PubRank

S Ghisla

Author PubWeight™ 98.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Fluorescence and optical characteristics of reduced flavines and flavoproteins. Biochemistry 1974 2.37
2 The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site. EMBO J 2000 1.67
3 A hydrophobic sequence motif common to N-hydroxylating enzymes. Trends Biochem Sci 1998 1.57
4 The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation. Proc Natl Acad Sci U S A 2000 1.41
5 Effects of two mutations detected in medium chain acyl-CoA dehydrogenase (MCAD)-deficient patients on folding, oligomer assembly, and stability of MCAD enzyme. J Biol Chem 1995 1.21
6 New flavins for old: artificial flavins as active site probes of flavoproteins. Biochem J 1986 1.20
7 Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence. J Biol Chem 1993 1.18
8 Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair. J Biol Chem 2001 1.17
9 Identification and properties of new flavins in electron-transferring flavoprotein from Peptostreptococcus elsdenii and pig-liver glycolate oxidase. Eur J Biochem 1974 1.10
10 7-Substituted pterins: formation during phenylalanine hydroxylation in the absence of dehydratase. Biochem Biophys Res Commun 1990 1.09
11 On the mechanism of D-amino acid oxidase. Structure/linear free energy correlations and deuterium kinetic isotope effects using substituted phenylglycines. J Biol Chem 1997 1.09
12 Inactivation of general acyl-CoA dehydrogenase from pig kidney by a metabolite of hypoglycin A. J Biol Chem 1981 1.08
13 Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity. Biochemistry 1996 1.07
14 Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase: evidence for the transfer of the beta-hydrogen to the flavin N(5)-position as a hydride. Biochemistry 1984 1.07
15 Kinetic mechanisms of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum. Eur J Biochem 1999 1.05
16 Two similar gene clusters coding for enzymes of a new type of aerobic 2-aminobenzoate (anthranilate) metabolism in the bacterium Azoarcus evansii. J Bacteriol 2001 1.05
17 2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction. Eur J Biochem 1989 1.04
18 Oxidation-reduction of general acyl-CoA dehydrogenase by the butyryl-CoA/crotonyl-CoA couple. A new investigation of the rapid reaction kinetics. Biochemistry 1988 1.03
19 Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation. Biochim Biophys Acta 1993 1.02
20 2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products. Eur J Biochem 1990 1.02
21 Cholesterol oxidase from Brevibacterium sterolicum. The relationship between covalent flavinylation and redox properties. J Biol Chem 2001 1.01
22 On the structure of flavin-oxygen intermediates involved in enzymatic reactions. Eur J Biochem 1977 1.01
23 NIH shift in flavin-dependent monooxygenation: mechanistic studies with 2-aminobenzoyl-CoA monooxygenase/reductase. Proc Natl Acad Sci U S A 1999 1.00
24 Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved. Eur J Biochem 1985 0.99
25 Biosynthesis of riboflavin. 6,7-Dimethyl-8-ribityllumazine 5'-phosphate is not a substrate for riboflavin synthase. Biochim Biophys Acta 1978 0.98
26 Covalent adducts of lactate oxidase. Photochemical formation and structure identification. J Biol Chem 1979 0.97
27 Kinetic mechanism of D-amino acid oxidases from Rhodotorula gracilis and Trigonopsis variabilis. J Biol Chem 1993 0.97
28 Mechanism of activation of acyl-CoA substrates by medium chain acyl-CoA dehydrogenase: interaction of the thioester carbonyl with the flavin adenine dinucleotide ribityl side chain. Biochemistry 1999 0.96
29 2-Aminobenzoyl-CoA monooxygenase/reductase. Evidence for two distinct loci catalyzing substrate monooxygenation and hydrogenation. Eur J Biochem 1995 0.95
30 On the reaction mechanism of L-lactate oxidase: quantitative structure-activity analysis of the reaction with para-substituted L-mandelates. Proc Natl Acad Sci U S A 1997 0.95
31 pH and kinetic isotope effects in d-amino acid oxidase catalysis. Eur J Biochem 2001 0.94
