Published in Science on June 26, 1992
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J (2002) 1.88
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J Cell Biol (2003) 1.81
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles. Pflugers Arch (2004) 1.55
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J Cell Biol (2003) 1.51
The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis. J Cell Biol (2000) 1.45
Role of synaptotagmin in Ca2+-triggered exocytosis. Biochem J (2002) 1.27
Purinergic signalling and cancer. Purinergic Signal (2013) 1.18
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. EMBO J (1997) 1.03
The functional significance of synaptotagmin diversity in neuroendocrine secretion. Front Endocrinol (Lausanne) (2013) 0.96
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Biochem J (2004) 0.91
HID-1, a new component of the peptidergic signaling pathway. Genetics (2010) 0.91
Ca2+ channels as targets of neurological disease: Lambert-Eaton Syndrome and other Ca2+ channelopathies. J Bioenerg Biomembr (2003) 0.87
Unexpected Ca2+-binding properties of synaptotagmin 9. Proc Natl Acad Sci U S A (2004) 0.84
Role of synaptophysin in exocytotic release of dopamine from Xenopus oocytes injected with rat brain mRNA. Cell Mol Neurobiol (2000) 0.81
Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system. J Neuroinflammation (2016) 0.76
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob Agents Chemother (1982) 21.31
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet (1988) 8.76
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res (1999) 7.39
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene (2008) 6.82
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun (1995) 6.55
Surgical strategy for spinal metastases. Spine (Phila Pa 1976) (2001) 5.81
A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med (1991) 5.76
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ (2004) 5.49
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation (2000) 5.36
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes (2001) 5.18
Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging (1999) 4.94
Comparison of MB-Check, BACTEC, and egg-based media for recovery of mycobacteria. J Clin Microbiol (1992) 4.55
The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med (1986) 4.49
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell (1993) 4.04
Detection of Mycobacterium tuberculosis in clinical specimens by polymerase chain reaction and Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test. J Clin Microbiol (1993) 4.04
Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell (1985) 3.86
Isolation of human rotavirus in cell cultures: brief report. Arch Virol (1981) 3.83
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase. Gene (1984) 3.67
Biochemical properties of beta-lactamase produced by Flavobacterium odoratum. Antimicrob Agents Chemother (1985) 3.62
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun (1987) 3.46
An atypical variant of Fabry's disease in men with left ventricular hypertrophy. N Engl J Med (1995) 3.42
Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet (2000) 3.42
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki. N Engl J Med (1968) 3.29
Live vaccine used to prevent the spread of varicella in children in hospital. Lancet (1974) 3.24
Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature (1990) 3.23
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A (1984) 3.22
Phosphoglycerate kinase: an X-linked polymorphism in man. Am J Hum Genet (1971) 3.05
Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities. Genetics (1970) 3.05
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med (1996) 3.02
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7. DNA Res (2001) 2.99
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
Herpesviridae. Definition, provisional nomenclature, and taxonomy. The Herpesvirus Study Group, the International Committee on Taxonomy of Viruses. Intervirology (1981) 2.92
Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. J Cell Biol (1995) 2.88
Hepatic segmentectomy with caudate lobe resection for bile duct carcinoma of the hepatic hilus. World J Surg (1990) 2.86
A reaction-diffusion wave on the skin of the marine angelfish Pomacanthus. Nature (1995) 2.84
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan. Br J Cancer (2010) 2.82
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA. Virus Genes (1991) 2.77
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science (1993) 2.77
Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins. Antimicrob Agents Chemother (1980) 2.76
Risk of developing a macular hole. Arch Ophthalmol (1990) 2.71
Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev (1995) 2.61
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. J Antibiot (Tokyo) (1967) 2.60
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res (2000) 2.59
Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol (1989) 2.58
Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol (1996) 2.58
Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development (1999) 2.57
Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience. J Hepatobiliary Pancreat Surg (2000) 2.55
Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor. Science (1967) 2.55
Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains. Antimicrob Agents Chemother (1980) 2.53
Kinetic and equilibrium characterization of the Tet repressor-tetracycline complex by fluorescence measurements. Evidence for divalent metal ion requirement and energy transfer. J Mol Biol (1986) 2.52
Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant (2013) 2.51
Clonal origin of chronic myelocytic leukemia in man. Proc Natl Acad Sci U S A (1967) 2.48
ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol Cell Biol (1987) 2.48
Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis strains isolated mostly in Asian countries and their rapid detection by line probe assay. J Clin Microbiol (1999) 2.46
Fractures of the coracoid process. J Bone Joint Surg Br (1997) 2.45
Studies of novel transducing variants of lambda: dispensability of genes N and Q. Virology (1969) 2.44
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene (2006) 2.37
Genetic and molecular characteristics of X-ray-sensitive mutants of Escherichia coli defective in repair synthesis. J Bacteriol (1970) 2.37
Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. Tuber Lung Dis (1997) 2.34
Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci U S A (1985) 2.32
Submucosal endoscopic tumor resection for subepithelial tumors in the esophagus and cardia. Endoscopy (2012) 2.32
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res (1998) 2.32
Diagnosis and therapy of Kawasaki disease in children. Circulation (1993) 2.32
Glucose 6-phosphate dehydrogenase of human erythrocytes. I. Purification and characterization of normal (B+) enzyme. J Biol Chem (1966) 2.32
Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration. Br J Ophthalmol (2001) 2.30
Synthesis and antitumor activity of benzimidazolyl-1,3,5-triazine and benzimidazolylpyrimidine derivatives. Chem Pharm Bull (Tokyo) (2000) 2.30
A bacterium lipopolysaccharide that elicits Guillain-Barré syndrome has a GM1 ganglioside-like structure. J Exp Med (1993) 2.29
Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol (1989) 2.28
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Nature (1986) 2.28
Properties of a new penicillinase type produced by Bacteroides fragilis. Antimicrob Agents Chemother (1982) 2.27
Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A (1999) 2.27
Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic Acids Res (1988) 2.26
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest (1997) 2.25
Posttherapeutic intraaxial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue. AJNR Am J Neuroradiol (2000) 2.24
Requirements for the solubilization of immune aggregates by complement. The role of the classical pathway. J Clin Invest (1978) 2.24
Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinase. Biochemistry (1996) 2.24
Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle. Proc Natl Acad Sci U S A (1987) 2.22
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature (1997) 2.20
A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. J Cell Biol (1994) 2.20
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet (1997) 2.20
Subcellular location of superoxide dismutase in spinach leaves and preparation and properties of crystalline spinach superoxide dismutase. Eur J Biochem (1973) 2.19
A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution. Genetics (2000) 2.19
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem (2001) 2.19
Solubilization of antigen-antibody complexes: a new function of complement as a regulator of immune reactions. Prog Allergy (1980) 2.19
Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro. J Clin Invest (1984) 2.17
Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation. AJR Am J Roentgenol (1995) 2.13