Virus interference. I. The interferon.

Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06

A diverse range of gene products are effectors of the type I interferon antiviral response. Nature (2011) 12.86

Interferon-inducible antiviral effectors. Nat Rev Immunol (2008) 9.68

IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog (2008) 4.70

Activated STING in a vascular and pulmonary syndrome. N Engl J Med (2014) 4.67

Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55

The JAK-STAT pathway at twenty. Immunity (2012) 4.41

Type I interferon: friend or foe? J Exp Med (2010) 4.40

Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med (2004) 4.34

Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med (2000) 4.33

Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science (2013) 4.18

Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun (2010) 3.89

Immunomodulatory functions of type I interferons. Nat Rev Immunol (2012) 3.73

Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol (2010) 3.53

Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol (2014) 3.47

Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response. J Virol (2007) 3.04

Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state. J Virol (1999) 2.99

The role of interferon in influenza virus tissue tropism. J Virol (1998) 2.88

Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. Infect Immun (1973) 2.73

Herpes simplex virus ICP0 mutants are hypersensitive to interferon. J Virol (2000) 2.66

Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med (2006) 2.53

Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo. J Exp Med (2002) 2.47

West Nile virus infection and immunity. Nat Rev Microbiol (2013) 2.40

Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39

Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol (1998) 2.39

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc Natl Acad Sci U S A (1985) 2.33

HIV-1 immunopathogenesis: how good interferon turns bad. Clin Immunol (2006) 2.23

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. J Clin Invest (2010) 2.22

Inflammatory signals regulate hematopoietic stem cells. Trends Immunol (2011) 2.21

Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc Natl Acad Sci U S A (1973) 2.11

Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity. J Virol (2003) 2.10

Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection. Springer Semin Immunopathol (2006) 2.09

Interferome v2.0: an updated database of annotated interferon-regulated genes. Nucleic Acids Res (2012) 2.08

Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction. J Virol (2002) 2.08

The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN. J Virol (2000) 2.08

Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication. J Virol (2002) 2.04

Human leukocyte interferon: production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci U S A (1979) 2.03

AN INHIBITOR OF VIRAL ACTIVITY APPEARING IN INFECTED CELL CULTURES. Proc Natl Acad Sci U S A (1959) 2.01

Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A (1981) 1.98

Association of RIG-I with innate immunity of ducks to influenza. Proc Natl Acad Sci U S A (2010) 1.98

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis. Proc Natl Acad Sci U S A (2010) 1.94

Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proc Natl Acad Sci U S A (1980) 1.92

HIV and the chemokine system: 10 years later. EMBO J (2006) 1.88

Expression of the human fibroblast interferon gene in Escherichia coli. Proc Natl Acad Sci U S A (1980) 1.84

Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains. J Virol (2002) 1.81

Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol (2008) 1.79

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice. J Clin Invest (2011) 1.79

Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is unique. Proc Natl Acad Sci U S A (2002) 1.78

Studies on persistent infections of tissue cultures. III. Some quantitative aspects of host cell-virus interactions. J Exp Med (1958) 1.75

Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science (2013) 1.73

Dissecting interferon-induced transcriptional programs in human peripheral blood cells. PLoS One (2010) 1.73

Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission. Future Microbiol (2011) 1.72

Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev (2008) 1.68

Interferon associated retinopathy. Br J Ophthalmol (1998) 1.65

Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A (2012) 1.65

Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus. J Exp Med (1981) 1.64

Faecal excretion of adenovirus in a closed community. Br Med J (1961) 1.64

Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol (2007) 1.63

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J Virol (1996) 1.63

An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine. J Exp Med (1966) 1.63

Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61

Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis. Clin J Am Soc Nephrol (2010) 1.60

Regulation of effector and memory T-cell functions by type I interferon. Immunology (2011) 1.58

Evasion of host defenses by measles virus: wild-type measles virus infection interferes with induction of Alpha/Beta interferon production. J Virol (2000) 1.55

Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol (2005) 1.53

Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J Immunol (2010) 1.52

Biochemical basis for alterations in structure and function of HeLa cells infected with Newcastle disease virus. J Exp Med (1961) 1.52

Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial. J Infect Dis (2010) 1.51

Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model. J Infect Dis (2015) 1.50

Specificity of Interferon. Br Med J (1961) 1.50

STUDIES ON PERSISTENT INFECTIONS OF TISSUE CULTURES. V. THE INITIAL STAGES OF INFECTION OF L(MCN) CELLS BY NEWCASTLE DISEASE VIRUS. J Exp Med (1964) 1.45

Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oöcytes. Proc Natl Acad Sci U S A (1975) 1.44

