Published in Clin Microbiol Rev on April 01, 2009
Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev (2014) 2.43
Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev (2010) 2.32
CpG DNA as a vaccine adjuvant. Expert Rev Vaccines (2011) 2.17
Recognition of herpesviruses by the innate immune system. Nat Rev Immunol (2011) 1.96
Functional IRF3 deficiency in a patient with herpes simplex encephalitis. J Exp Med (2015) 1.71
Th17 cytokines and the gut mucosal barrier. J Clin Immunol (2010) 1.64
Host-pathogen interactions made transparent with the zebrafish model. Curr Drug Targets (2011) 1.60
Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion. J Virol (2012) 1.54
Innate immune recognition and activation during HIV infection. Retrovirology (2010) 1.45
Tlr2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J (2009) 1.40
MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation. PLoS One (2016) 1.39
Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response. PLoS One (2015) 1.39
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta. Proc Natl Acad Sci U S A (2011) 1.36
Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J Virol (2013) 1.33
Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem (2014) 1.32
Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA. PLoS One (2012) 1.30
Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses doomed to extinction. Vet Res (2010) 1.27
Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles. J Virol (2010) 1.27
Modeling within-host dynamics of influenza virus infection including immune responses. PLoS Comput Biol (2012) 1.26
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol (2011) 1.24
IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care (2011) 1.23
Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses. Crit Rev Immunol (2010) 1.22
Lipocalin 2 is protective against E. coli pneumonia. Respir Res (2010) 1.19
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
Mycoplasma pneumoniae pneumonia in children. Korean J Pediatr (2012) 1.17
Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry (2012) 1.17
Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J Obes (2012) 1.16
Evasion of innate and adaptive immune responses by influenza A virus. Cell Microbiol (2010) 1.15
Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry. J Biol Chem (2013) 1.15
Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells. Immunol Cell Biol (2011) 1.14
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS. J Virol (2012) 1.13
Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda. BMC Immunol (2011) 1.12
Sleep and innate immunity. Front Biosci (Schol Ed) (2011) 1.11
Infection with conditionally virulent Streptococcus pneumoniae Δpab strains induces antibody to conserved protein antigens but does not protect against systemic infection with heterologous strains. Infect Immun (2011) 1.10
Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection. PLoS Pathog (2010) 1.10
The yeast-phase virulence requirement for α-glucan synthase differs among Histoplasma capsulatum chemotypes. Eukaryot Cell (2010) 1.09
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun (2012) 1.09
Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) (2013) 1.09
Pathogen recognition and activation of the innate immune response in zebrafish. Adv Hematol (2012) 1.07
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci (2015) 1.06
Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response. PLoS One (2010) 1.06
Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) hepatopancreas in response to Taura syndrome Virus (TSV) experimental infection. PLoS One (2013) 1.05
Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs. J Virol (2010) 1.04
Heart-kidney crosstalk and role of humoral signaling in critical illness. Crit Care (2014) 1.02
Kawasaki disease: laboratory findings and an immunopathogenesis on the premise of a "protein homeostasis system". Yonsei Med J (2012) 1.01
Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm. Cytokine (2009) 1.01
Toll-like receptors involved in the pathogenesis of experimental Candida albicans keratitis. Invest Ophthalmol Vis Sci (2009) 1.01
Innate immune evasion strategies of influenza viruses. Future Microbiol (2010) 1.00
Klebsiella pneumoniae outer membrane protein A is required to prevent the activation of airway epithelial cells. J Biol Chem (2011) 0.98
Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Mol Cell Proteomics (2012) 0.97
A review of bacteria-animal lateral gene transfer may inform our understanding of diseases like cancer. PLoS Genet (2013) 0.97
Retinal Muller glia initiate innate response to infectious stimuli via toll-like receptor signaling. PLoS One (2012) 0.97
Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective. J Cell Sci (2011) 0.96
Bunyaviruses and the type I interferon system. Viruses (2009) 0.96
Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription. Cell Rep (2013) 0.96
The psmα locus regulates production of Staphylococcus aureus alpha-toxin during infection. Infect Immun (2014) 0.96
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. J Biol Chem (2010) 0.95
Immunotherapeutic potential of extracellular vesicles. Front Immunol (2014) 0.94
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. PLoS Pathog (2014) 0.94
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses. PLoS Pathog (2015) 0.93
Intraspecies variation in the emergence of hyperinfectious bacterial strains in nature. PLoS Pathog (2012) 0.93
High-mobility group box-1 induces proinflammatory cytokines production of Kupffer cells through TLRs-dependent signaling pathway after burn injury. PLoS One (2012) 0.93
Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology (2014) 0.93
