Parental age and mutation.

Formal genetics of muscular dystrophy. Am J Hum Genet (1959) 6.03

A study of major congenital defects in Japanese infants. Am J Hum Genet (1958) 6.01

Advanced parental age and the risk of autism spectrum disorder. Am J Epidemiol (2008) 3.30

Congenital Aniridia. Am J Hum Genet (1960) 2.50

Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome. Am J Hum Genet (2000) 1.85

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci U S A (2006) 1.80

Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am J Hum Genet (2012) 1.78

Cleft lip and palate: seasonal incidence, birth weight, birth rank, sex, site, associated malformations and parental age. A statistical survey. Arch Dis Child (1961) 1.76

Paternal factors and schizophrenia risk: de novo mutations and imprinting. Schizophr Bull (2001) 1.75

Paternal age and risk of schizophrenia in adult offspring. Am J Psychiatry (2002) 1.69

Sporadic cases of hemophilia and the question of a possible sex difference in mutation rates. Am J Hum Genet (1962) 1.67

Recurrence risks for germinal mosaics. Am J Hum Genet (1971) 1.65

Elevated germline mutation rate in teenage fathers. Proc Biol Sci (2015) 1.51

Male biological clock: a critical analysis of advanced paternal age. Fertil Steril (2015) 1.51

Paternal age and the occurrence of birth defects. Am J Hum Genet (1986) 1.50

Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study. Br J Cancer (2003) 1.46

Characterization of five partial deletions of the factor VIII gene. Proc Natl Acad Sci U S A (1987) 1.45

On the parental origin of de novo mutation in man. J Med Genet (1991) 1.40

Hardy, Weinberg and language impediments. Genetics (1999) 1.40

A genetic study of torsion dystonia. J Med Genet (1975) 1.37

The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet (2003) 1.37

Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia. Proc Natl Acad Sci U S A (2005) 1.35

The effect of parental age on rates of mutation for hemophilia and evidence for differing mutation rates for hemophilia A and B. Am J Hum Genet (1968) 1.27

Parental age in acondroplasia and mongolism. Am J Hum Genet (1957) 1.20

A family study of coarctation of the aorta. J Med Genet (1976) 1.17

Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Reprod Biol Endocrinol (2005) 1.02

Evidence against the structural gene encoding type II collagen (COL2A1) as the mutant locus in achondroplasia. J Med Genet (1986) 1.00

EFFECTS OF FATHER'S AGE ON THE RISK OF CHILD HANDICAP OR DEATH. Am J Hum Genet (1965) 0.99

Ageing of the male germ line. Nat Rev Urol (2013) 0.99

Maternal age and birth order as indices of environmental influence. Am J Hum Genet (1956) 0.99

Base excision repair, aging and health span. Mech Ageing Dev (2008) 0.97

Parents' ages at birth and risk of adult-onset hematologic malignancies among female teachers in California. Am J Epidemiol (2010) 0.94

De novo mutations from sporadic schizophrenia cases highlight important signaling genes in an independent sample. Schizophr Res (2015) 0.93

The effects of advanced paternal age on fertility. Asian J Androl (2013) 0.93

Interpreting the Dependence of Mutation Rates on Age and Time. PLoS Biol (2016) 0.93

Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome. Am J Hum Genet (2004) 0.92

Paternal age increases the risk for autism in an Iranian population sample. Mol Autism (2010) 0.92

Familial predisposition to recurrent mutations causing Huntington's disease: genetic risk to sibs of sporadic cases. J Med Genet (1993) 0.92

Advanced paternal age and reproductive outcome. Asian J Androl (2011) 0.90

Parental age, genetic mutation, and cerebral palsy. J Med Genet (1993) 0.89

Life history effects on the molecular clock of autosomes and sex chromosomes. Proc Natl Acad Sci U S A (2016) 0.88

Increased paternal age and the influence on burden of genomic copy number variation in the general population. Hum Genet (2013) 0.88

Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability. J Intellect Disabil Res (2004) 0.87

Hypoplastic left heart complex. J Med Genet (1967) 0.85

Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer. Asian J Androl (2016) 0.84

Lionel Sharples Penrose, 1898-1972: A personal memoir in celebration of the centenary of his birth. Genetics (1998) 0.84

History of Our Understanding of the Causes of Congenital Heart Disease. Circ Cardiovasc Genet (2015) 0.83

Parental age effects on cortical morphology in offspring. Cereb Cortex (2011) 0.83