SARS coronavirus and innate immunity. Virus Res (2007) 1.44

RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection. J Virol (1998) 1.44

Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines. J Virol (2006) 1.44

Interferon and transcription of early virus-specific RNA in cells infected with simian virus 40. Proc Natl Acad Sci U S A (1971) 1.43

Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J (2013) 1.41

Effect of interferon on the induction of human monocyte secretion of interleukin-1 activity. Immunology (1985) 1.40

Interferon induction with statolon in the intact animal. Bacteriol Rev (1967) 1.39

Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J Virol (2004) 1.39

ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. J Virol (2008) 1.38

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38

STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition. J Virol (2008) 1.37

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. Pharmacol Ther (2009) 1.37

Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells. EMBO J (1987) 1.37

Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov (2010) 1.36

Inhibition of cellular protein synthesis by double-stranded RNA: inactivation of an initiation factor. Proc Natl Acad Sci U S A (1973) 1.36

25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end. Nat Rev Immunol (2013) 1.35

The role of type I interferon production by dendritic cells in host defense. Biochimie (2007) 1.33

Interferon messenger RNA: translation in heterologous cells. Proc Natl Acad Sci U S A (1972) 1.32

Inborn errors of anti-viral interferon immunity in humans. Curr Opin Virol (2011) 1.31

Early alpha/beta interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88. J Virol (2005) 1.30

Amino acid sequence of a human leukocyte interferon. Proc Natl Acad Sci U S A (1981) 1.29

Cell-free synthesis of human interferon. Proc Natl Acad Sci U S A (1975) 1.29

Electrophoretically pure mouse interferon exerts multiple biologic effects. Proc Natl Acad Sci U S A (1979) 1.28

Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine. Clin Infect Dis (2012) 1.28

Cytokines in cancer immunotherapy. Cancers (Basel) (2011) 1.26

Variation in laboratory stocks of influenza viruses: biological characters of variants. Br J Exp Pathol (1950) 13.33

Variation in laboratory stocks of influenza viruses: genetic aspects of the variations. Br J Exp Pathol (1950) 12.62

Studies on vaccinia virus plaque formation and its inhibition by interferon. III. A simplified plaque inhibition assay of interferon. Virology (1963) 5.61

Influenza A viruses; laboratory studies, with special reference to European outbreak of 1950-1. Bull World Health Organ (1952) 3.91

Recent evolution and spread of strains of influenza-A virus. Lancet (1956) 3.76

Virus interference. II. Some properties of interferon. Proc R Soc Lond B Biol Sci (1957) 3.32

The spread of influenza; evidence from 1950-1951. Br Med J (1951) 3.19

THE RESISTANCE OF A2G MICE TO MYXOVIRUSES. J Immunol (1963) 3.00

Counts of influenza virus particles. J Gen Microbiol (1954) 2.98

Studies on the production, mode of action and properties of interferon. Br J Exp Pathol (1957) 2.61

Infection of volunteers with Asian influenza virus. Lancet (1957) 2.52

The use of V. cholerae filtrates in the destruction of non-specific inhibitor in ferret sera. Br J Exp Pathol (1951) 2.50

Influenza virus multiplication in the chick chorioallantoic membrane. J Gen Microbiol (1953) 2.44

The action of trypsin on normal serum inhibitors of influenza virus agglutination. Br J Exp Pathol (1953) 2.31

The influence of oxygenation of virus growth I. Effect on plaque formation by different viruses. Virology (1961) 2.18

Interference between inactive and active influenza viruses in the chick embryo. I. Quantitative aspects of interference. Aust J Exp Biol Med Sci (1950) 2.17

Administration of live influenza virus to volunteers. Lancet (1956) 2.11

INTERFERON. Adv Virus Res (1963) 1.98

Some factors affecting the production of interferon. Br J Exp Pathol (1958) 1.92

Role of interferon in recovery from virus infections. Lancet (1960) 1.84

Pathways of influenza spread. Lancet (1954) 1.81

Inhibition of virus multiplication by foreign nucleic acid. Nature (1963) 1.81

Multiplication of influenza virus under conditions of interference. Nature (1952) 1.76

Mode of action of interferon. Nature (1958) 1.67

Studies on vaccinia virus plaque formation and its inhibition by interferon. I. Dynamics of plaque formation by vaccinia virus. Virology (1963) 1.65

Interference in the chick chorion. J Gen Microbiol (1953) 1.64

Inhibition by interferon of the growth of vaccinia virus in the rabbit skin. Lancet (1959) 1.61

Protection of mice against the lethal action of an encephalitis virus. Br Med J (1960) 1.58

