Published in Immunol Rev on June 01, 1992
The central role of CD4(+) T cells in the antitumor immune response. J Exp Med (1998) 6.02
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med (1997) 5.56
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med (1996) 4.54
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 3.98
Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med (1994) 2.90
Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity. Clin Microbiol Rev (2008) 2.36
Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol (2010) 2.29
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol (2010) 2.20
A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun (1995) 1.99
Protective immunity to nematode infection is induced by CTLA-4 blockade. J Exp Med (1997) 1.72
Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J Exp Med (1996) 1.67
Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A (2009) 1.63
Interleukin-12 in infectious diseases. Clin Microbiol Rev (1997) 1.63
T-cell-dependent control of acute Giardia lamblia infections in mice. Infect Immun (2000) 1.48
Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection. Infect Immun (1993) 1.46
Helminths and harmony. Gut (2004) 1.41
Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc Natl Acad Sci U S A (2004) 1.36
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J Exp Med (2013) 1.26
In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin. Infect Immun (1995) 1.24
Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J Exp Med (1995) 1.23
Ivermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection. Clin Exp Immunol (1994) 1.19
Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. J Immunol (2011) 1.16
Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J Exp Med (1994) 1.10
Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris. Infect Immun (1996) 1.10
Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites. Genome Biol (2004) 1.10
IL-33-dependent induction of allergic lung inflammation by FcγRIII signaling. J Clin Invest (2013) 1.08
Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite. Infect Immun (2000) 1.03
Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infect Immun (1998) 1.01
Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol (2012) 1.00
A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol (2014) 0.99
Immune responses to Trichinella spiralis and T. pseudospiralis in mice. Immunology (1994) 0.98
Interleukin-5 is the predominant cytokine produced by peripheral blood mononuclear cells in alveolar echinococcosis. Infect Immun (1995) 0.96
The costs of dominance: testosterone, cortisol and intestinal parasites in wild male chimpanzees. Biopsychosoc Med (2010) 0.96
Anti-interleukin-4 modulation of the Th2 polarized response to the parasitic nematode Brugia pahangi. Infect Immun (1996) 0.94
The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunol (2015) 0.91
Differing antibody IgG isotypes in the polar forms of leprosy and cutaneous leishmaniasis characterized by antigen-specific T cell anergy. Clin Exp Immunol (1995) 0.90
A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps. Infect Immun (2004) 0.88
Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses. PLoS Pathog (2014) 0.88
Progression of visceral leishmaniasis due to Leishmania infantum in BALB/c mice is markedly slowed by prior infection with Trichinella spiralis. Infect Immun (1997) 0.86
Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A (2005) 0.85
Is human immunodeficiency virus infection a risk factor for Strongyloides stercoralis hyperinfection and dissemination. PLoS Negl Trop Dis (2012) 0.84
Specific T-cell tolerance may reflect selective activation of lymphokine synthesis. Proc Natl Acad Sci U S A (1995) 0.84
MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. J Immunol (2014) 0.84
Modulation of dendritic cell function and immune response by cysteine protease inhibitor from murine nematode parasite Heligmosomoides polygyrus. Immunology (2013) 0.84
Intra-phylum and inter-phyla associations among gastrointestinal parasites in two wild mammal species. Parasitol Res (2013) 0.83
The role of parasite-induced immunodepression, rank and social environment in the modulation of behaviour and hormone concentration in male laboratory mice (Mus musculus). Proc Biol Sci (1998) 0.83
Anisakidae in Fishing Products Sold in Sicily. Ital J Food Saf (2014) 0.83
Small ruminant resistance against gastrointestinal nematodes: a case of Haemonchus contortus. Parasitol Res (2011) 0.82
Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages. Infect Immun (1996) 0.82
A major allergen of lymphatic filarial nematodes is a parasite homolog of the gamma-glutamyl transpeptidase. Mol Med (1996) 0.81
The immunosuppressive activity of Ascaris suum is due to high molecular weight components. Clin Exp Immunol (1998) 0.80
L3L4ES antigen and secretagogues induce histamine release from porcine peripheral blood basophils after Ascaris suum infection. Parasitol Res (2006) 0.79
An in vitro model to evaluate the cytokine response in Echinococcus infections. Parasitol Res (2004) 0.78
Mina: a Th2 response regulator meets TGFβ. Curr Opin Immunol (2014) 0.76
Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol (2015) 0.75
Functional impairment of murine dendritic cell subsets following infection with infective larval stage 3 of Brugia malayi. Infect Immun (2016) 0.75
The role of cytokines in inflammatory bowel disease. Mediators Inflamm (1994) 0.75
Construction and identification of the recombinant plasmid pET30a-EgA31-Eg95 of Echinococcus granulosus. Exp Ther Med (2013) 0.75
Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN mice. Parasitol Res (2007) 0.75
Interleukin-12 modulates T-cell responses to microfilariae but fails to abrogate interleukin-5-dependent immunity in a mouse model of onchocerciasis. Immunology (1999) 0.75
Strongyloides stercoralis infection in a patient with sickle cell disease. Ann Trop Med Parasitol (2011) 0.75
Avidity Studies in Anisakis simplex-Associated Allergic Diseases. J Allergy (Cairo) (2013) 0.75
Modulation of cellular immune response by cytokines in bancroftian filariasis. Indian J Clin Biochem (1997) 0.75
The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice. Parasitol Res (2016) 0.75
Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens. Med Microbiol Immunol (2014) 0.75