Advanced paternal age increases the risk of schizophrenia and obsessive-compulsive disorder in a Chinese Han population. Psychiatry Res (2012) 0.80

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reprod Biol Endocrinol (2015) 0.80

Paternal age and offspring congenital heart defects: a national cohort study. PLoS One (2015) 0.79

Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia. Ann N Y Acad Sci (2010) 0.79

Hypochondroplasia. Arch Dis Child (1978) 0.77

Paternal age and psychiatric disorders: A review. Am J Med Genet B Neuropsychiatr Genet (2016) 0.77

Birth order and the genetics of amyotrophic lateral sclerosis. J Neurol (2007) 0.76

Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice. Mutat Res (2012) 0.76

Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers. Annu Rev Genomics Hum Genet (2016) 0.76

Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice. Mutat Res (2015) 0.75

Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals. PLoS One (2016) 0.75

Central nervous system haemangioblastoma: a clinical and genetic study of 52 cases. J Neurol Neurosurg Psychiatry (1990) 0.75

Parent-of-origin effects in SOX2 anophthalmia syndrome. Mol Vis (2011) 0.75

The general purpose sibpair linkage test. Ann Eugen (1953) 11.81

Monozygotic and dizygotic twin diagnosis. Ann Hum Genet (1955) 4.95

Birth weight and gestation time in relation to maternal age, parity and infant survival. Ann Eugen (1951) 4.06

The chromosomes in a patient showing both mongolism and the Klinefelter syndrome. Lancet (1959) 4.06

Genetics of anencephaly. J Ment Defic Res (1957) 2.93

The distal triradius t on the hands of parents and sibs of mongol imbeciles. Ann Hum Genet (1954) 2.51

Chromosomal translocations in mongolism and in normal relatives. Lancet (1960) 2.27

CHROMOSOME DELETION IN A CASE OF RETINOBLASTOMA. Ann Hum Genet (1963) 2.18

Heredity and environment in the causation of foetal malformation. Practitioner (1951) 2.14

Mongolism. Br Med Bull (1961) 2.13

Observations on the aetiology of mongolism. Lancet (1954) 2.12

Cystathioniuria. Ann Hum Genet (1959) 2.11

Measurement of pleiotropic effects in phenylketonuria. Ann Eugen (1951) 1.87

Impossible objects: a special type of visual illusion. Br J Psychol (1958) 1.85

The genetical background of common diseases. Acta Genet Stat Med (1953) 1.79

Maternal age in familial mongolism. J Ment Sci (1951) 1.77

A NOTE ON THE MEAN MEASUREMENTS OF HUMAN CHROMOSOMES. Ann Hum Genet (1964) 1.57

The interpupillary distance in mentally defective patients. Hum Biol (1954) 1.47

The supposed threat of declining intelligence. Am J Ment Defic (1948) 1.41

An aberrant small acrocentric chromosome. Ann Hum Genet (1962) 1.35

Mongolian idiocy (mongolism) and maternal age. Ann N Y Acad Sci (1954) 1.34

A note on the prevalence of genes for deleterious recessive traits in man. Ann Hum Genet (1957) 1.28

The Klinefeltermongolism type of double aneuploidy. Ann Hum Genet (1960) 1.26

A male with XXYY chromosomes. Ann Hum Genet (1961) 1.21

Parental age in acondroplasia and mongolism. Am J Hum Genet (1957) 1.20

Familial Langdon Down anomaly with chromosomal fusion. Ann Hum Genet (1961) 1.18

The incidence of mongolism in the general population. J Ment Sci (1949) 1.17

Data for the study of linkage in man; phenylketonuria and the ABO and MN loci. Ann Eugen (1951) 1.16

The blood typing of cases of mongolism, their parents and sibs. Ann Eugen (1953) 1.13

Reconsideration of the Lambert pedigree (ichthyosis hystrix gravior). Ann Hum Genet (1958) 1.12

Mutation in man. Acta Genet Stat Med (1957) 1.12

Enlarged satellites and multiple malformations in the same pedigree. Ann Hum Genet (1961) 1.11

Propagation of the unfit. Lancet (1950) 1.07

Paternal age in mongolism. Lancet (1962) 1.02

XERODERMA PIGMENTOSUM--ITS INHERITANCE AND RELATIONSHIP TO THE ABO BLOOD-GROUP SYSTEM. Ann Hum Genet (1965) 0.99

[Measurement of hypopigmentation in phenylpyruvic oligophrenia]. C R Seances Soc Biol Fil (1950) 0.98

