Published in J Biol Chem on April 25, 1992
Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol (1999) 2.94
The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. J Cell Biol (2000) 2.06
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics (2010) 1.97
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol (2015) 1.91
The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochem J (1994) 1.87
Developmental and pathogenic mechanisms of basement membrane assembly. Curr Pharm Des (2009) 1.80
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated? J Clin Invest (1997) 1.75
A single EGF-like motif of laminin is responsible for high affinity nidogen binding. EMBO J (1993) 1.62
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. Proc Natl Acad Sci U S A (1993) 1.62
Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest (1998) 1.46
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A (1995) 1.43
The extracellular matrix in epithelial biology: shared molecules and common themes in distant phyla. Dev Biol (1996) 1.40
Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan. J Cell Biol (1992) 1.37
Mutations in the unc-52 gene responsible for body wall muscle defects in adult Caenorhabditis elegans are located in alternatively spliced exons. Genetics (1995) 1.35
Smooth muscle cell expression of extracellular matrix genes after arterial injury. Am J Pathol (1994) 1.32
Structural characterization of the complete human perlecan gene and its promoter. Proc Natl Acad Sci U S A (1993) 1.14
Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans. Mol Biol Cell (1999) 1.13
Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I. J Bone Miner Res (2002) 1.09
Perlecan and tumor angiogenesis. J Histochem Cytochem (2003) 1.09
Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. Nephrol Dial Transplant (2009) 1.09
Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study. Histochem Cell Biol (2005) 1.08
Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein-2-based matrices. Tissue Eng (2006) 1.06
Degradation of endothelial cell matrix heparan sulfate proteoglycan by elastase and the myeloperoxidase-H2O2-chloride system. Am J Pathol (1993) 1.05
Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA. Mol Cell Biol (1997) 1.01
Perlecan domain I promotes fibroblast growth factor 2 delivery in collagen I fibril scaffolds. Tissue Eng (2005) 1.00
Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders. Matrix Biol (2013) 0.99
Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. Eur Spine J (2008) 0.99
The proteoglycan Trol controls the architecture of the extracellular matrix and balances proliferation and differentiation of blood progenitors in the Drosophila lymph gland. Dev Biol (2013) 0.97
Role of perlecan in skeletal development and diseases. Glycoconj J (2003) 0.96
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways. PLoS One (2012) 0.95
Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem (2012) 0.92
A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation. Matrix Biol (2007) 0.92
Endostatin binds to blood vessels in situ independent of heparan sulfate and does not compete for fibroblast growth factor-2 binding. Am J Pathol (1999) 0.92
Proteoglycan synthesis in haematopoietic cells: isolation and characterization of heparan sulphate proteoglycans expressed by the bone-marrow stromal cell line MS-5. Biochem J (1997) 0.90
A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor. Biochem J (2001) 0.89
Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint. Histochem Cell Biol (2005) 0.86
Endorepellin evokes autophagy in endothelial cells. J Biol Chem (2014) 0.86
The glomerular basement membrane as a model system to study the bioactivity of heparan sulfate glycosaminoglycans. Microsc Microanal (2012) 0.86
Contribution of proteoglycans towards the integrated functions of renal glomerular capillaries: a historical perspective. Am J Pathol (2007) 0.85
Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's disease. Biomed Res Int (2014) 0.84
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains. Free Radic Biol Med (2010) 0.82
Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev (2015) 0.82
Perlecan immunolocalizes to perichondrial vessels and canals in human fetal cartilaginous primordia in early vascular and matrix remodeling events associated with diarthrodial joint development. J Histochem Cytochem (2004) 0.82
Similarity of recombinant human perlecan domain 1 by alternative expression systems bioactive heterogenous recombinant human perlecan D1. BMC Biotechnol (2010) 0.81
Soluble perlecan domain I enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells. BMC Biochem (2010) 0.81
Transcriptional activation by NFκB increases perlecan/HSPG2 expression in the desmoplastic prostate tumor microenvironment. J Cell Biochem (2014) 0.80
Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis. G3 (Bethesda) (2014) 0.78
Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis. PLoS One (2015) 0.78
