Molecular characterization of interleukin 12.

Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med (1995) 6.89

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A (1997) 2.02

Interleukin-12 in infectious diseases. Clin Microbiol Rev (1997) 1.63

Intranasal immunization with recombinant Lactococcus lactis secreting murine interleukin-12 enhances antigen-specific Th1 cytokine production. Infect Immun (2003) 1.21

The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. Med Microbiol Immunol (2003) 1.03

Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol (2009) 1.01

Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells. Infect Immun (2008) 0.94

Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis. Arthritis Res (2000) 0.94

Interleukin 12: a new clinical player in cytokine therapy. Br J Cancer (1995) 0.90

Role of cytokine p40 family in multiple sclerosis. Minerva Med (2008) 0.85

The arthritogenic and immunostimulatory properties of phosphorothioate oligodeoxynucleotides rely on synergy between the activities of the nuclease-resistant backbone and CpG motifs. Inflammation (2004) 0.80

Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity. Immune Netw (2016) 0.75

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature (1985) 9.81

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature (1985) 7.22

An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels. Anal Biochem (1976) 7.00

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity (1996) 6.16

Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med (1993) 5.75

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem (1992) 5.60

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol (1998) 5.50

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J (1992) 5.23

Cloning and expression of murine IL-12. J Immunol (1992) 4.92

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1990) 4.60

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell (1990) 4.58

Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science (1986) 4.30

Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med (1993) 4.04

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med (1990) 3.93

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. J Immunol (1994) 3.50

Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry (1983) 3.49

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A (1996) 3.07

The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95

Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science (1986) 2.89

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol (1997) 2.86

Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol (2002) 2.82

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol (1996) 2.76

Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain. J Biomol NMR (1994) 2.72

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 2.68

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun (1998) 2.60

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol (1995) 2.57

Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector. Proc Natl Acad Sci U S A (1985) 2.46

Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol (1992) 2.37

Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol (1998) 2.36

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med (1995) 2.29

Recombinant human interleukin 1 alpha: purification and biological characterization. J Immunol (1986) 2.24

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol (1995) 2.21

Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci U S A (1986) 2.18

Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells. J Immunol (1986) 2.14

Two high-affinity interleukin 1 receptors represent separate gene products. Proc Natl Acad Sci U S A (1989) 2.13

Production of human c-myc protein in insect cells infected with a baculovirus expression vector. Mol Cell Biol (1985) 2.00

Increased axonal regeneration through a biodegradable amnionic tube nerve conduit: effect of local delivery and incorporation of nerve growth factor/hyaluronic acid media. Ann Plast Surg (2000) 1.99

Interleukin 12 at the site of disease in tuberculosis. J Clin Invest (1994) 1.98

IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol (1992) 1.92

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol (1994) 1.92

Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J Biol Chem (1983) 1.91

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J Immunol (1993) 1.90

Proteolytic processing of avian sarcoma and leukosis viruses pol-endo recombinant proteins reveals another pol gene domain. J Virol (1987) 1.85

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol (1994) 1.84

An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin. Science (1980) 1.81

Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest (1996) 1.79

Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol (1996) 1.79

IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J Immunol (1991) 1.78

Proliferation measurements with flow cytometry Tpot in cancer of the uterine cervix: correlation between two laboratories and preliminary clinical results. Int J Radiat Oncol Biol Phys (1995) 1.77

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens. J Immunol (1995) 1.76

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). J Exp Med (1992) 1.72

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences. Cytokine (1990) 1.72

Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs. J Immunol (1981) 1.71

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci U S A (1995) 1.71

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations. Proc Natl Acad Sci U S A (1994) 1.69

Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur J Immunol (1995) 1.68

Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes. Proc Natl Acad Sci U S A (1984) 1.68

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. J Immunol (1997) 1.66

IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol (1994) 1.65

Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme. Proc Natl Acad Sci U S A (1988) 1.64

Cimetidine in the treatment of herpesvirus infections. S Afr Med J (1980) 1.64

Putative enkephalin precursors in bovine adrenal medulla. Biochem Biophys Res Commun (1979) 1.63

Resolution and sensitivity of high field nuclear magnetic resonance spectroscopy. J Biomol NMR (2004) 1.60

Characterization of a factor(s) which synergizes with recombinant interleukin 2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro. Cell Immunol (1988) 1.56

Cloning and functional expression of a human heparanase gene. Biochem Biophys Res Commun (1999) 1.56

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Proc Natl Acad Sci U S A (1978) 1.53

Evolutionary relationships of vertebrate lactate dehydrogenase isozymes A4 (muscle), B4 (heart), and C4 (testis). J Biol Chem (1983) 1.53

cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+-ATPases. Proc Natl Acad Sci U S A (1988) 1.51

The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today (1995) 1.51

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling. J Biol Chem (1998) 1.51

Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity. Neuron (1993) 1.51

High affinity human IgE receptor (Fc epsilon RI). Analysis of functional domains of the alpha-subunit with monoclonal antibodies. J Biol Chem (1991) 1.49

The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer. Int J Hyperthermia (1996) 1.49

Sterile protection of monkeys against malaria after administration of interleukin-12. Nat Med (1997) 1.48

Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc Natl Acad Sci U S A (1990) 1.47

Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites. J Virol (1993) 1.47

Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum. Proc Natl Acad Sci U S A (1979) 1.47

Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia. Proc Natl Acad Sci U S A (1984) 1.47

Biochemical analysis of the transducin-phosphodiesterase interaction. Nat Struct Biol (1994) 1.46

Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol (1969) 1.46

Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg (1991) 1.46

Synergy between recombinant interleukin 2 (rIL 2) and IL 2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro. J Immunol (1986) 1.46

A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. Proc Natl Acad Sci U S A (1989) 1.44

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest (1992) 1.44

Role of endogenous tumor necrosis factor alpha and interleukin 1 for experimental tumor growth and the development of cancer cachexia. Cancer Res (1991) 1.44