Triploid cell cultures from a macerated foetus. Lancet (1961) 0.98

Distance, size and shape. Ann Eugen (1954) 0.98

Translocation and trisomic mongol sibs. Ann Hum Genet (1963) 0.95

Evidence of heterosis in man. Proc R Soc Lond B Biol Sci (1955) 0.93

A genetical study of human mammary cancer. Ann Eugen (1948) 0.92

The meaning of fitness in human populations. Ann Eugen (1949) 0.92

A genetical study of human mammary cancer. Br J Cancer (1948) 0.89

Data on the genetics of birth weight. Ann Eugen (1952) 0.88

The Galton laboratory; its work and aims. Eugen Rev (1949) 0.87

MEASUREMENTS OF LIKENESS IN RELATIVES OF TRISOMICS. Ann Hum Genet (1963) 0.86

Phenylketonuria; a problem in eugenics. Lancet (1946) 0.86

The problem of anticipation in pedigrees of dystrophia myotonica. Ann Eugen (1948) 0.85

On the stability of allelic systems, with special reference to haemoglobins A, S and C. Ann Hum Genet (1956) 0.81

Similarity of blood antigens in mother and mongol child. J Ment Defic Res (1957) 0.81

Mechanics of self-reproduction. Ann Hum Genet (1958) 0.81

Birth weight, gestation time and survival in sibs. Ann Eugen (1951) 0.78

Some notes on heredity counseling. Acta Genet Stat Med (1956) 0.78

DISTANCES WHICH INVOLVE SATELLITED CHROMOSOMES IN METAPHASE PREPARATIONS. Ann Hum Genet (1964) 0.76

The importance of statistics in psychiatry. Proc R Soc Med (1947) 0.76

Some clinical aspects of human cytogenetics. Postgrad Med J (1962) 0.75

Mental defect; recent researches. Br Med Bull (1946) 0.75

Chromosomes and disease. Trans Med Soc Lond (1960) 0.75

A theory of DNA replication. Ann Hum Genet (1960) 0.75

[Hereditary influence in the problem of adoptions]. Bol Oficina Sanit Panam (1954) 0.75

Genetic study of mammary cancer. Br Med J (1948) 0.75

Birth injury as a cause of mental defect; the statistical problem. J Ment Sci (1949) 0.75

Effects of radiation on the outcome of pregnancy. Public Health (1957) 0.75

Dilution of hair colour in phenylketonuria. Ann Eugen (1951) 0.75

Familial data on 144 cases of anencephaly, spina bifida and congenital hydrocephaly. Ann Eugen (1946) 0.75

GENETICAL ASPECTS OF HUMAN INFERTILITY. Proc R Soc Lond B Biol Sci (1963) 0.75

Discussion on implications of recent genetic research in psychiatry. Proc R Soc Med (1961) 0.75

The pattern perception test; experimental results. Br J Med Psychol (1946) 0.75

The mutational origin of hereditary eye diseases. Bibl Ophthalmol (1957) 0.75

Asearch for linkage between the A,B,C agglutinogens and phenylketonuria. Am J Ment Defic (1945) 0.75

Inheritance of zygodactyly. J Hered (1946) 0.75

Hereditary influences in relation to the problem of child adoption. Bull World Health Organ (1953) 0.75

World frequencies of the O, A and B blood group genes. Ann Eugen (1951) 0.75

Hereditary influences. Med Illus (1951) 0.75

Some notes on discrimination. Ann Eugen (1947) 0.75

Data for the study of linkage in man: red hair and the ABO locus. Ann Eugen (1950) 0.75

[Principles of frequency of genes and its stability in human population]. J Genet Hum (1954) 0.75

Value of genetics in medicine. Br Med J (1950) 0.75

Moral deficiency. J Ment Sci (1947) 0.75

A contribution to the genetics of hair colour in man. Ann Eugen (1946) 0.75

Garrod's conception of inborn error and its development. Biochem J (1949) 0.75

Two pedigrees of ectrodactyly. Ann Eugen (1951) 0.75

SOME FORMAL CONSEQUENCES OF GENES IN STABLE EQUILIBRIUM. Ann Hum Genet (1964) 0.75

On the familial appearances of maternal and foetal incompatibility. Ann Eugen (1946) 0.75

Social aspects of psychiatry; the importance of statistics. J Ment Sci (1946) 0.75

A further note on the sib-pair linkage method. Ann Eugen (1946) 0.75

ON MEASURING THE SIZE OF THE HEAD. J Ment Defic Res (1964) 0.75