Published in J Cell Biol on November 01, 1992
Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol (1999) 2.94
Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol (1995) 2.83
Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction. J Cell Biol (1996) 2.05
The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochem J (1994) 1.87
Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor. J Virol (1998) 1.83
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1). J Cell Biol (1995) 1.67
The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. J Clin Invest (1997) 1.55
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J (2003) 1.53
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. PLoS One (2014) 1.42
Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1995) 1.40
Angiogenesis. Cold Spring Harb Perspect Biol (2011) 1.37
alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cells. Mol Biol Cell (1997) 1.33
Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro. J Cell Biol (1999) 1.33
Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS One (2013) 1.27
Cell and heparin binding in the distal long arm of laminin: identification of active and cryptic sites with recombinant and hybrid glycoprotein. J Cell Biol (1993) 1.15
Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans. Mol Biol Cell (1999) 1.13
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. Mol Biol Cell (2000) 1.12
Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators. Dev Dyn (2008) 1.10
Perlecan and tumor angiogenesis. J Histochem Cytochem (2003) 1.09
Perlecan controls neurogenesis in the developing telencephalon. BMC Dev Biol (2007) 1.08
Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy. Proc Natl Acad Sci U S A (1993) 1.06
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J Biol Chem (2011) 1.04
Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. J Lipid Res (2008) 0.99
Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res (2011) 0.98
A biomechanical role for perlecan in the pericellular matrix of articular cartilage. Matrix Biol (2012) 0.93
A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation. Matrix Biol (2007) 0.92
Differential expression and functional behaviour of the alpha v and beta 3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro. Ann Rheum Dis (1997) 0.89
Control of organization and function of muscle and tendon by thrombospondin-4. Matrix Biol (2014) 0.86
Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint. Histochem Cell Biol (2005) 0.86
Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity. Sensors (Basel) (2009) 0.83
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains. Free Radic Biol Med (2010) 0.82
Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix. Matrix Biol (2015) 0.79
Perlecan regulates Oct-1 gene expression in vascular smooth muscle cells. Mol Biol Cell (1997) 0.78
Extracellular matrix molecules facilitating vascular biointegration. J Funct Biomater (2012) 0.77
Perlecan: an important component of the cartilage pericellular matrix. J Musculoskelet Neuronal Interact (2002) 0.75
Blood-Vessel Mimicking Structures by Stereolithographic Fabrication of Small Porous Tubes Using Cytocompatible Polyacrylate Elastomers, Biofunctionalization and Endothelialization. J Funct Biomater (2016) 0.75
Biochemical and biophysical changes underlie the mechanisms of basement membrane disruptions in a mouse model of dystroglycanopathy. Matrix Biol (2013) 0.75
Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia. J Cereb Blood Flow Metab (2015) 0.75
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Integrins: a family of cell surface receptors. Cell (1987) 21.14
New perspectives in cell adhesion: RGD and integrins. Science (1987) 18.41
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 8.87
Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell (1990) 8.41
Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. J Biol Chem (1987) 4.87
Fibronectin: purification, immunochemical properties, and biological activities. Methods Enzymol (1982) 4.45
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell (1990) 3.46
The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Biol (1990) 3.07
Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol (1990) 2.69
The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J Biol Chem (1991) 2.23
Self-assembly of basement membrane collagen. Biochemistry (1984) 2.19
Laminin-nidogen complex. Extraction with chelating agents and structural characterization. Eur J Biochem (1987) 2.15
Immunocytochemistry of cell surface heparan sulfate proteoglycan in mouse tissues. A light and electron microscopic study. J Histochem Cytochem (1987) 2.07
The collagenous components of the subendothelium. Correlation of structure and function. Lab Invest (1980) 1.87
Determination of the number of endothelial cells in culture using an acid phosphatase assay. Anal Biochem (1986) 1.71
Isolation of two forms of basement membrane proteoglycans. J Biol Chem (1985) 1.55
Endothelial cell-matrix interactions: in vitro models of angiogenesis. J Histochem Cytochem (1986) 1.49
Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans. J Biol Chem (1987) 1.38
Terminal short arm domains of basement membrane laminin are critical for its self-assembly. J Cell Biol (1990) 1.35
Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. J Cell Biol (1990) 1.32
Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan. J Biol Chem (1988) 1.26
Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin. J Biol Chem (1991) 1.26
Characterization of the major heparan sulfate proteoglycan secreted by bovine aortic endothelial cells in culture. Homology to the large molecular weight molecule of basement membranes. J Biol Chem (1989) 1.22
Structure of low density heparan sulfate proteoglycan isolated from a mouse tumor basement membrane. J Mol Biol (1987) 1.19