32 Fluorescence and optical characteristics of reduced flavins and flavoproteins. Methods Enzymol 1980 0.94
33 Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate. Biochemistry 1976 0.93
34 Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli. J Biol Chem 1990 0.93
35 7-substituted pterins in humans with suspected pterin-4a-carbinolamine dehydratase deficiency. Mechanism of formation via non-enzymatic transformation from 6-substituted pterins. Eur J Biochem 1992 0.92
36 Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase. Biochemistry 1996 0.92
37 The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate. Biochemistry 1976 0.92
38 Purification of the yellow fluorescent protein from Vibrio fischeri and identity of the flavin chromophore. Biochem Biophys Res Commun 1987 0.92
39 Studies on succinate dehydrogenase. 8 -Histidyl-FAD as the active center of succinate dehydrogenase. Eur J Biochem 1972 0.91
40 Location of the active site and proposed catalytic mechanism of pterin-4a-carbinolamine dehydratase. Eur J Biochem 1996 0.91
41 Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase. Eur J Biochem 1992 0.90
42 Mechanism of elementary catalytic steps of pyruvate oxidase from Lactobacillus plantarum. Biochemistry 2000 0.90
43 Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver. Eur J Biochem 1986 0.90
44 Stereochemistry and accessibility of prosthetic groups in flavoproteins. Biochemistry 1988 0.89
45 Human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1 alpha. Characterization and kinetic analysis of wild-type and mutant enzymes. Eur J Biochem 1995 0.89
46 Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation. Eur J Biochem 1997 0.89
47 Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum. Eur J Biochem 1997 0.89
48 Studies with lysine N6-hydroxylase. Effect of a mutation in the assumed FAD binding site on coenzyme affinities and on lysine hydroxylating activity. Biol Chem 1999 0.88
49 L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme. Eur J Biochem 2001 0.88
50 Properties of flavins where the 8-methyl group is replaced by mercapto- residues. J Biol Chem 1979 0.88
51 Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site. Biochem J 1999 0.88
52 Mechanism of inactivation of the flavoenzyme lactate oxidase by oxalate. J Biol Chem 1975 0.87
53 Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase. J Biol Chem 1998 0.87
54 Characterization of D-amino acid oxidase from Trigonopsis variabilis. Biochem Mol Biol Int 1993 0.86
55 Activation of thiamin diphosphate and FAD in the phosphatedependent pyruvate oxidase from Lactobacillus plantarum. J Biol Chem 1998 0.86
56 Biochemical characterization of purified, human recombinant Lys304-->Glu medium-chain acyl-CoA dehydrogenase containing the common disease-causing mutation and comparison with the normal enzyme. Eur J Biochem 1997 0.85
57 Studies with flavin analogs provide evidence that a protonated reduced FMN is the substrate-induced transient intermediate in the reaction of Escherichia coli chorismate synthase. J Biol Chem 1996 0.85
58 8-Mercaptoflavins as active site probes of flavoenzymes. J Biol Chem 1979 0.85
59 Studies on the catalytic mechanism of lactate oxidase. Formation of enantiomeric flavin-N(5)-glycollyl adducts via carbanion intermediates. J Biol Chem 1980 0.85
60 Characterization and postulated structure of the primary emitter in the bacterial luciferase reaction. Proc Natl Acad Sci U S A 1984 0.84
61 Chemical synthesis and some properties of 6-substituted flavins. Biochemistry 1980 0.84
62 Medium-chain acyl coenzyme A dehydrogenase from pig kidney has intrinsic enoyl coenzyme A hydratase activity. Biochemistry 1986 0.84
63 Molecular complex of lumiflavin and 2-aminobenzoic acid: crystal structure, crystal spectra, and solution properties. Biochemistry 1981 0.84
64 Studies on the reaction mechanism of general acyl-CoA dehydrogenase. Determination of selective isotope effects in the dehydrogenation of butyryl-CoA. Eur J Biochem 1986 0.84