Both TLR2 and TRIF contribute to interferon-β production during Listeria infection. PLoS One (2012) 0.92
Innate immunity in diabetes and diabetic nephropathy. Nat Rev Nephrol (2015) 0.91
The human microbiome in hematopoiesis and hematologic disorders. Blood (2015) 0.91
Lipoteichoic acid and lipopolysaccharide can activate antimicrobial peptide expression in the tobacco hornworm Manduca sexta. Dev Comp Immunol (2010) 0.91
Antitumor Virotherapy by Attenuated Measles Virus (MV). Biology (Basel) (2013) 0.91
Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxide. J Biol Chem (2012) 0.90
Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncol Lett (2015) 0.90
Phleboviruses and the Type I Interferon Response. Viruses (2016) 0.90
Bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal applications. Front Immunol (2013) 0.90
Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect Immun (2015) 0.89
Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers. J Immunol (2011) 0.89
Human Cytokine-Induced Memory-Like Natural Killer Cells. J Innate Immun (2015) 0.89
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases. Clin Exp Immunol (2015) 0.89
Alcohol's Effect on Host Defense. Alcohol Res (2015) 0.89
Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages. Clin Exp Immunol (2011) 0.88
The pattern of cytokine production in vitro induced by ancient and modern Beijing Mycobacterium tuberculosis strains. PLoS One (2014) 0.88
Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chem Biol (2013) 0.87
Global effects of BKV infection on gene expression in human primary kidney epithelial cells. Virology (2009) 0.86
Exploring the influence of the gut microbiota and probiotics on health: a symposium report. Br J Nutr (2014) 0.86
FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J (2009) 0.86
In vitro immunomodulation of a whole blood IFN-γ release assay enhances T cell responses in subjects with latent tuberculosis infection. PLoS One (2012) 0.86
Toll-like receptors as novel therapeutic targets for ovarian cancer. ISRN Oncol (2012) 0.86
Oligodendroglia are limited in type I interferon induction and responsiveness in vivo. Glia (2012) 0.86
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis. J Cell Mol Med (2011) 0.86
Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. Biomed Res Int (2013) 0.86
A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma. J Transl Med (2014) 0.86
Clinically feasible approaches to potentiating cancer cell-based immunotherapies. Hum Vaccin Immunother (2015) 0.85
The role of innate immune pathways in type 1 diabetes pathogenesis. Curr Opin Endocrinol Diabetes Obes (2010) 0.85
The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host-pathogen interactions. Cell Microbiol (2015) 0.85
Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications. Biomed Res Int (2015) 0.85
Optimizing dendritic cell-based immunotherapy: tackling the complexity of different arms of the immune system. Mediators Inflamm (2012) 0.85
MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection. J Neuroinflammation (2011) 0.84
miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol (2014) 0.84
γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophages. J Nutr Biochem (2012) 0.84
Mytilus galloprovincialis myticin C: a chemotactic molecule with antiviral activity and immunoregulatory properties. PLoS One (2011) 0.84
Pathogen recognition and innate immunity. Cell (2006) 44.14
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Innate immune recognition. Annu Rev Immunol (2001) 26.65
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 23.92
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Nuclear factor-kappaB in cancer development and progression. Nature (2006) 18.31
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 17.42
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol (2003) 15.65
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell (2005) 14.20
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
The danger model: a renewed sense of self. Science (2002) 13.85
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature (2007) 13.56
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci (1957) 13.46
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 12.08
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
Dexamethasone in adults with bacterial meningitis. N Engl J Med (2002) 11.10
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature (2002) 11.05
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature (2008) 10.73
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity (2000) 10.34
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol (2004) 9.42
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
Regulation and function of IKK and IKK-related kinases. Sci STKE (2006) 8.98
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell (1997) 8.74
Meningococcal disease. N Engl J Med (2001) 8.50
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature (1999) 8.50
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol (2007) 8.33
Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem (1999) 7.81
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol (2000) 7.78
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J (1998) 7.20
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06
Innate immunity. N Engl J Med (2000) 7.03
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet (2006) 6.98
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell (2007) 6.84
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (1998) 6.69
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A (2005) 6.64
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol (1999) 6.60