Particle counts of haemagglutinating viruses. J Gen Microbiol (1955) 1.58

Interference between inactive and active influenza viruses in the chick embryo. III. Inhibitor of virus haemagglutination in the chorioallantoic membrane. Aust J Exp Biol Med Sci (1950) 1.55

INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med (1964) 1.55

IMMUNITY TO TRANSPLANTABLE TUMORS FOLLOWING VIRAL ONCOLYSIS. I. MECHANISM OF IMMUNITY TO EHRLICH ASCITES TUMOR. J Immunol (1964) 1.51

Effect of interferon on the growth of viruses on the chick chorion. Br J Exp Pathol (1958) 1.49

The influence of oxygenation on virus growth. II. Effect on the antiviral action of interferon. Virology (1961) 1.46

Interference between inactive and active influenza viruses in the chick embryo. II. The site of interference. Aust J Exp Biol Med Sci (1950) 1.41

Influenza in an isolated community; an epidemic on Ocean Island. Lancet (1950) 1.35

Foreign nucleic acids as the stimulus to make interferon. Lancet (1963) 1.35

Antiviral action of interferon in embryonic cells. Lancet (1960) 1.33

Resistance of mice to mouse-adapted influenza A virus. Virology (1962) 1.33

Mechanism of recovery from viral infection in the chick embryo. Nature (1961) 1.32

The viruses of epidemic influenza. Br Med Bull (1953) 1.30

Metabolic effects of interferon on chick fibroblasts. Virology (1960) 1.29

[The viruses of the 1952-3 influenza epidemic]. Bull World Health Organ (1954) 1.27

Some properties of influenza virus filaments shown by electron microscopic particle counts. J Gen Microbiol (1954) 1.25

Interference between inactive and active influenza viruses in the chick embryo. Aust J Exp Biol Med Sci (1950) 1.16

The 1951 influenza viruses. Proc R Soc Med (1951) 1.16

The nucleic acid content of influenza virus. Biochim Biophys Acta (1957) 1.14

Optimal temperature for growth and sensitivity to interferon among different viruses. Virology (1963) 1.12

Growth of influenza virus in the chick chorion. Nature (1953) 1.09

Absence of interferon in lungs fom fatal cases of influenza. Br Med J (1962) 1.08

Particle counts and infectivity titrations for animal viruses. Adv Virus Res (1957) 1.05

Interferon production by different viruses. Virology (1963) 1.05

Viral interference and interferon. Br Med Bull (1959) 0.99

Studies on the mechanism of action of interferon. Virology (1961) 0.98

Antibodies to influenza viruses in the sera of Nigerians. J Hyg (Lond) (1957) 0.97

The effects of the acetic acid analogs of thyroxine and triiodothyronine on glycolysis in ascites tumor cells in vitro. Endocrinology (1955) 0.96

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A serological trail of Asian-influenza vaccine after the autumn epidemic. Lancet (1958) 0.94

P-Q variation in influenza viruses. Lancet (1953) 0.94

FOREIGN NUCLEIC ACIDS. Sci Am (1963) 0.93

Further studies on interferon. Br J Exp Pathol (1958) 0.93

Duration of protective action of interferon against infection with West Nile virus. Nature (1959) 0.92

Viral oncolysis with host survival. Proc Soc Exp Biol Med (1963) 0.92

The effect of adaptation to mice on the antigenicity of influenza virus. J Pathol Bacteriol (1953) 0.91

Neutralising action of human nasal secretions on neurotropic influenza virus. Br J Exp Pathol (1954) 0.89

Influence of increased oxygenation on influenza virus infection in mice. Lancet (1961) 0.89

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Interference between influenza and vaccinia viruses. Br J Exp Pathol (1954) 0.85

IMMUNITY TO TRANSPLANTABLE TUMORS FOLLOWING VIRAL ONCOLYSIS.II. ANTIGENIC SIMILARITIES BETWEEN THREE UNSPECIFIC MOUSE TUMORS. J Immunol (1965) 0.85

The structure of influenza virus filaments and spheres. J Gen Microbiol (1957) 0.83

The structure of viruses of the Newcastle disease-mumps-influenza (myxovirus) group. J Gen Microbiol (1957) 0.81

STUDIES ON INTERFERON. Aust J Exp Biol Med Sci (1965) 0.80

[The inactivated vaccinia antigen of Herrlich: an experiment in serological antigen testing in man]. Pathol Microbiol (Basel) (1962) 0.79

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Derivatives of 3:4-xylidine and related compounds as inhibitors of influenza virus: relationships between chemical structure and biological activity. Br J Pharmacol Chemother (1958) 0.75

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