Aortic endothelial cell migration. I. Matrix requirements and composition. Am J Pathol (1982) 1.16
Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. J Biol Chem (1991) 1.12
Basement membrane proteoglycan in various tissues: characterization using monoclonal antibodies to the Engelbreth-Holm-Swarm mouse tumor low density heparan sulfate proteoglycan. J Cell Biol (1988) 1.11
Multiple forms of heparan sulfate proteoglycans in the Engelbreth-Holm-Swarm mouse tumor. The occurrence of high density forms bearing both heparan sulfate and chondroitin sulfate side chains. J Biol Chem (1987) 1.09
Glomerular basement membrane proteoglycans are derived from a large precursor. J Cell Biol (1988) 1.04
Biosynthesis of stromal matrix proteoglycans and basement membrane components by human corneal fibroblasts. Invest Ophthalmol Vis Sci (1992) 1.03
Components of subendothelial aorta basement membrane. Immunohistochemical localization and role in cell attachment. Lab Invest (1983) 1.03
The core protein of the matrix-associated heparan sulfate proteoglycan binds to fibronectin. J Biol Chem (1990) 1.00
Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb. Proc Natl Acad Sci U S A (1986) 1.00
Self-assembly of a high molecular weight basement membrane heparan sulfate proteoglycan into dimers and oligomers. J Biol Chem (1987) 0.96
A new method for sequencing linear oligosaccharides on gels using charged, fluorescent conjugates. Carbohydr Res (1991) 0.91
Identification of a cell surface-binding protein for the core protein of the basement membrane proteoglycan. J Biol Chem (1989) 0.90
Identification of the precursor protein for the heparan sulfate proteoglycan of human colon carcinoma cells and its post-translational modifications. Arch Biochem Biophys (1989) 0.88
Characterization of heparan sulfate proteoglycan from calf lens capsule and proteoglycans synthesized by cultured lens epithelial cells. Comparison with other basement membrane proteoglycans. J Biol Chem (1991) 0.80
A Mr 80K hepatocyte surface protein(s) interacts with basement membrane components. Exp Cell Res (1990) 0.80
Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med (1993) 4.99
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92
Form and function: the laminin family of heterotrimers. Dev Dyn (2000) 4.38
Capillary endothelial cell cultures: phenotypic modulation by matrix components. J Cell Biol (1983) 3.60
Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. J Mol Biol (1981) 3.15
Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. J Cell Biol (1980) 2.42
Laminin polymerization induces a receptor-cytoskeleton network. J Cell Biol (1999) 2.36
Codistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney. an immunoferritin study of ultrathin frozen sections. J Cell Biol (1980) 2.30
Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc Natl Acad Sci U S A (1995) 2.22
Self-assembly of basement membrane collagen. Biochemistry (1984) 2.19
Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol (1997) 2.17
Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science (1998) 2.02
Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93
Collagen polymorphism in the lung. An immunochemical study of pulmonary fibrosis. Hum Pathol (1980) 1.89
The collagenous components of the subendothelium. Correlation of structure and function. Lab Invest (1980) 1.87
Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment. J Biol Chem (1982) 1.84
Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells. J Biol Chem (1998) 1.80
Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity. J Biol Chem (1985) 1.79
Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components. Lab Invest (1986) 1.78
The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci (1998) 1.70
Role of basal lamina in neoplastic disorganization of tissue architecture. Proc Natl Acad Sci U S A (1981) 1.70
Self-assembly of laminin isoforms. J Biol Chem (1997) 1.65
Laminin-binding protein 120 from brain is closely related to the dystrophin-associated glycoprotein, dystroglycan, and binds with high affinity to the major heparin binding domain of laminin. J Biol Chem (1993) 1.58
Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. J Cell Sci (1998) 1.57
A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution. Endocrinology (1986) 1.55
The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J Cell Biol (1994) 1.52
Developmental expression of perlecan during murine embryogenesis. Dev Dyn (1997) 1.52
Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. Am J Pathol (1986) 1.50
Endothelial cell-matrix interactions: in vitro models of angiogenesis. J Histochem Cytochem (1986) 1.49
Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Brain Res Dev Brain Res (2000) 1.48
Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ. J Histochem Cytochem (1998) 1.47
Human capillary endothelial cells from abdominal wall adipose tissue: isolation using an anti-pecam antibody. In Vitro Cell Dev Biol Anim (1995) 1.47
Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J Biol Chem (1999) 1.41
Binding of laminin to type IV collagen: a morphological study. J Cell Biol (1985) 1.38
Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis. J Clin Invest (1996) 1.38
Mechanisms of cytoskeletal regulation: modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix. J Cell Physiol (1986) 1.37
PECAM-1 (CD31) expression modulates bleeding time in vivo. Am J Pathol (2000) 1.36
Extracellular matrix-cell interactions: dynamic modulators of cell, tissue and organism structure and function. Lab Invest (1992) 1.36
Terminal short arm domains of basement membrane laminin are critical for its self-assembly. J Cell Biol (1990) 1.35
Mechanisms of cytoskeletal regulation. Modulation of aortic endothelial cell spectrin by the extracellular matrix. Am J Pathol (1984) 1.33
Influence of the angiotensin system on endothelial and smooth muscle cell migration. Am J Pathol (1990) 1.32
Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. J Cell Biol (1990) 1.32
A new method of iodinating collagens for use in radioimmunoassay. Anal Biochem (1979) 1.32
Transforming growth factor beta 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis. J Cell Physiol (1990) 1.31
Scar cancers of the lung: origin and significance. Hum Pathol (1984) 1.31
Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor. J Clin Invest (1992) 1.30
Repopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro. A novel system for type II pneumocyte culture. Exp Cell Res (1986) 1.30
Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels. J Biol Chem (1987) 1.30
Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci U S A (1996) 1.28
Regulation of neurite outgrowth by integrin activation. J Neurosci (2000) 1.26
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc Natl Acad Sci U S A (1996) 1.25
Models for the self-assembly of basement membrane. J Histochem Cytochem (1986) 1.25
Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF-beta 1 correlates with reciprocal effects on cell migration. J Cell Physiol (1992) 1.24
Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis. J Clin Invest (1994) 1.24
Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties. J Biol Chem (1997) 1.23
The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model. Am J Pathol (1987) 1.23
Platelet endothelial cell adhesion molecule, PECAM-1, modulates cell migration. J Cell Physiol (1992) 1.22
Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model. In Vitro Cell Dev Biol Anim (2000) 1.22
PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. J Cell Sci (1999) 1.22
Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci U S A (1994) 1.22
Migrating epidermis produces AB2 collagen and requires continual collagen synthesis for movement. Nature (1979) 1.22
Mechanisms of cytoskeletal regulation: functional and antigenic diversity in human erythrocyte and brain beta spectrin. J Cell Biochem (1986) 1.21
Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle. Am J Physiol Heart Circ Physiol (2000) 1.20
Structure of low density heparan sulfate proteoglycan isolated from a mouse tumor basement membrane. J Mol Biol (1987) 1.19
Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain. Cell (1997) 1.19
Distribution of a 69-kD laminin-binding protein in aortic and microvascular endothelial cells: modulation during cell attachment, spreading, and migration. J Cell Biol (1988) 1.19
Methods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes. Lab Invest (1983) 1.19
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem (2000) 1.18
Mapping of network-forming, heparin-binding, and alpha 1 beta 1 integrin-recognition sites within the alpha-chain short arm of laminin-1. J Biol Chem (1995) 1.18
Use of avidin-biotin complex in an ELISA system: a quantitative comparison with two other immunoperoxidase detection systems using keratin antisera. Lab Invest (1983) 1.18
Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circ Res (1989) 1.18
Differential proteolytic susceptibility of laminin alpha and beta subunits. Arch Biochem Biophys (1982) 1.16
Aortic endothelial cell migration. I. Matrix requirements and composition. Am J Pathol (1982) 1.16
Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain. Hum Mol Genet (1997) 1.15
Cell and heparin binding in the distal long arm of laminin: identification of active and cryptic sites with recombinant and hybrid glycoprotein. J Cell Biol (1993) 1.15
Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for angiogenesis. Trends Cardiovasc Med (1999) 1.14
Isolation and tissue localization of type AB2 collagen from normal lung parenchyma. Am J Pathol (1979) 1.14
Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J Neuroimmunol (2000) 1.13
Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol (1997) 1.13
Collagen types I, III, and V in human embryonic and fetal skin. Am J Anat (1986) 1.11
Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol (1994) 1.11
Endothelial cell-matrix interactions in hemostasis. Prog Hemost Thromb (1982) 1.10
Multiple mechanisms of dissociated epidermal cell spreading. J Cell Biol (1983) 1.09
Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. Am J Pathol (1999) 1.09
Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Brain Res Dev Brain Res (2001) 1.08
Labeling complex carbohydrates of animal cells with monosaccharides. Methods Enzymol (1978) 1.08
The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins. J Biol Chem (1997) 1.08
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance. Am J Pathol (1990) 1.07
Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus. Am J Pathol (1997) 1.07
Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J Biol Chem (2001) 1.07
Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines. Cancer Res (1994) 1.06
Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2. J Biol Chem (1995) 1.05
Immunolocalization of type IV collagen and laminin in nonbasement membrane structures of murine corneal stroma. A light and electron microscopic study. Lab Invest (1985) 1.05
PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. FASEB J (2001) 1.05
The laminin alpha2 expressed by dystrophic dy(2J) mice is defective in its ability to form polymers. Curr Biol (1999) 1.05
Endothelial cell-extracellular matrix interactions. Ann N Y Acad Sci (1985) 1.04
Reconstitution of structure and cell function in human skin grafts derived from cryopreserved allogeneic dermis and autologous cultured keratinocytes. J Invest Dermatol (1988) 1.03
An immunohistochemical study of nasopharyngeal neoplasms using keratin antibodies: epithelial versus nonepithelial neoplasms. Am J Surg Pathol (1982) 1.03
Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation. Am J Pathol (2001) 1.03
Equilibration of fucosyl glycoprotein pools in HeLa cells. Biochemistry (1977) 1.02