Published in J Exp Med on July 21, 1997
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med (2000) 16.09
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog (2009) 2.57
Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev (2004) 1.95
Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection. Eur J Immunol (2007) 1.75
Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. PLoS Pathog (2010) 1.53
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med (1998) 1.32
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc Natl Acad Sci U S A (2000) 1.31
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A (2010) 1.27
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity. J Virol (2006) 1.25
CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infect Immun (1999) 1.23
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help. J Exp Med (1999) 1.18
Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. J Exp Med (2001) 1.17
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathog (2012) 1.14
Helminthic therapy: improving mucosal barrier function. Trends Parasitol (2012) 1.06
Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. Clin Exp Immunol (1999) 1.04
Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. Clin Exp Immunol (2001) 1.00
The landscape of human genes involved in the immune response to parasitic worms. BMC Evol Biol (2010) 0.99
Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. Diabetes Care (2008) 0.95
Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. Immunology (1999) 0.95
Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody. Infect Immun (1999) 0.89
CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response. Infect Immun (2000) 0.89
T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens. Immunology (2004) 0.84
B7 costimulatory ligand regulates development of the T-cell response to Cryptococcus neoformans. Immunology (1999) 0.83
Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease. Am J Pathol (1998) 0.82
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge. Immunology (2008) 0.81
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine (2015) 0.77
A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis. Genet Test Mol Biomarkers (2012) 0.75
Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function. PLoS Pathog (2016) 0.75
Increased CTLA-4(+) T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary disease. Immunology (2017) 0.75
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
The Yin and Yang of T cell costimulation. Science (1995) 15.19
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity (1995) 14.90
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med (1995) 8.31
Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (1993) 6.54
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med (1996) 6.13
CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med (1996) 4.97
Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science (1989) 4.57
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med (1992) 3.77
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol (1995) 3.06
The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev (1992) 2.69
Parasitological review. Nippostrongylus brasiliensis: a review of immunity and host-parasite relationship in the rat. Exp Parasitol (1971) 2.42
Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J Immunol (1991) 1.82
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol (1996) 1.69
The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J Immunol (1988) 1.64
IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. J Immunol (1993) 1.36
Staphylococcal-derived superantigen enhances peanut induced Th2 responses in the skin. Clin Exp Allergy (2011) 0.85
Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro. Immunol Cell Biol (1999) 0.84
Th2-dependent airway eosinophilia is regulated by preproenkephalin. J Neuroimmunol (2000) 0.76
Application of enzymeimmunoassay to measure oestrone sulphate concentrations in cow's milk during pregnancy. J Steroid Biochem Mol Biol (1994) 0.75
Evaluation of antibody- and antigen-coated enzymeimmunoassays for measuring oestrone-3-glucuronide concentrations in urine. Clin Chim Acta (1995) 0.75
Problems of ethnic groups in our community. Aust J Physiother (2014) 0.75
Generation of monoclonal antibody to ovine FSH and its application in immunoneutralization and enzymeimmunoassay. J Reprod Fertil Suppl (1995) 0.75