid replacements accompanied by domain fusion in reverse transcriptase. J Mol Evol (1997) 0.75
Comprehensive study on iterative algorithms of multiple sequence alignment. Comput Appl Biosci (1995) 8.39
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature (2000) 6.58
Long survival in rats after multivisceral versus isolated small-bowel allotransplantation under FK 506. Surgery (1991) 5.92
A ras-related gene with transformation suppressor activity. Cell (1989) 5.81
Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc (1974) 5.53
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions. J Biol Chem (1985) 4.44
Identification of the heme compound copurified with deoxyribonucleic acid (DNA) from bloodstains, a major inhibitor of polymerase chain reaction (PCR) amplification. J Forensic Sci (1994) 4.02
Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell (1994) 3.74
Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+. Cell (1990) 3.67
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem (1999) 3.67
Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol (1986) 3.66
Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell (1997) 3.30
Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res (1986) 3.17
Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. Proc Natl Acad Sci U S A (1985) 3.01
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01
Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature (1976) 3.00
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem (1991) 2.89
Genetic evidence for female host-specific races of the common cuckoo. Nature (2000) 2.84
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage. Mol Microbiol (2000) 2.77
Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation (1995) 2.70
Cupric oxide as an induced-multiferroic with high-TC. Nat Mater (2008) 2.67
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach. Nucleic Acids Res (1986) 2.64
Expression of bacterial chloramphenicol acetyltransferase gene in tobacco plants mediated by TMV-RNA. EMBO J (1987) 2.61
Three-dimensional structure of ribonuclease H from E. coli. Nature (1990) 2.58
In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus. Nucleic Acids Res (1986) 2.58
Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. BJOG (2014) 2.56
Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli. Cell (1994) 2.55
Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit analysis. Nat Cell Biol (2001) 2.53
Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec (2000) 2.44
Treatment of hemoptysis patients by thrombin and fibrinogen-thrombin infusion therapy using a fiberoptic bronchoscope. Chest (1989) 2.36
Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition. Cell (1995) 2.36
In vitro transcription of infectious RNAs from full-length cDNAs of tobacco mosaic virus. Proc Natl Acad Sci U S A (1986) 2.35
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest (1992) 2.33
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis (2000) 2.32
Joining of ribooligonucleotides with T4 RNA ligase and identification of the oligonucleotide-adenylate intermediate. Nucleic Acids Res (1976) 2.31
Acriflavine-binding capacity of Escherichia coli in relation to acriflavine sensitivity and metabolic activity. J Bacteriol (1966) 2.28
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating. Mol Cell Biol (1994) 2.25
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med (1986) 2.25
The nucleotide sequences of copia and copia-related RNA in Drosophila virus-like particles. Nature (1985) 2.23
Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core. Proc Natl Acad Sci U S A (1992) 2.23
Surface of bacteriorhodopsin revealed by high-resolution electron crystallography. Nature (1997) 2.22
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet (1997) 2.20
Interaction of endostatin with integrins implicated in angiogenesis. Proc Natl Acad Sci U S A (2001) 2.19
Diffusion-weighted imaging of metastatic brain tumors: comparison with histologic type and tumor cellularity. AJNR Am J Neuroradiol (2006) 2.17
Crazy-paving appearance at thin-section CT: spectrum of disease and pathologic findings. Radiology (1999) 2.16
DNA sequence of the gene coding for Escherichia coli ribonuclease H. J Biol Chem (1983) 2.15
N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest (2000) 2.13
Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis. J Biol Chem (1990) 2.12
Genetic determination of resistance to acriflavine, phenethyl alcohol, and sodium dodecyl sulfate in Escherichia coli. J Bacteriol (1968) 2.11
Protein Synthesis in Bromegrass (Bromus inermis Leyss) Cultured Cells during the Induction of Frost Tolerance by Abscisic Acid or Low Temperature. Plant Physiol (1987) 2.09
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem (2001) 2.08
A gene controlling the synthesis of non specific alkaline phosphatase in Saccharomyces cerevisiae. Biochim Biophys Acta (1976) 2.04
NMR studies of a DNA containing 8-hydroxydeoxyguanosine. Nucleic Acids Res (1991) 2.03
Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst (1990) 2.00
Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol (1999) 2.00
Idiopathic interstitial pneumonias: diagnostic accuracy of thin-section CT in 129 patients. Radiology (1999) 1.99
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem (1999) 1.99
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. EMBO J (1992) 1.98
Identification and characterization of a host protein required for efficient template selection in viral RNA replication. Proc Natl Acad Sci U S A (2000) 1.98
Structure of a replication-terminator protein complexed with DNA. Nature (1996) 1.97
MASCOT: multiple alignment system for protein sequences based on three-way dynamic programming. Comput Appl Biosci (1993) 1.97
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell (1995) 1.96
Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus. Protein Sci (2001) 1.94
Causes of maternal mortality in Japan. JAMA (2000) 1.92
Insertion of a 5' truncated L1 element into the 3' end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy. J Clin Invest (1993) 1.92
Solid phase synthesis of oligoribonucleotides using the o-nitrobenzyl group for 2'-hydroxyl protection and H-phosphonate chemistry. Nucleic Acids Res (1987) 1.91
Formation of brome mosaic virus RNA-dependent RNA polymerase in yeast requires coexpression of viral proteins and viral RNA. Proc Natl Acad Sci U S A (1995) 1.90
Novel nonsense mutation in the Na+/HCO3- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma. J Am Soc Nephrol (2001) 1.90
Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88
Synthesis, structural characterization and antimicrobial activities of 4- and 6-coordinate nickel(II) complexes with three thiosemicarbazones and semicarbazone ligands. J Inorg Biochem (2001) 1.87
Nature of the charge distribution in proteins. Nature (1981) 1.85
Recovery from "hepatorenal syndrome" after orthotopic liver transplantation. N Engl J Med (1973) 1.85
Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. J Exp Med (1999) 1.84
A novel pathophysiologic phenomenon in cachexic patients with chronic obstructive pulmonary disease: the relationship between the circadian rhythm of circulating leptin and the very low-frequency component of heart rate variability. Am J Respir Crit Care Med (2001) 1.83
The complete nucleotide sequence of phi CTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: implications for phage evolution and horizontal gene transfer via bacteriophages. Mol Microbiol (1999) 1.83
Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives. J Med Chem (1984) 1.83
Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus. EMBO J (2001) 1.81
Hereditary amyotrophic lateral sclerosis. Histochemical and electron microscopic study of hyaline inclusions in motor neurons. Arch Neurol (1972) 1.81
Essential structure of E. coli promoter: effect of spacer length between the two consensus sequences on promoter function. Nucleic Acids Res (1983) 1.80
The NPK1 mitogen-activated protein kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis. Genes Dev (2001) 1.79
A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes. J Immunol (1987) 1.79
Fluorescence energy transfer between Ca2+ transport ATPase molecules in artificial membranes. Biochemistry (1977) 1.78
Prediction of hyperbilirubinemia in near-term and term infants. Pediatrics (2001) 1.77
Correlation between 25-hydroxyvitamin D3 1 alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med (2001) 1.77
The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2000) 1.77
The subtypes of localized bronchioloalveolar carcinoma: CT-pathologic correlation in 18 cases. AJR Am J Roentgenol (1999) 1.76
Recent developments in the chemical synthesis of polynucleotides. Nucleic Acids Res (1982) 1.76