Endorepellin-evoked Autophagy Contributes to Angiostasis. J Biol Chem (2016) 0.78
Binding of perlecan to transthyretin in vitro. Biochem J (1997) 0.78
Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients. Oncotarget (2016) 0.77
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect Tissue Res (2015) 0.77
Neonatal exposure to high doses of 17β-estradiol results in inhibition of heparanase-1 expression in the adult prostate. Histochem Cell Biol (2011) 0.77
Altered Proteoglycan Gene Expression in Human Biliary Cirrhosis. Pathol Oncol Res (1997) 0.77
A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol (2016) 0.76
Human Amnion Membrane: Potential Applications in Oral and Periodontal Field. J Int Soc Prev Community Dent (2017) 0.75
Analogs of LDL Receptor Ligand Motifs in Dengue Envelope and Capsid Proteins as Potential Codes for Cell Entry. J Viruses (2016) 0.75
Vascular growth factor binding kinetics to the endothelial cell basement membrane, with a kinetics-based correction for substrate binding. Cytotechnology (2009) 0.75
Extracellular Matrix, a Hard Player in Angiogenesis. Int J Mol Sci (2016) 0.75
Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol (1997) 6.42
Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med (2004) 4.16
Generic modelling of cooperative growth patterns in bacterial colonies. Nature (1994) 3.65
Pharyngoscopic views. Anesth Analg (1998) 3.49
Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage (2005) 3.47
Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation (1998) 3.43
The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflugers Arch (1979) 3.34
Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol (1998) 3.27
The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem (1996) 2.88
Exercise myocardial perfusion SPECT in patients without known coronary artery disease: incremental prognostic value and use in risk stratification. Circulation (1996) 2.86
Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage (2000) 2.77
EPIDURAL SPINAL INFECTIONS. Ann Surg (1938) 2.66
A tropomyosin-like protein from human platelets. J Mol Biol (1972) 2.65
Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology (1997) 2.54
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev (1994) 2.51
Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol (2001) 2.37
SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae. Genes Dev (1994) 2.37
Prostaglandin E inhibits the production of human interleukin 2. J Exp Med (1982) 2.34
The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Osteoarthritis Cartilage (2007) 2.26
The effects of potassium and temperature on the pace-maker current, iK2, in Purkinje fibres. J Physiol (1976) 2.20
Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem (1990) 2.16
Cooperative organization of bacterial colonies: from genotype to morphotype. Annu Rev Microbiol (1998) 2.12
Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res (2002) 2.08
Twenty-four hour observations on the metabolism of normal and starving subjects. J Physiol (1924) 1.97
ABDOMINAL PUNCTURE IN THE DIAGNOSIS OF ACUTE INTRAPERITONEAL DISEASE. Ann Surg (1926) 1.95
Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development (1994) 1.91
Model structure of decorin and implications for collagen fibrillogenesis. J Biol Chem (1996) 1.88
The Coventry Award. Polymerase chain reaction detection of bacterial infection in total knee arthroplasty. Clin Orthop Relat Res (1996) 1.83
Fibroblast growth factor-2. Int J Biochem Cell Biol (2000) 1.80
Large animal model of left ventricular aneurysm. Ann Thorac Surg (1989) 1.77
Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation (1999) 1.76
Case study: deterioration, autism, and recovery in two siblings. J Am Acad Child Adolesc Psychiatry (1995) 1.76
An analysis of the actions of low concentrations of ouabain on membrane currents in Purkinje fibres. J Physiol (1976) 1.71
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. J Clin Invest (1998) 1.70
Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases. J Biol Chem (1996) 1.67
Voltage clamp and tracer flux data: effects of a restricted extra-cellular space. Q Rev Biophys (1979) 1.67
Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol (2006) 1.66
Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol (1995) 1.64
Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med (2001) 1.60
Actin-linked regulation of the human platelet contractile system. FEBS Lett (1973) 1.57
Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo. J Biol Chem (2000) 1.55
The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. J Clin Invest (1997) 1.55
Clinical significance of endometrial fluid collections in asymptomatic postmenopausal women. J Ultrasound Med (1996) 1.53
Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures. Differentiation (1999) 1.52
Developmental expression of perlecan during murine embryogenesis. Dev Dyn (1997) 1.52
