Published in Experientia on January 15, 1992
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain (2008) 5.89
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A (1995) 3.36
Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans. Brain Pathol (2011) 2.11
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. Proc Natl Acad Sci U S A (2000) 1.88
PICALM modulates autophagy activity and tau accumulation. Nat Commun (2014) 1.60
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathol (1992) 1.38
The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation. Curr Opin Neurol (2008) 1.11
Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease. Neuroimage (2009) 1.07
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol (1996) 0.99
Multidimensional methods for the formulation of biopharmaceuticals and vaccines. J Pharm Sci (2011) 0.98
Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease. Neuroimage (2010) 0.97
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice. Neuroscience (2008) 0.96
Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl) (2005) 0.96
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. J Neurosci (2013) 0.95
Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease. Neuropsychopharmacology (2008) 0.93
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest (1996) 0.92
Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions. J Pharmacol Exp Ther (2009) 0.88
Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease. PLoS One (2014) 0.86
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Antiviral Res (2012) 0.86
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther (2012) 0.86
Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging (2011) 0.86
Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model. Am J Pathol (2013) 0.84
Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease. Brain Res (2009) 0.84
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology. Am J Pathol (2010) 0.83
Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis. Dis Model Mech (2010) 0.80
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. Am J Pathol (2009) 0.79
Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. J Alzheimers Dis (2015) 0.79
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun (2015) 0.77
Statin Therapy and the Development of Cerebral Amyloid Angiopathy-A Rodent in Vivo Approach. Int J Mol Sci (2016) 0.76
The use of recently developed histochemical markers for localizing neurotoxicant induced regional brain pathologies. Toxins (Basel) (2014) 0.75
Simple model systems: a challenge for Alzheimer's disease. Immun Ageing (2012) 0.75
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev (2000) 5.40
Life and death of neurons in the aging brain. Science (1997) 4.52
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology (2003) 3.62
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience (2005) 3.41
New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales. Neuroscience (2005) 3.06
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience (2004) 3.06
Design-based stereology in neuroscience. Neuroscience (2005) 2.90
A neuronal morphologic type unique to humans and great apes. Proc Natl Acad Sci U S A (1999) 2.81
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (1995) 2.79
Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol (1995) 2.71
Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neurosci Lett (1989) 2.69
Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci (1998) 2.54
Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat (2000) 1.82
Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry (2000) 1.81
Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb Cortex (1994) 1.73
Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol (1995) 1.69
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery. Neuroscience (2009) 1.68
Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study. Neurology (1999) 1.61
Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways. Vision Res (1997) 1.59
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol (1992) 1.49
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab (1996) 1.48
Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol (2001) 1.48
Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma. Aust N Z J Ophthalmol (1997) 1.47
Balint's syndrome in Alzheimer's disease: specific disruption of the occipito-parietal visual pathway. Brain Res (1989) 1.43
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathol (1992) 1.38
Selective disconnection of specific visual association pathways in cases of Alzheimer's disease presenting with Balint's syndrome. J Neuropathol Exp Neurol (1990) 1.36
Visual cortical projections and chemoarchitecture of macaque monkey pulvinar. J Comp Neurol (2000) 1.32
Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia. Neurology (2007) 1.31
Spindle neurons of the human anterior cingulate cortex. J Comp Neurol (1995) 1.27
Does Alzheimer's disease begin in the brainstem? Neuropathol Appl Neurobiol (2009) 1.26
Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol (1994) 1.26
Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience (2003) 1.22
Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Arch Neurol (1995) 1.22
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res (1996) 1.20
Specific pathological Tau protein variants characterize Pick's disease. J Neuropathol Exp Neurol (1996) 1.18
Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: a quantitative analysis of six cases. Acta Neuropathol (1992) 1.18
Clinical validity of Braak neuropathological staging in the oldest-old. Acta Neuropathol (2000) 1.17
Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice. J Comp Neurol (2000) 1.17
Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol (1994) 1.16
Neuropathological observations in a case of autism presenting with self-injury behavior. Acta Neuropathol (1991) 1.16
Vascular dementia. A clinicopathological study. J Neurol Sci (1990) 1.15
Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol (1998) 1.14
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts. Brain Res Brain Res Rev (1997) 1.14
Synaptic distribution of the AMPA-GluR2 subunit and its colocalization with calcium-binding proteins in rat cerebral cortex: an immunohistochemical study using a GluR2-specific monoclonal antibody. Exp Neurol (1996) 1.14
Quantitative analysis of the dendritic morphology of corticocortical projection neurons in the macaque monkey association cortex. Neuroscience (2002) 1.14
Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol Aging (1997) 1.10
Brain microvascular changes in Alzheimer's disease and other dementias. Ann N Y Acad Sci (1997) 1.09
Cortical dopaminergic innervation among humans, chimpanzees, and macaque monkeys: a comparative study. Neuroscience (2008) 1.09
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology (2013) 1.08
Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience (2002) 1.08
Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathol Appl Neurobiol (2011) 1.07
A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease. Eur Neurol (1997) 1.07
A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease. Brain Res (1987) 1.06
Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging. Neuroscience (2011) 1.06
Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation. Exp Neurol (2000) 1.04
Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease. Acta Neuropathol (1996) 1.04
Dendritic spine changes associated with normal aging. Neuroscience (2012) 1.03
Distribution of parvalbumin immunoreactivity in the visual cortex of Old World monkeys and humans. J Comp Neurol (1990) 1.02
Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Exp Neurol (1998) 1.01
Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells. J Biol Chem (1997) 1.01
Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. Hum Gene Ther (2000) 1.01
Neurochemical, morphologic, and laminar characterization of cortical projection neurons in the cingulate motor areas of the macaque monkey. J Comp Neurol (1996) 1.00
Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Arch Neurol (1995) 1.00
Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population. Acta Neuropathol (1994) 1.00
Distinct patterns of neuronal loss and Alzheimer's disease lesion distribution in elderly individuals older than 90 years. J Neuropathol Exp Neurol (1996) 1.00
Cytology of human caudomedial cingulate, retrosplenial, and caudal parahippocampal cortices. J Comp Neurol (2001) 1.00
Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett (1993) 0.99
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience (2006) 0.98
The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease. Neuropathol Appl Neurobiol (2013) 0.98
Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys. Exp Neurol (1999) 0.97
An anatomic substrate for visual disconnection in Alzheimer's disease. Ann N Y Acad Sci (1991) 0.97
Immunohistochemical identification of thrombospondin in normal human brain and in Alzheimer's disease. Am J Pathol (1992) 0.97
Immediate causes of death of demented and non-demented elderly. Acta Neurol Scand Suppl (2000) 0.96
Neuropathological analysis of an asymptomatic adult case with Dandy-Walker variant. Neuropathol Appl Neurobiol (2006) 0.95
Alzheimer's disease with asymmetric atrophy of the cerebral hemispheres: morphometric analysis of four cases. Acta Neuropathol (1994) 0.95
Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report. Acta Neuropathol (1993) 0.95
Selective vulnerability of neocortical association areas in Alzheimer's disease. Microsc Res Tech (1998) 0.94
Sensitivity and specificity of newly proposed clinical criteria for possible vascular dementia. Neurology (1997) 0.94
Adenosine stimulates glycogenolysis in mouse cerebral cortex: a possible coupling mechanism between neuronal activity and energy metabolism. J Neurosci (1986) 0.94