65 Substrate activation by acyl-CoA dehydrogenases: transition-state stabilization and pKs of involved functional groups. Biochemistry 1998 0.83
66 Mechanism of bacterial bioluminescence: 4a,5-dihydroflavin analogs as models for luciferase hydroperoxide intermediates and the effect of substituents at the 8-position of flavin on luciferase kinetics. Biochemistry 1993 0.83
67 Kinetic and mechanistic studies on the reactions of 2-aminobenzoyl-CoA monooxygenase/reductase. Eur J Biochem 1995 0.83
68 Studies on the reaction mechanism of lactate oxidase. Formation of two covalent flavin-substrate adducts on reaction with glycollate. J Biol Chem 1980 0.82
69 Studies on the mechanism of action of the flavoenzyme lactate oxidase. Proton uptake and release during the binding of transition state analogs. J Biol Chem 1977 0.82
70 Cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum: effect of surfactants and organic solvents on activity. Biotechnol Appl Biochem 1999 0.81
71 Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Eur J Biochem 2001 0.81
72 A time-dependent bacterial bioluminescence emission spectrum in an in vitro single turnover system: energy transfer alone cannot account for the yellow emission of Vibrio fischeri Y-1. Proc Natl Acad Sci U S A 1990 0.81
73 Metabolic consequences of methylenecyclopropylglycine poisoning in rats. Biochem J 1991 0.81
74 NMR.-Study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ("reduced flavin"). Studies in the flavin series, XIX. Helv Chim Acta 1973 0.81
75 Protonic equilibria in the reductive half-reaction of the medium-chain acyl-CoA dehydrogenase. Biochemistry 1998 0.80
76 Characterization of wild-type human medium-chain acyl-CoA dehydrogenase (MCAD) and mutant enzymes present in MCAD-deficient patients by two-dimensional gel electrophoresis: evidence for post-translational modification of the enzyme. Biochem Med Metab Biol 1994 0.80
77 Flavin-dependent alcohol oxidase from yeast. Studies on the catalytic mechanism and inactivation during turnover. Eur J Biochem 1986 0.80
78 Flavoenzyme structure and function. Approaches using flavin analogues. Methods Mol Biol 1999 0.80
79 Suspected pterin-4a-carbinolamine dehydratase deficiency: hyperphenylalaninaemia due to inhibition of phenylalanine hydroxylase by tetrahydro-7-biopterin. J Inherit Metab Dis 1992 0.80
80 Model studies on flavin-dependent carbonyl-activation: reduction of carbonyl compounds by flavohydroquinone. Z Naturforsch B 1972 0.80
81 Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides. J Biol Chem 1983 0.79
82 Structure and catalytic inactivity of the bacterial luciferase neutral flavin radical. Eur J Biochem 1982 0.79
83 Fluorescence properties of reduced flavins and flavoproteins. Eur J Biochem 1979 0.79
84 Mechanism of hypoglycaemic action of methylenecyclopropylglycine. Biochem J 1989 0.79
85 Studies with general acyl-CoA dehydrogenase from pig kidney. Inactivation by a novel type of "suicide" inhibitor, 3,4-pentadienoyl-CoA. Eur J Biochem 1985 0.79
86 Molecular evolution and substrate specificity of acyl-CoA dehydrogenases: chimaeric "medium/long' chain-specific enzyme from medium-chain acyl-CoA dehydrogenase. Biochem Soc Trans 1996 0.79
87 Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain acyl-CoA dehydrogenase deficiency. J Inherit Metab Dis 1991 0.78
88 Studies on the active centre of Rhodotorula gracilis D-amino acid oxidase and comparison with pig kidney enzyme. Biochem J 1992 0.78
89 Studies on succinate dehydrogenase. Site of attachment of the covalently-bound flavin to the peptide chain. Eur J Biochem 1972 0.78
90 8-Azidoflavins as photoaffinity labels for flavoproteins. J Biol Chem 1985 0.78
91 Activation of thiamin diphosphate in enzymes. Biochim Biophys Acta 1998 0.78
92 Structure of the flavin adduct formed in the suicide reaction of alpha-hydroxybutynoate with D-lactate dehydrogenase. Biochemistry 1979 0.78