Incremental prognostic value of exercise thallium-201 myocardial single-photon emission computed tomography late after coronary artery bypass surgery. J Am Coll Cardiol (1995) 1.51
The "brown bowel syndrome" associated with jejunal carcinoma. Am J Gastroenterol (1993) 1.51
Sonographic detection of a foreign body in the urethra and urinary bladder. Urol Int (2000) 1.50
Complex bacterial patterns. Nature (1995) 1.50
Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer. Hum Reprod (1994) 1.49
Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. J Natl Cancer Inst (1997) 1.47
Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest (1998) 1.46
Resistance to Lyme disease in decorin-deficient mice. J Clin Invest (2001) 1.46
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest (1997) 1.44
Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int (1992) 1.44
Epidemiology and clinical consequences of drug-resistant tuberculosis in a Guatemalan hospital. Chest (1998) 1.43
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A (1995) 1.43
Biosynthesis of heparan sulfate proteoglycan by human colon carcinoma cells and its localization at the cell surface. J Cell Biol (1984) 1.42
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene (2001) 1.42
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage. Matrix (1993) 1.42
Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-beta 1. Differentiation (1995) 1.41
An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells. J Biol Chem (2000) 1.41
Decorin binds near the C terminus of type I collagen. J Biol Chem (2000) 1.40
Long-term transvaginal ultrasonographic endometrial follow-up in postmenopausal breast cancer patients with tamoxifen treatment. Gynecol Oncol (1999) 1.40
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proc Natl Acad Sci U S A (1998) 1.38
Hyperacute rejection in human-kidney allografts-shwartzman or arthus reaction? N Engl J Med (1969) 1.37
Cellular basis for the T wave of the electrocardiogram. Nature (1976) 1.37
The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem (1994) 1.36
Effects of [Ca2+] and [Mg2+] on the decay of miniature endplate currents. Nature (1978) 1.36
Ultrastructure of clots during isometric contraction. J Cell Biol (1982) 1.35
Thrombosthenin M. Purification and interaction with thrombin. Eur J Biochem (1969) 1.34
A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity. Oncogene (2006) 1.34
The voltage clamp of multicellular preparations. Prog Biophys Mol Biol (1977) 1.33
Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem (1999) 1.33
Membrane surface potential changes may alter drug interactions: an example, acetylcholine and curare. Science (1979) 1.32
Proteoglycans: structure, function, and role in neoplasia. Lab Invest (1985) 1.32
Self-organization in systems of self-propelled particles. Phys Rev E Stat Nonlin Soft Matter Phys (2000) 1.31
Plesiomonas: biology of the organism and diseases in children. Pediatr Infect Dis (1984) 1.31
Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem (2001) 1.29
Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. J Histochem Cytochem (1994) 1.29
Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function. Differentiation (1999) 1.27
Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells. Matrix Biol (1999) 1.26
Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A (2000) 1.25
The stochastic properties of spontaneous quantal release of transmitter at the frog neuromuscular junction. J Physiol (1974) 1.25
The intervals between miniature end-plate potentials in the frog are unlikely to be independently or exponentially distributed. J Physiol (1974) 1.24
Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ (2002) 1.23
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. Oncogene (2001) 1.22
Comparative prognostic value of automatic quantitative analysis versus semiquantitative visual analysis of exercise myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol (1998) 1.21
The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcif Tissue Int (1992) 1.21
Kinetics and absolute bioavailability of atenolol. Clin Pharmacol Ther (1979) 1.21
Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels. J Biol Chem (1990) 1.20
Mesenchymal progenitor cells derived from traumatized human muscle. J Tissue Eng Regen Med (2009) 1.20
International health training. The Tulane experience. Infect Dis Clin North Am (1995) 1.19
Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage (2007) 1.19
The interactions of protons, calcium and potassium ions on cardiac Purkinje fibres. J Physiol (1978) 1.19
HLA-D typing in multiple sclerosis: Israelis tested with European homozygous typing cells. Tissue Antigens (1982) 1.19
Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1994) 1.19
K+ fluctuations in the extracellular spaces of cardiac muscle. Evidence from the voltage clamp and extracellular K+ - selective microelectrodes. Circ Res (1982) 1.16
Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue. Lab Invest (1995) 1.16