Cytokine signature and antibody-mediated response against fresh and attenuated Anisakis simplex (L3) administration into Wistar rats: implication for anti-allergic reaction. Parasitol Res (2015) 0.75
Syphacia obvelata: A New Hope to Induction of Intestinal Immunological Tolerance in C57BL/6 Mice. Korean J Parasitol (2017) 0.75
Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol (1988) 5.12
The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev (1988) 5.02
Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69
IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity (1998) 4.65
Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu Rev Immunol (1997) 4.22
IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol (1992) 4.02
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun (1998) 3.80
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol (1991) 3.65
Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med (1993) 3.38
Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). I. Characterization of B-lymphocyte-, T-lymphocyte-, and monocyte-enriched fractions by flow cytometric analysis. Cell Immunol (1984) 3.36
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J Immunol (1993) 3.34
Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J Immunol (1993) 3.29
Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J Immunol (1991) 3.04
Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A (1991) 3.01
Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med (1994) 2.90
Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med (1988) 2.84
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med (1995) 2.52
IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med (1997) 2.48
Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens. J Exp Med (1992) 2.47
Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A (1991) 2.41
Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol (2001) 2.26
Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin. J Immunol (1981) 2.26
Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol (1994) 2.25
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22
Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci U S A (1990) 2.18
Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice. J Exp Med (1991) 2.16
IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. J Immunol (1997) 2.09
Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol (1996) 2.06
Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A (2008) 2.06
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res (1998) 2.04
IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J Immunol (1990) 2.03
IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins. J Immunol (1981) 1.97
Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG. J Immunol (1982) 1.96
Circulating and mitogen-induced immunoglobulin-secreting cells in human peripheral blood: evaluation by a modified reverse hemolytic plaque assay. J Immunol (1978) 1.93
Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol (1994) 1.92
IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma. Proc Natl Acad Sci U S A (1989) 1.89
Three-dimensional structure of recombinant human interferon-gamma. Science (1991) 1.88
Cryptosporidium infection in an adult mouse model. Independent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity. J Immunol (1991) 1.87
Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J Immunol (1988) 1.84
Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response. J Immunol (1987) 1.82
Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect. J Exp Med (1975) 1.82
Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J Immunol (1991) 1.82
Regulation of IgG1 and IgE production by interleukin 4. Immunol Rev (1988) 1.80
bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med (1996) 1.79
Intestinal nematode parasites, cytokines and effector mechanisms. Int J Parasitol (1998) 1.75
Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus. Clin Exp Immunol (1979) 1.74
New mouse models for chronic Cryptosporidium infection in immunodeficient hosts. Infect Immun (1990) 1.71
Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infect Immun (1994) 1.67
IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide. J Immunol (1988) 1.66
Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells. J Immunol (1986) 1.66
The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J Immunol (1988) 1.64
Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest (1989) 1.62
A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J Immunol (1993) 1.62
Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody. J Immunol (1985) 1.60
In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL. J Immunol (2001) 1.59
Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE. J Immunol (1983) 1.58
Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells. Int Immunol (1993) 1.58
The role of IL-4 in Heligmosomoides polygyrus-induced alterations in murine intestinal epithelial cell function. J Immunol (2001) 1.56
Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Arthritis Rheum (1997) 1.55
Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism. J Immunol (2000) 1.52
Mouse immunoglobulin D: construction and characterization of a cloned delta chain cDNA. Proc Natl Acad Sci U S A (1980) 1.50
Production of BSF-1 during an in vivo, T-dependent immune response. J Immunol (1986) 1.47
B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol (1997) 1.46
Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J Immunol (1995) 1.46
Effect of anti-interferon-gamma and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J Neuroimmunol (1992) 1.45
Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium. J Exp Med (1987) 1.43
Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med (1990) 1.43
IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice. J Immunol (1995) 1.43
Polyneuropathy in juvenile dermatomyositis. J Rheumatol (1995) 1.42
Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am J Physiol (1997) 1.42
Control of human B lymphocyte responsiveness: enhanced suppressor T cell activity after in vitro incubation. J Immunol (1978) 1.41
Preparation and characterization of monoclonal antibodies to the trichothecene mycotoxin T-2. Appl Environ Microbiol (1985) 1.41