93 Spectroscopic characterization of human liver pterin 4a-carbinolamine dehydratase. Adv Exp Med Biol 1993 0.78
94 New aspects in biopterin biosynthesis in man. FEBS Lett 1981 0.78
95 Biosynthesis of tetrahydrobiopterin in man. J Inherit Metab Dis 1985 0.78
96 Identification and properties of 8-hydroxyflavin--adenine dinucleotide in electron-transferring flavoprotein from Peptostreptococcus elsdenii. Eur J Biochem 1976 0.77
97 Redox properties of human medium-chain acyl-CoA dehydrogenase, modulation by charged active-site amino acid residues. Biochemistry 1998 0.77
98 Spectral detection of an intermediate preceding the excited state in the bacterial luciferase reaction. Biochemistry 1993 0.77
99 Medium-chain acyl CoA dehydrogenase: evidence for phosphorylation. Biol Chem 1997 0.77
100 Bioluminescence emission from the reaction of luciferase-flavin mononucleotide radical with O2-.. Biochemistry 1983 0.77
101 Pterin-4a-carbinolamine dehydratase from Pseudomonas aeruginosa: characterization, catalytic mechanism and comparison to the human enzyme. Biol Chem 1998 0.77
102 6-Azido- and 6-aminoflavins as active-site probes of flavin enzymes. Biochemistry 1986 0.77
103 Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver. Biochem Biophys Res Commun 1986 0.77
104 Preparation and some properties of 6-substituted flavins as active site probes for flavin enzymes. Biochemistry 1986 0.77
105 FAD analogues as prosthetic groups of human glutathione reductase. Properties of the modified enzyme species and comparisons with the active site structure. Eur J Biochem 1985 0.76
106 4-Thioflavins as active site probes of flavoproteins. Reactions with sulfite. J Biol Chem 1984 0.76
107 4-Thioflavins as active site probes of flavoproteins. General properties. J Biol Chem 1984 0.76
108 Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate. Biochemistry 1979 0.76
109 Characterization of medium-chain acyl-CoA dehydrogenase (MCAD) with a point mutation associated with MCAD deficiency. Prog Clin Biol Res 1992 0.75
110 Structurally different rat liver medium-chain acyl CoA dehydrogenases directed by complementary DNAs differing in their 5'-region. Biochim Biophys Acta 1991 0.75
111 Structure of a novel flavin chromophore from Avena coleoptiles, the possible 'blue light' photoreceptor. Eur J Biochem 1984 0.75
112 Progress in the study of biosynthesis and role of 7-substituted pterins: function of pterin-4a-carbinolamine dehydratase. Adv Exp Med Biol 1993 0.75
113 Biosynthesis of tetrahydrobiopterin: possible involvement of tetrahydropterin intermediates. Neurochem Int 1984 0.75
114 Studies in the flavin series. XVII. J Chem Soc Perkin 1 1972 0.75
115 In vitro synthesis of pig kidney general acyl CoA dehydrogenase. Biochem Biophys Res Commun 1986 0.75
116 6-Thiocyanatoflavins and 6-mercaptoflavins as active-site probes of flavoproteins. Biochemistry 1986 0.75
117 Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii. J Biol Chem 1973 0.75
118 The synthesis of succinate-dehydrogenase riboflavin. Angew Chem Int Ed Engl 1970 0.75
119 7-substituted pterins: formation and occurrence. J Nutr Sci Vitaminol (Tokyo) 1992 0.75
120 Structural, spectroscopic and catalytic activity studies on glutathione reductase reconstituted with FAD analogues. Eur J Biochem 1991 0.75
121 Molecular cloning of cDNA for rat liver general acyl CoA dehydrogenase and homology between the rat liver and pig kidney enzymes. Biochem Int 1987 0.75
122 Prostaglandin 9-ketoreductase from pig and human kidney: purification, properties and identity with human carbonyl reductase. Eicosanoids 1992 0.75
123 Bioluminescence emission of bacterial luciferase with 1-deaza-FMN. Evidence for the noninvolvement of N(1)-protonated flavin species as emitters. Eur J Biochem 1989 0.75
124 Isolation, synthesis, and properties of 8-hydroxyflavins. Methods Enzymol 1980 0.75
125 Identification and role of ionizing functional groups at the active center of Rhodotorula gracilis D-amino acid oxidase. FEBS Lett 2001 0.75