Published in Nat Med on September 01, 2000
Sleep state switching. Neuron (2010) 4.94
History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest (2010) 3.17
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A (2005) 3.05
Circadian rhythms, sleep, and metabolism. J Clin Invest (2011) 2.60
Afferents to the orexin neurons of the rat brain. J Comp Neurol (2006) 2.57
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol (2007) 2.34
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology (2005) 2.33
Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A (2001) 2.20
Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A (2009) 2.20
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci (2003) 1.88
The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci (2009) 1.82
Unearthing the phylogenetic roots of sleep. Curr Biol (2008) 1.71
CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiatry (2003) 1.69
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet (2010) 1.67
Common variants in P2RY11 are associated with narcolepsy. Nat Genet (2010) 1.65
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep (2010) 1.64
Neuromodulation of brain states. Neuron (2012) 1.64
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A (2004) 1.61
Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci (2011) 1.58
Response variability in Attention-Deficit/Hyperactivity Disorder: a neuronal and glial energetics hypothesis. Behav Brain Funct (2006) 1.57
A consensus definition of cataplexy in mouse models of narcolepsy. Sleep (2009) 1.55
REM sleep: a biological and psychological paradox. Sleep Med Rev (2011) 1.55
Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat Commun (2013) 1.55
Loss of hypocretin (orexin) neurons with traumatic brain injury. Ann Neurol (2009) 1.54
Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol (2011) 1.53
Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep (2009) 1.52
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet (2012) 1.48
Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep (2010) 1.47
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A (2009) 1.44
The hypocretins/orexins: integrators of multiple physiological functions. Br J Pharmacol (2014) 1.42
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Proc Natl Acad Sci U S A (2016) 1.42
Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci (2007) 1.40
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. PLoS One (2016) 1.38
Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol (2001) 1.38
The hypocretins as sensors for metabolism and arousal. J Physiol (2008) 1.35
Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain (2011) 1.35
Genetic contributions to behavioural diversity at the gene-environment interface. Nat Rev Genet (2011) 1.32
Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. Sleep (2010) 1.30
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A (2004) 1.29
Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area. J Physiol (2002) 1.29
Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J Physiol (2002) 1.28
GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats. J Physiol (2004) 1.28
Narcolepsy: immunological aspects. Sleep Med Rev (2008) 1.28
Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep (2007) 1.26
Clinical and neurobiological aspects of narcolepsy. Sleep Med (2007) 1.26
The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Res (2009) 1.25
Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis. Neurology (2004) 1.24
Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacology (Berl) (2005) 1.23
Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins. J Comp Neurol (2006) 1.23
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci (2011) 1.23
The diurnal rhythm of hypocretin in young and old F344 rats. Sleep (2004) 1.22
Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biol Psychiatry (2010) 1.21
Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep (2010) 1.21
Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs. J Physiol (2004) 1.19
Addiction and arousal: the hypocretin connection. Physiol Behav (2007) 1.19
GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep. Eur J Neurosci (2010) 1.17
Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice. Eur J Neurosci (2007) 1.17
Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep (2009) 1.16
REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep (2007) 1.16
Sleep neurobiology from a clinical perspective. Sleep (2011) 1.14
The histaminergic network in the brain: basic organization and role in disease. Nat Rev Neurosci (2013) 1.14
New developments in sleep research: molecular genetics, gene expression, and systems neurobiology. J Neurosci (2008) 1.14
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. Br J Pharmacol (2014) 1.14
Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice. Sleep (2011) 1.13
Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep (2009) 1.13
DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep (2014) 1.13
CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome. Sleep (2009) 1.13
Eating disorder and metabolism in narcoleptic patients. Sleep (2007) 1.11
IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One (2009) 1.11
Orexin, stress, and anxiety/panic states. Prog Brain Res (2012) 1.11
Canine behavioral genetics: pointing out the phenotypes and herding up the genes. Am J Hum Genet (2008) 1.10
Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level. J Neurosci (2011) 1.10
The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats. Neuroscience (2007) 1.09
Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neurosci (2013) 1.09
Understanding hereditary diseases using the dog and human as companion model systems. Mamm Genome (2007) 1.09
Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci (2012) 1.07
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol (2009) 1.07
Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell. Biol Psychiatry (2008) 1.07
GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol (2006) 1.06
Abnormal sleep-cardiovascular system interaction in narcolepsy with cataplexy: effects of hypocretin deficiency in humans. Sleep (2012) 1.06
Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice. Exp Neurol (2009) 1.05
Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci (2011) 1.05
Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep (2014) 1.04
The autoimmune basis of narcolepsy. Curr Opin Neurobiol (2013) 1.03
Hypocretin/orexin in arousal and stress. Brain Res (2009) 1.03
Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep (2014) 1.02
Hypersomnia and depressive symptoms: methodological and clinical aspects. BMC Med (2013) 1.01
Neurophysiology of sleep and wakefulness: basic science and clinical implications. Curr Neuropharmacol (2008) 1.01
Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci (2013) 1.01
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. Eur J Neurosci (2008) 1.01
Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. J Neurophysiol (2008) 1.01
Narcolepsy and excessive daytime sleepiness. BMJ (2004) 1.00
Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Sleep (2014) 1.00
Narcolepsy: a review. Neuropsychiatr Dis Treat (2011) 1.00
Optogenetic deconstruction of sleep-wake circuitry in the brain. Front Mol Neurosci (2010) 1.00
Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science (1998) 13.64
The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA (1989) 12.07
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature (1980) 10.19
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99
Hypocretin (orexin) deficiency in human narcolepsy. Lancet (2000) 7.92
Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell (2000) 7.48
Reduced number of hypocretin neurons in human narcolepsy. Neuron (2000) 6.94
Variations in resource utilization among medical specialties and systems of care. Results from the medical outcomes study. JAMA (1992) 6.88
Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80
Reverse transcriptase template switching: a SMART approach for full-length cDNA library construction. Biotechniques (2001) 5.92
Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat Genet (1999) 5.81
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev (1995) 5.53
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature (1979) 5.35
Genetic diversity and disease control in rice. Nature (2000) 5.34
Patient and visit characteristics related to physicians' participatory decision-making style. Results from the Medical Outcomes Study. Med Care (1995) 5.17
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet (1996) 5.15
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet (1997) 5.11
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
The validity and relative precision of MOS short- and long-form health status scales and Dartmouth COOP charts. Results from the Medical Outcomes Study. Med Care (1992) 4.58
Activation of BPV-1 replication in vitro by the transcription factor E2. Nature (1991) 4.51
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell (1977) 4.34
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J Cell Biol (1999) 4.20
Health-related quality of life in patients served by the Department of Veterans Affairs: results from the Veterans Health Study. Arch Intern Med (1998) 4.07
Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Arch Gen Psychiatry (1995) 3.92
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med (1992) 3.63
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology (2003) 3.62
Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol (1990) 3.57
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A (1995) 3.47
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol (1998) 3.44
Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain (2005) 3.37
Differences in the mix of patients among medical specialties and systems of care. Results from the medical outcomes study. JAMA (1992) 3.32
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood (1996) 3.14
Familial patterns of narcolepsy. Lancet (1989) 3.07
Evaluation of the Hexaplex assay for detection of respiratory viruses in children. J Clin Microbiol (2001) 2.94
Dopaminergic role in stimulant-induced wakefulness. J Neurosci (2001) 2.91
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes. Cell (1981) 2.85
Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet (1997) 2.85
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J (1996) 2.83
Making and reading microarrays. Nat Genet (1999) 2.81
Exon shuffling generates an immunoglobulin heavy chain gene. Proc Natl Acad Sci U S A (1980) 2.80
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci U S A (1995) 2.80
Detection of depressive disorder for patients receiving prepaid or fee-for-service care. Results from the Medical Outcomes Study. JAMA (1989) 2.79
The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol (1997) 2.71
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry (2007) 2.70
Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neurosci Lett (1989) 2.69
Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. Curr Biol (1999) 2.64
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet (1999) 2.62
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med (1999) 2.61
Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Science (2001) 2.58
In vivo analysis of plant promoters and transcription factors by agroinfiltration of tobacco leaves. Plant J (2000) 2.57
Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci (1998) 2.54
Sequence homology requirements for intermolecular recombination in mammalian cells. Proc Natl Acad Sci U S A (1986) 2.50
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49
Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol (2001) 2.47
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
Cytokinesis in eukaryotes: a mechanistic comparison. Curr Opin Cell Biol (1999) 2.36
Health status in VA patients: results from the Veterans Health Study. Am J Med Qual (1999) 2.35
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology (2005) 2.33
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature (1997) 2.31
Parasitisms of catfish and other farm-raised food fish. J Am Vet Med Assoc (1995) 2.29
Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A (1999) 2.29
A CLOCK polymorphism associated with human diurnal preference. Sleep (1998) 2.24
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. Mol Cell Biol (1985) 2.22
The retinoblastoma gene product regulates Sp1-mediated transcription. Mol Cell Biol (1992) 2.21
A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content. Theor Appl Genet (2006) 2.21
The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A (1995) 2.18
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J Biol Chem (1998) 2.17
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur J Neurosci (2001) 2.15
Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. J Cell Biol (2000) 2.15
Immunoglobulin gene rearrangement in immature B cells. Science (1980) 2.14