Published in Ann N Y Acad Sci on November 30, 1992
Modulation of the Na,K-pump function by beta subunit isoforms. J Gen Physiol (1994) 1.28
Brain Na(+), K(+)-ATPase Activity In Aging and Disease. Int J Biomed Sci (2014) 0.86
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature (1994) 9.76
CFTR as a cAMP-dependent regulator of sodium channels. Science (1995) 6.50
Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (1993) 6.04
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet (1996) 4.15
An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature (1997) 3.87
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J (2001) 3.43
Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci U S A (1996) 3.37
Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line. J Am Soc Nephrol (1999) 2.88
A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci U S A (1995) 2.69
Membrane topology of the epithelial sodium channel in intact cells. Am J Physiol (1994) 2.69
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J (1996) 2.39
The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J (1998) 2.34
Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol (2001) 2.28
Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry. J Cell Biol (1994) 2.18
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. J Clin Invest (1999) 2.15
Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J Gen Physiol (1998) 2.13
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol (2001) 2.13
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A (1995) 2.10
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. EMBO J (1994) 2.10
Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem (2000) 1.99
Epithelial sodium channels. Curr Opin Nephrol Hypertens (1994) 1.93
A role for the beta-subunit in the expression of functional Na+-K+-ATPase in Xenopus oocytes. Am J Physiol (1989) 1.92
Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney Int (2000) 1.67
The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells. Am J Physiol (1995) 1.65
Transcriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin. Proc Natl Acad Sci U S A (2001) 1.64
Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J Biol Chem (1997) 1.61
Aldosterone-induced increase in the abundance of Na+ channel subunits. Am J Physiol (1996) 1.59
Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line. J Am Soc Nephrol (2000) 1.58
Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets. Am J Physiol Renal Physiol (2000) 1.47
Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface. J Biol Chem (1999) 1.46
A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J (1997) 1.46
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J Clin Invest (1998) 1.45
Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. EMBO J (2001) 1.41
Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells. J Am Soc Nephrol (1997) 1.39
Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump. J Biol Chem (1992) 1.38
A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A (1997) 1.37
Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone. J Comp Neurol (1999) 1.37
Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel. Proc Natl Acad Sci U S A (1999) 1.33
Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene. J Clin Invest (1996) 1.30
A mouse model for Liddle's syndrome. J Am Soc Nephrol (1999) 1.30
The gamma subunit is a specific component of the Na,K-ATPase and modulates its transport function. EMBO J (1997) 1.28
Modulation of the Na,K-pump function by beta subunit isoforms. J Gen Physiol (1994) 1.28
Role of beta-subunit domains in the assembly, stable expression, intracellular routing, and functional properties of Na,K-ATPase. J Biol Chem (1998) 1.27
A conformation of Na(+)-K+ pump is permeable to proton. Am J Physiol (1995) 1.25
Lung epithelial Na channel subunits are differentially regulated during development and by steroids. Am J Physiol (1995) 1.21
Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases. Am J Physiol (1999) 1.21
Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes. J Physiol (1999) 1.20
Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways. Am J Physiol (1995) 1.19
Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation. J Biol Chem (1994) 1.19
CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit. EMBO J (2001) 1.18
Hormonal regulation of (Na+,K+)-ATPase biosynthesis in the toad bladder. Effect of aldosterone and 3,5,3'-triiodo-L-thyronine. J Biol Chem (1982) 1.18
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. EMBO J (1992) 1.17
Aldosterone regulation of gene transcription leading to control of ion transport. Hypertension (1992) 1.17
Processing, intracellular transport, and functional expression of endogenous and exogenous alpha-beta 3 Na,K-ATPase complexes in Xenopus oocytes. J Biol Chem (1992) 1.15
Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4. FEBS Lett (2000) 1.15
Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells. Am J Physiol (1989) 1.09
Membrane insertion of alpha- and beta-subunits of Na+,K+-ATPase. J Biol Chem (1985) 1.07
IGF-1 vs insulin: respective roles in modulating sodium transport via the PI-3 kinase/Sgk1 pathway in a cortical collecting duct cell line. Kidney Int (2006) 1.06
Regulation by aldosterone of Na+,K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells. J Cell Biol (1987) 1.06
Structure of the 5th transmembrane segment of the Na,K-ATPase alpha subunit: a cysteine-scanning mutagenesis study. FEBS Lett (2000) 1.06
Expression of the epithelial Na+ channel in the developing rat lung. Am J Physiol (1993) 1.06
Structure-function relationship of Na,K-ATPase. Annu Rev Physiol (1991) 1.04
Coexpression of alpha 1 with putative beta 3 subunits results in functional Na+/K+ pumps in Xenopus oocytes. Proc Natl Acad Sci U S A (1991) 1.04
Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps. J Cell Biol (1993) 1.03
Identification of a highly conserved sequence at the N-terminus of the epithelial Na+ channel alpha subunit involved in gating. Pflugers Arch (1999) 1.02
Structural and functional features of the transmembrane domain of the Na,K-ATPase beta subunit revealed by tryptophan scanning. J Biol Chem (2001) 1.01
Epithelial sodium channel regulatory proteins identified by functional expression cloning. Kidney Int Suppl (1998) 1.00
Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity. J Cell Biol (1992) 0.99
Immunochemical evidence for a transmembrane orientation of both the (Na+, K+)-ATPase subunits. Biochemistry (1981) 0.99
Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its alpha subunit. J Clin Invest (1999) 0.99
Developmental expression of sodium entry pathways in rat nephron. Am J Physiol (1999) 0.98
A putative H(+)-K(+)-ATPase is selectively expressed in surface epithelial cells of rat distal colon. Am J Physiol (1993) 0.96
The H,K-ATPase beta-subunit can act as a surrogate for the beta-subunit of Na,K-pumps. J Biol Chem (1991) 0.96
Novel isoforms of the beta and gamma subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing. Proc Natl Acad Sci U S A (1997) 0.96
Receptor occupancy vs. induction of Na+-K+-ATPase and Na+ transport by aldosterone. Am J Physiol (1985) 0.95
Amiloride-sensitive sodium channels in confluent M-1 mouse cortical collecting duct cells. J Membr Biol (1995) 0.95
Aldosterone induces a rapid increase in the rate of Na,K-ATPase gene transcription in cultured kidney cells. Mol Endocrinol (1989) 0.95
Effects of mineralocorticoids on Na+ and K+ excretion in the adrenalectomized rat. Am J Physiol (1983) 0.95
Salt- and angiotensin II-dependent variations in amiloride-sensitive rectal potential difference in mice. Clin Exp Pharmacol Physiol (2000) 0.94
Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance. J Biol Chem (1993) 0.94