Published in Cell Immunol on January 01, 1988
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1990) 4.60
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci U S A (1991) 4.48
Bladder Cancer Immunotherapy: BCG and Beyond. Adv Urol (2012) 1.27
Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology (2005) 1.25
Depressed interleukin-12 (IL-12), but not IL-18, production in response to a 30- or 32-kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis. Infect Immun (2000) 1.13
Intrathecal production of interleukin-12 and gamma interferon in patients with bacterial meningitis. Infect Immun (1997) 1.03
Interleukin 12: a new clinical player in cytokine therapy. Br J Cancer (1995) 0.90
The immunocytokine NHS-IL12 as a potential cancer therapeutic. Oncotarget (2014) 0.83
In vitro levels of interleukin 10 (IL-10) and IL-12 in response to a recombinant 32-kilodalton antigen of Mycobacterium bovis BCG after treatment for tuberculosis. Clin Vaccine Immunol (2008) 0.80
Effects of interferon-gamma and tumour necrosis factor-alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma. Clin Exp Immunol (1991) 0.79
The in vitro effects of interleukin-12 upon tumor-infiltrating lymphocytes derived from renal cell carcinoma. J Cancer Res Clin Oncol (1997) 0.75
Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice. Clin Exp Metastasis (1999) 0.75
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity (1996) 6.16
Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86
Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med (1993) 5.75
Serologic grouping of Cryptococcus neoformans. Proc Soc Exp Biol Med (1968) 4.97
Cloning and expression of murine IL-12. J Immunol (1992) 4.92
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1990) 4.60
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci U S A (1991) 4.48
Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med (1993) 4.04
Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med (1990) 3.93
Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. J Immunol (1994) 3.50
Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol (1991) 3.40
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A (1996) 3.07
Convenient assay for interferons. J Virol (1981) 2.95
Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol (1996) 2.76
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 2.68
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun (1998) 2.60
Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol (1995) 2.57
ON THE USE OF CHICK EMBRYO CULTURES OF INFLUENZA VIRUS IN COMPLEMENT FIXATION TESTS. Science (1940) 2.54
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature (1994) 2.29
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med (1995) 2.29
Recombinant human interleukin 1 alpha: purification and biological characterization. J Immunol (1986) 2.24
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol (1995) 2.21
Human leukocyte interferon: production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci U S A (1979) 2.03
Interleukin 12 at the site of disease in tuberculosis. J Clin Invest (1994) 1.98
IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol (1992) 1.92
Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol (1994) 1.92
Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proc Natl Acad Sci U S A (1980) 1.92
Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J Immunol (1993) 1.90
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities. Antimicrob Agents Chemother (1996) 1.86
Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol (1994) 1.84
Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest (1996) 1.79
Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol (1996) 1.79
IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J Immunol (1991) 1.78
Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci U S A (1995) 1.71
Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur J Immunol (1995) 1.68
Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. J Immunol (1997) 1.66
IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol (1994) 1.65
Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. J Biol Chem (1990) 1.57
A convenient and rapid cytopathic effect inhibition assay for interferon. Methods Enzymol (1981) 1.56
The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today (1995) 1.51
Sterile protection of monkeys against malaria after administration of interleukin-12. Nat Med (1997) 1.48
Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med (1988) 1.47
Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man. J Clin Invest (1972) 1.46
Synergy between recombinant interleukin 2 (rIL 2) and IL 2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro. J Immunol (1986) 1.46
Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann N Y Acad Sci (1996) 1.42
Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J Biol Chem (1992) 1.40
Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees. JAMA (1986) 1.39
Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the amino-terminal domain. J Biol Chem (1993) 1.38
IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J Immunol (1992) 1.32
Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man. Ann Hum Genet (1976) 1.29
Minorities and the medical profession: a historical perspective and analysis of current and future trends. J Natl Med Assoc (1986) 1.28
Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect Immun (1997) 1.25
Inhibition of host-cell protein and ribonucleic acid synthesis by Newcastle disease virus. J Virol (1968) 1.24
IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann N Y Acad Sci (1996) 1.24
Inhibition of gastric secretion in man by prostaglandin A. Gastroenterology (1971) 1.23
IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J Immunol (1996) 1.23
The role of cyclic AMP in gastric secretion. Ann N Y Acad Sci (1971) 1.19
Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo. Nat Biotechnol (1997) 1.19
IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease. J Immunol (1994) 1.18
IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int Immunol (1999) 1.18
In vitro susceptibility of Nocardia to antimicrobial agents. Antimicrob Agents Chemother (Bethesda) (1965) 1.17
Biological function and distribution of human interleukin-12 receptor beta chain. Eur J Immunol (1996) 1.17
Molecular characterization of interleukin 12. Arch Biochem Biophys (1992) 1.15
Effects of an orally administered prostaglandin analogue (16, 16-dimethyl prostaglandin E2) on human gastric secretion. Gastroenterology (1975) 1.14
Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur J Immunol (1997) 1.10
Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for two pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells. Cell Immunol (1976) 1.09
Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J Immunol (1998) 1.09
A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin. J Biol Chem (1990) 1.09
Clinical features of extracutaneous sporotrichosis. Medicine (Baltimore) (1967) 1.08
Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA. J Immunol Methods (1996) 1.07
Familial type IV hyperlipoproteinemia. N Engl J Med (1969) 1.07
Biochemical and functional analysis of soluble human interleukin-2 receptor produced in rodent cells. Solid-phase reconstitution of a receptor-ligand binding reaction. J Biol Chem (1987) 1.06
Human leukocyte interferon purified to homogeneity. Science (1978) 1.05
The genetics of quantitative plasma Lp(a): analysis of a large pedigree. Am J Med Genet (1983) 1.04
A study of receptors activated by analogues of prostaglandin H2 [proceedings]. Br J Pharmacol (1978) 1.04
Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. III. Resolution of two distinct roles for calcium in the cytolytic process. J Immunol (1979) 1.04
Primary and secondary structural analyses of glutathione S-transferase pi from human placenta. Arch Biochem Biophys (1990) 1.03
A dual precipitation method for quantitative plasma lipoprotein measurement without ultracentrifugation. J Lab Clin Med (1973) 1.03
The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II. Atherosclerosis (1984) 1.03
The role of calcium in the lethal hit of T lymphocyte-mediated cytolysis. Adv Exp Med Biol (1982) 1.02
Reproductive cycle of a neotropical insectivorous bat, Myotis nigricans. Nature (1970) 1.02
In vitro studies on the cell-mediated immune response to human brain tumors. I. Requirement for third-party stimulator lymphocytes in the induction of cell-mediated cytotoxic responses to allogeneic cultured gliomas. J Natl Cancer Inst (1982) 1.02
Successful hyperlipemic pregnancy. JAMA (1991) 1.02
Prostaglandin E in peptic ulcer disease. Prostaglandins (1974) 1.02
Elevated substance P and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor. Arthritis Rheum (1990) 1.02
Role of interferon-gamma in mediating the antitumor efficacy of interleukin-12. J Immunother Emphasis Tumor Immunol (1995) 1.01
Adenylate kinases in man: evidence for a third locus. Ann Hum Genet (1976) 1.00
Newcastle disease virus-induced plasma membrane damage. J Gen Virol (1974) 1.00
Sub-unit structure of soluble and mitochondrial malic enzyme: demonstration of human mitochondrial enzyme in human-mouse hybrids. Ann Hum Genet (1975) 0.98
Plasma lipoprotein retinoids after vitamin A feeding in normal man: minimal appearance of retinyl esters among low-density lipoproteins. Metabolism (1983) 0.98
Prediction of retail product weight and percentage using ultrasound and carcass measurements in beef cattle. J Anim Sci (2003) 0.97
Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC. J Immunol (1993) 0.97
Toxicity of human recombinant interleukin-2 in the mouse is mediated by interleukin-activated lymphocytes. Separation of efficacy and toxicity by selective lymphocyte subset depletion. Lab Invest (1988) 0.97